Superfund Research Program
Molecular Pathology Core
Project Leader: Robbert Creton
Grant Number: P42ES013660
Funding Period: 2005-2021
Project-Specific Links
Patents
Final Progress Reports
PublicationsFinal Progress Reports
Studies and Results
The Molecular Pathology Core (MPC) provides researchers in the SRP with equipment and technical expertise necessary for the evaluation of morphological and molecular changes in cells, tissues, and organs following complex exposures to environmental contaminants. The MPC provided support in fixation, dehydration, embedding, and sectioning of paraffin-embedded and frozen samples; vibratome sectioning of soft tissue without freezing or paraffin embedding; ultrathin sectioning of plastic-embedded samples for electron microscopy, histological staining, immunolabeling; and assistance in scanning electron microscopy, transmission electron microscopy, and confocal laser scanning microscopy. Personnel in the MPC contributed directly to SRP research projects led by Kim Boekelheide, Surendra Sharma, Agnes Kane, and Robert Hurt, as well as other SRP-related research projects (Table 1).
Table 1. Publications supported by the Molecular Pathology Core
| 2014 | ref | MPC Role | SRP/Related | T |
|---|---|---|---|---|
| Catlin et al. (2014a). Toxicol Pathol. 42(8):1221-1228. | [1] | Contribution | SRP Project | T |
| Catlin et al. (2014b). Toxicol Pathol. 42(8):1229-1237. | [2] | Contribution | SRP Project | T |
| Clift et al. (2014). Zebrafish. 11(5):455-461. | [3] | Author | SRP-related | - |
| Grive et al. (2014). Dev Biol. 392:42-51. | [4] | Contribution | - | T |
| Lindgren et al. (2014). Nature 506:484-488. | [5] | Acknowledgement | - | T |
| Richendrfer et al. (2014). Nova Science Publishers, book chapter. | [6] | Author | SRP-related | - |
| Spade et al. (2014). Toxicol Sci 138;148-160 | [7] | Acknowledgement | SRP Project | - |
| Spade et al. (2014). Dev Reprod Toxicol. 101:410-422. | [8] | Contribution | SRP Project | - |
MPC = Molecular Pathology Core. T = Training (At least one of the co-authors received training in the MPC). Publications are linked to the MPC in NIH progress reports only if MPC personnel co-author an SRP project publication.
Significance
The MPC provided researchers in the SRP with equipment and technical expertise necessary for the evaluation of morphological and molecular changes in cells, tissues, and organs following complex exposures. A better understanding of these morphological and molecular changes is important for the detection, diagnosis, and prevention of disease caused by complex exposures to environmental contaminants.