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Your Environment. Your Health.

Program Publications: Colorado School of Mines: Investigating Biogeochemical Controls on Metal Mixture Toxicity Using Stable Isotopes and Gene Expressions

Superfund Research Program

Investigating Biogeochemical Controls on Metal Mixture Toxicity Using Stable Isotopes and Gene Expressions

Project Leader: James F. Ranville
Grant Number: R01ES024358
Funding Period: 2014-2020



  • Iwasaki Y, Cadmus P, Ranville JF, Clements WH. 2022. Stream mesocosm experiments show no protective effects of calcium on copper toxicity to macroinvertebrates. Environ Toxicol Chem 41(5):1304-1310. doi:10.1002/etc.5308 PMID:35156224
  • Kotalik CJ, Meyer JS, Cadmus P, Ranville JF, Clements WH. 2022. Integrated assessment of chemical and biological recovery after diversion and treatment of acid mine drainage in a rocky mountain stream. Environ Toxicol Chem doi:10.1002/etc.5515 PMID:36345954




  • Meyer JS, Traudt EM, Ranville JF. 2017. Is the factor-of-2 rule broadly applicable for evaluating the prediction accuracy of metal-toxicity models?. Bull Environ Contam Toxicol 100(1):64-68. doi:10.1007/s00128-017-2258-4 PMID:29270647
  • Traudt EM, Ranville JF, Meyer JS. 2017. Effect of age on acute toxicity of cadmium, copper, nickel, and zinc in individual-metal exposures to Daphnia magna neonates. Environ Toxicol Chem 36:113-119. doi:10.1002/etc.3507 PMID:27225713


  • Cadmus P, Clements WH, Williamson JL, Ranville JF, Meyer JS, Gutierrez Gines MJ. 2016. The use and field and mesocosm experiments to quantify effects of physical and chemical stressors in mining-contaminated streams. Environ Sci Technol 50(14):7825–7833. doi:10.1021/acs.est.6b01911 PMID:27362637
  • Traudt EM, Ranville JF, Smith S, Meyer JS. 2016. A test of the additivity of acute toxicity of binary-metal mixtures of ni with Cd, Cu, and Zn to Daphnia magna, using the inflection point of the concentration-response curves. Environ Toxicol Chem 35:1843-1851. doi:10.1002/etc.3342 PMID:26681657
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