Research Briefs: Michigan State University

Superfund Research Program

Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands

Center Director: Norbert E. Kaminski
Grant Number: P42ES004911
Funding Period: 1989-2027

Program Links

Research Briefs

• 337 - Dioxin Disrupts Liver Cells in Mice, Potential Link with Liver Disease -- Zacharewski, Nault
  Release Date: 01/11/2023

  An NIEHS Superfund Research Program (SRP)-funded study in mice reported that exposure to a type of dioxin can alter cells in the liver, their metabolic characteristics, and how they are organized within the liver. According to the researchers, these changes in cell behavior and organization play a role in the development of dioxin-induced liver diseases, such as fibrosis and fatty liver disease.

• 312 - Improved Sequencing Method Leads to Advancements in Toxicology Research -- Zacharewski
  Release Date: 12/02/2020

  NIEHS-funded Superfund Research Program (SRP) scientists are employing a new RNA sequencing method to assess mechanisms of toxicity on a finer and more accessible scale. Researchers in SRP grantee Tim Zacharewski's Lab at the Michigan State University (MSU) SRP Center conducted the study.

• 275 - Activated Carbon Reduces the Effects of TCDD on the Immune System and Gut Microbiome in a Mammalian Model -- Boyd, Hashsham
  Release Date: 11/01/2017

  Breakthroughs from the Michigan State University Superfund Research Program (MSU SRP) Center provide new evidence that activated carbon may be used to reduce health risks resulting from dioxin contamination.

• 188 - TCDD May Contribute to Immune System Instability -- Kaminski
  Release Date: 08/04/2010
  A new computational model shows how the environmental contaminant TCDD causes immune system mayhem by interfering with the activation of crucial B cells.

• 183 - Sequestration of Dioxin by Clays -- Boyd
  Release Date: 03/03/2010

  Although the organic matter in soil is often considered best for sequestering contaminants, new evidence shows that clay is as good--and perhaps better--at sequestering dioxins.

• 143 - Toxicological Assessment of Remediated Environmental Chemicals -- Trosko
  Release Date: 11/01/2006
  
  
• 88 - Investigating Tools to Improve Risk Assessment for PCB-Induced Immune Dysfunction -- Ganey
  Release Date: 04/03/2002
  
  
• 82 - Microbial Degradation of PCBs -- Tiedje
  Release Date: 10/03/2001
  
  
• 74 - In-situ Ozonation of PAHs - Feasibility, Pathways, and Byproduct Identification -- Masten
  Release Date: 02/07/2001
  
  
• 62 - Understanding the Effects of Polychlorinated Biphenyls on the Uterus -- Loch-Caruso
  Release Date: 01/05/2000
  
  
• 47 - Investigating the Mass Transfer and Persistence of Nonaqueous Phase Liquids in the Subsurface Environment -- Abriola
  Release Date: 06/02/1999