Superfund Research Program
Gene-Environment Interactions in Salmon Neurotoxicity
Project Leader: Evan P. Gallagher
Grant Number: P42ES004696
Funding Period: 2006-2009
Project-Specific Links
- Project Summary
Title: Transcriptional impact of organophosphate and metal mixtures on olfaction: copper dominates the chlorpyrifos-induced response in adult zebrafish.
Accession Number: GSE47039
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE47039
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Danio rerio
Summary: Chemical exposures in fish have been linked to loss of olfaction leading to an inability to detect predators and prey and decreased survival. However, the mechanisms underlying olfactory neurotoxicity are not well characterized, especially in environmental exposures which involve chemical mixtures. We used zebrafish to characterize olfactory transcriptional responses by two model olfactory inhibitors, the pesticide chlorpyrifos (CPF) and mixtures of CPF with the neurotoxic metal copper (Cu).
Publication(s) associated with this dataset:- Wang L, Bammler TK, Beyer RP, Gallagher EP. 2013. Copper-induced deregulation of microRNA expression in the zebrafish olfactory system. Environ Sci Technol 47(13):7466-7474. doi:10.1021/es400615q PMID:23745839 PMCID:PMC4750873
- Tilton F, Tilton SC, Bammler TK, Beyer RP, Stapleton PL, Scholz N, Gallagher EP. 2011. Transcriptional impact of organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish. Aquat Toxicol 102(3-4):205-215. doi:10.1016/j.aquatox.2011.01.012 PMID:21356183 PMCID:PMC3991301
- Tilton F, Tilton SC, Bammler TK, Beyer RP, Farin FM, Stapleton PL, Gallagher EP. 2008. Transcriptional biomarkers and mechanisms of copper-induced olfactory injury in zebrafish. Environ Sci Technol 42(24):9404-11. doi:10.1021/es801636v PMID:19174923