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Your Environment. Your Health.

Michigan State University: Dataset Details, ID=GSE89430

Superfund Research Program

Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands

Center Director: Norbert E. Kaminski
Grant Number: P42ES004911
Funding Period: 1989-2027
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Title: RNA-Seq Analysis of Dose-Dependent TCDD-Elicited Ileal Gene Expression in Male Mice

Accession Number: GSE89430

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89430

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Array expression profiling by high throughput sequencing

Organism(s): Mus musculus

Summary: Dose-dependent ileal gene expression was examined following repeated exposure (every 4 days for 28 days) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). These data were used to examine the effect of repeated TCDD exposure on gene expression in the intestinal epithelium of C57BL/6 male mice.

Publication(s) associated with this dataset:
  • Fader KA, Nault R, Kumagai K, Harkema JR, Zacharewski TR, Zhang C. 2017. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism. Sci Rep 7:5921. doi:10.1038/s41598-017-05656-8 PMID:28725001 PMCID:PMC5517430
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