Superfund Research Program
March 2022 NIEHS-funded researchers determined how changes in the gut and liver may contribute to cadmium-induced Alzheimers disease (AD). They previously showed that male mice with a genetic variant called apolipoprotein E4 (ApoE4), a known risk factor for AD, were most susceptible to the disease following cadmium exposure. Here, they shed light on how cadmium and ApoE4 alter the gut and liver in ways that may promote AD. [Full Text]