Superfund Research Program

Molecular Pathology Core

Project Leader: Robbert Creton
Grant Number: P42ES013660
Funding Period: 2005-2021

Project-Specific Links

Publications

2021

• Liu M, Weston P, Hurt RH. 2021. Controlling nanochannel orientation and dimensions in graphene-based nanofluidic membranes. Nat Commun 12:507. doi:10.1038/s41467-020-20837-2 PMID:33479231 PMCID:PMC7820404

2019

• Bianchi E, Boekelheide K, Sigman M, Braun JM, Eliot M, Hall SJ, Dere E, Hwang K. 2019. Spermatozoal large RNA content is associated with semen characteristics, sociodemographic and lifestyle factors. PLoS One 14(5):doi:10.1371/journal.pone.0216584 PMID:31120914 PMCID:PMC6532849
• Kabadi PK, Rodd AL, Simmons AE, Messier N, Hurt RH, Kane AB. 2019. A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations. Part Fibre Toxicol 16(1):15. doi:10.1186/s12989-019-0298-0 PMID:30943996 PMCID:PMC6448215
• Spade DJ, Dere E, Hall SJ, Schorl C, Freiman RN, Boekelheide K. 2019. All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate. Toxicol Sci 167:546-558. doi:10.1093/toxsci/kfy260 PMID:30329139 PMCID:PMC6358251
• Spade DJ, Hall SJ, Wortzel J, Reyes G, Boekelheide K. 2019. All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity. Toxicol Sci 168(1):149-159. doi:10.1093/toxsci/kfy283 PMID:30476341 PMCID:PMC6390659
• Stermer A, Reyes G, Hall SJ, Boekelheide K. 2019. Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether. Toxicol Sci 169(2):399-408. doi:10.1093/toxsci/kfz041 PMID:30768127 PMCID:PMC6934889

2017

• Bianchi E, Boekelheide K, Sigman M, Hall SJ, Hwang K. 2017. Ghrelin modulates testicular damage in a cryptorchid mouse model. PLoS One 12:e0177995. doi:10.1371/journal.pone.0177995 PMID:28542403 PMCID:PMC5436858
• Brayboy LM, Oulhen N, Long S, Voigt N, Raker C, Wessel GM. 2017. Multidrug resistance transporter-1 and breast cancer resistance protein protect against ovarian toxicity, and are essential in ovarian physiology. Reprod Toxicol 69:121-131. doi:10.1016/j.reprotox.2017.02.002 PMID:28216407 PMCID:PMC5568689
• Dai MS, Hall SJ, Vantangoli Policelli M, Boekelheide K, Spade DJ. 2017. Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Andrology 5:1141-1152. doi:10.1111/andr.12409 PMID:28834365 PMCID:PMC5673550
• Munarin F, Kaiser NJ, Yun KT, Choi B, Coulombe KL. 2017. Laser-etched designs for molding hydrogel-based engineered tissues. Tissue Eng Part C Methods 23:311-321. doi:10.1089/ten.TEC.2017.0068 PMID:28457187 PMCID:PMC5444510
• Najrana T, Ramos LM, Eid RA, Sanchez-Esteban J. 2017. Oligohydramnios compromises lung cells size and interferes with epithelial-endothelial development. Pediatr Pulmonol 52:746-756. doi:10.1002/ppul.23662 PMID:28152278
• Rodd AL, Messier N, Vaslet CA, Kane AB. 2017. A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144. doi:10.1016/j.aquatox.2017.02.018 PMID:28282620 PMCID:PMC5436724
• Rupert CE, Coulombe KL. 2017. IGF1 and NRG1 enhance proliferation, metabolic maturity, and the force-frequency response in hESC-derived engineered cardiac tissues. Stem Cells Int 2017:7648409. doi:10.1155/2017/7648409 PMID:28951744 PMCID:PMC5603111

2016

• Gonzalez ST, Remick D, Creton R, Colwill RM. 2016. Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish. Neurotoxicology 53:93-101. doi:10.1016/j.neuro.2015.12.018 PMID:26748073 PMCID:PMC4808333
• Lovato AK, Creton R, Colwill RM. 2016. Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on larval zebrafish behavior. Neurotoxicol Teratol 53:1-10. doi:10.1016/j.ntt.2015.11.002 PMID:26561944 PMCID:PMC4703504
• Zhu WP, von dem Bussche A, Yi X, Qiu Y, Wang Z, Weston P, Hurt RH, Kane AB, Gao H. 2016. Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles. Proc Natl Acad Sci U S A 113(44):12374-12379. doi:10.1073/pnas.1605030113 PMID:27791073 PMCID:PMC5098676

2015

• Clift DE, Thorn RJ, Passarelli EA, Kapoor M, LoPiccolo MK, Richendrfer HA, Colwill RM, Creton R. 2015. Effects of embryonic cyclosporine exposures on brain development and behavior. Behav Brain Res 282:117-124. doi:10.1016/j.bbr.2015.01.006 PMID:25591474 PMCID:PMC4323675
• Kabadi PK, Vantangoli MM, Rodd AL, Kane AB, Boekelheide K, Leary E, Madnick SJ, Morgan J. 2015. Into the depths: Techniques for in vitro three-dimensional microtissue visualization. Biotechniques 59(5):279-286. doi:10.2144/000114353 PMID:26554505 PMCID:PMC4804457
• Richendrfer HA, Creton R. 2015. Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity. Neurotoxicology 49:50-58. doi:10.1016/j.neuro.2015.05.002 PMID:25983063 PMCID:PMC4523399
• Vantangoli MM, Madnick SJ, Huse SM, Weston P, Boekelheide K. 2015. MCF-7 human breast cancer cells form differentiated microtissues in scaffold-free hydrogels. PLoS One 10(8):e0135426. doi:10.1371/journal.pone.0135426 PMID:26267486 PMCID:PMC4534042

2012

• Saffarini CM, Heger NE, Yamasaki H, Liu T, Hall SJ, Boekelheide K. 2012. Induction and persistence of abnormal testicular germ cells following gestational exposure to di-(n-butyl) phthalate in p53-null mice. J Androl 33(3):505-513. doi:10.2164/jandrol.111.013706 PMID:21868749 PMCID:PMC3607946
• Sanchez V, Jachak A, Hurt RH, Kane AB. 2012. Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol 25(1):15-34. doi:10.1021/tx200339h PMID:21954945 PMCID:PMC3259226

2011

• Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB. 2011. Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124(1):138-148. doi:10.1093/toxsci/kfr206 PMID:21828359 PMCID:PMC3196652 (Completed with ARRA Funds)
• Sanchez V, Weston P, Yan A, Hurt RH, Kane AB. 2011. A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials. Part Fibre Toxicol 8:17. doi:10.1186/1743-8977-8-17 PMID:21592387 PMCID:PMC3120675 (Completed with ARRA Funds)

2009

• Paul E, Cronan R, Weston P, Boekelheide K, Sedivy JM, Lee S, Wiest DL, Resnick MB, Klysik J. 2009. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome 20(2):92-108. doi:10.1007/s00335-008-9168-z PMID:19145458 PMCID:PMC2667228

2008

• Klysik J, Theroux SJ, Sedivy JM, Moffit JS, Boekelheide K. 2008. Signaling crossroads: The function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal 20:1-9. PMID:17706925