Superfund Research Program
Effects-Related Biomarkers of Environmental Neurotoxic Exposures
Center Director: Evan P. Gallagher
Grant Number: P42ES004696
Funding Period: 1987-2022
News Items List
Changes in gut, liver may contribute to Alzheimers disease susceptibility
Paper of the Month - March 2022
NIEHS-funded researchers determined how changes in the gut and liver may contribute to cadmium-induced Alzheimers disease (AD). They previously showed that male mice with a genetic variant called apolipoprotein E4 (ApoE4), a known risk factor for AD, were most susceptible to the disease following cadmium exposure. Here, they shed light on how cadmium and ApoE4 alter the gut and liver in ways that may promote AD.
Scientists design risk communication strategies to improve health
Environmental Factor - November 2021
At NIEHS Superfund Research Program event, hundreds learned about tailoring public messages related to environmental risk.
UW SRP Researchers Work with Agency Partners to Communicate Risk
SRP News Page - August 2021
Researchers from the NIEHS-funded University of Washington (UW) Superfund Research Program (SRP) Center found new evidence that environmental contamination from a former smelter in Ruston, Washington may pose a threat to human health in surrounding areas. Before publishing the results, the team reached out to coordinate risk communication strategies with agency partners and share the findings with potentially affected communities.
SRP Grantees Share Innovative Science at Microbiome Conference
SRP News Page - April 2021
In an NIEHS virtual symposium, held February 23-24, NIEHS Superfund Research Program (SRP) grantees were well represented within the broader NIEHS community, sharing their efforts to understand the relationship between environmental exposures, the microbiome, and human health.
Ongoing Duwamish River recovery inspires video series, book
Environmental Factor - August 2020
A century ago, engineers and city planners straightened and deepened the Duwamish River to create an industrial center for the young city of Seattle. As the city grew, the waterway became contaminated with sewage, toxic chemicals, and storm water runoff. In 2001, the river was listed as a Superfund site. Now, the University of Washington (UW) Superfund Research Program (SRP) is promoting a new video series and a book, released July 11, to educate people about this important waterway.
K.C. Donnelly Externships awarded to outstanding Superfund trainees
Environmental Factor - August 2020
Eleven outstanding trainees in the NIEHS Superfund Research Program (SRP) have won K.C. Donnelly Externship Award Supplements. The annual awards allow trainees to work side-by-side with experts at an outside institution to learn new methods and techniques to enrich their research.
Videos Offer Advice for Safe Fishing Along Polluted River
SRP News Page - July 2020
A new nine-part, multilingual video series delivers critical fish consumption information to Seattle communities who fish the contaminated Duwamish River for food, recreation, and cultural reasons. The video series covers a range of topics, including an introduction to salmon fishing, how much salmon is safe to eat, and how to prepare and cook various salmon dishes. To meet the needs of the area s culturally diverse fishing community, they are available in Spanish, Vietnamese, and Khmer, the official language of Cambodia.
Cadmium Exposure Impairs Production of Neurons Responsible for Learning and Memory
Research Brief - January 2020
A new study funded by the Superfund Research Program (SRP) shows cadmium exposure can impair new neurons from forming and maturing in the hippocampus region of the brain. Led by Zhengui Xia, Ph.D., the researchers at the University of Washington (UW) SRP Center also found that cadmium can lead to the death of stem cells that produce these neurons. In people, learning and memory formation depends on the production of new neurons in this region of the brain.
River tour during SRP meeting spotlights local perspectives
Environmental Factor - January 2020
On the last day of the 2019 NIEHS Superfund Research Program (SRP) Annual Meeting, held Nov. 18-20 in Seattle, participants were offered a boat tour of the Duwamish River. Organized by meeting hosts from the University of Washington (UW) SRP Center, the tour spotlighted the history of the Lower Duwamish Waterway Superfund Site and the community groups that have worked to protect the river as a cultural resource.
SRP Researchers Reflect on Sharing Research Results at PEPH Network Meeting
SRP News Page - February 2019
Environmental health science professionals came together to discuss reporting back research results at the annual NIEHS Partnerships for Environmental Public Health (PEPH) meeting, held Dec 13-14. Among the participants, members of several Superfund Research Program (SRP)-funded Centers shared their experiences and tools focused on reporting research results back to study participants. According to an NIEHS story, the meeting reflected a critical need to ensure that individuals and communities that are part of a research study have access to their data and information on what it means for their health.
New houseplant enhances cleanup of air in homes
Paper of the Month - February 2019
Scientists previously funded by NIEHS developed a houseplant that can remove chloroform and benzene from the air around it. Benzene in the home can originate from outside air, fuel storage in attached garages, and tobacco smoke. Chloroform can be released into the air in small amounts from water during showering.
Why Shallow Lake Food Webs May Have More Arsenic
Research Brief - September 2018
Lake properties impact the amount of arsenic that transfers from sediments into the aquatic food web, according to a new SRP study. Researchers discovered high concentrations of arsenic in the water and plankton of well-mixed shallow lakes.
Platform Allows Rapid Analysis of Antioxidant Genes in Zebrafish
Research Brief - May 2017
A newly developed panel of zebrafish genes can be combined with a rapid testing platform to identify chemicals that induce oxidative stress, according to researchers at the University of Washington (UW) Superfund Research Program (SRP) Center. The method, optimized for use on larval zebrafish by UW SRP Center researchers, is cost-effective and can be performed more quickly and with less tissue than conventional methods.