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Your Environment. Your Health.

Michigan State University: Dataset Details, ID=GSE80953

Superfund Research Program

Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands

Center Director: Norbert E. Kaminski
Grant Number: P42ES004911
Funding Period: 1989-2027
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Title: Temporal comparison of transcriptomic alterations in human, mouse and rat primary B lymphocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Accession Number: GSE80953

Link to Dataset:

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by high throughput sequencing

Organism(s): Homo sapiens, Mus musculus, Rattus norvegicus

Summary: RNA-Seq was used to analyze and compare temporal TCDD-induced gene expression changes in primary human, mouse and rat B cells. Most of the differentially expressed genes exibited species-specific expression. Cross-species comparison identified 28 orthologs commonly deregulated in all 3 species. The study provides new insight into mechanisms of TCDD-induced suppression of B cell effector function.

Publication(s) associated with this dataset:
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