Superfund Research Program
Molecular Pathology Core
Project Leader: Robbert Creton
Grant Number: P42ES013660
Funding Period: 2005-2021
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The Molecular Pathology Core is a research support core providing researchers in the Brown SRP with equipment, technical expertise, and training necessary for the evaluation of morphological and molecular changes in cells, tissues, and organs following exposures to environmental contaminants. This successful Core completed its work during the first quarter of 2020 and has been formally discontinued. The Brown SRP team has concluded that its future needs for these services can be more rationally provided through a fee-for-service arrangement, which is already in place for other (non-SRP) campus users. When the Core was active in 2019, it contributed to experimental research in the Nanomaterial Design for Environmental Health and Safety Project on the development of graphene nanochannel membranes for water filtration. These membranes are formed by imbedding wrinkled graphene films in epoxy and preparing thin sections that reveal the tops and bottoms of the wrinkle ridges, which become arrays of nanochannels running across the membrane. This fabrication process relies on imbedding and microtoming techniques developed for biological sample preparation, and Core staff member Paul Weston made an essential contribution to these experiments. The article describing this work was released for publication just recently in Nature Communications (Liu 2021).