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Your Environment. Your Health.

University of Washington: Dataset Details, ID=GSE47039

Superfund Research Program

Effects-Related Biomarkers of Environmental Neurotoxic Exposures

Center Director: Evan P. Gallagher
Grant Number: P42ES004696
Funding Period: 1987-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Title: Transcriptional impact of organophosphate and metal mixtures on olfaction: copper dominates the chlorpyrifos-induced response in adult zebrafish.

Accession Number: GSE47039

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE47039

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Danio rerio

Summary: Chemical exposures in fish have been linked to loss of olfaction leading to an inability to detect predators and prey and decreased survival. However, the mechanisms underlying olfactory neurotoxicity are not well characterized, especially in environmental exposures which involve chemical mixtures. We used zebrafish to characterize olfactory transcriptional responses by two model olfactory inhibitors, the pesticide chlorpyrifos (CPF) and mixtures of CPF with the neurotoxic metal copper (Cu).

Publication(s) associated with this dataset:
  • Tilton F, Tilton SC, Bammler TK, Beyer RP, Stapleton PL, Scholz N, Gallagher EP. 2011. Transcriptional impact of organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish. Aquat Toxicol 102(3-4):205-215. doi:10.1016/j.aquatox.2011.01.012 PMID:21356183 PMCID:PMC3991301
  • Tilton F, Tilton SC, Bammler TK, Beyer RP, Farin FM, Stapleton PL, Gallagher EP. 2008. Transcriptional biomarkers and mechanisms of copper-induced olfactory injury in zebrafish. Environ Sci Technol 42(24):9404-11. doi:10.1021/es801636v PMID:19174923
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