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University of Arizona: Dataset Details, ID=GSE18009

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Superfund Research Program

Exposures, Health Impacts, and Risk for Mine Waste Contamination

Center Director: Xinxin Ding
Grant Number: P42ES004940
Funding Period: 1990-2025
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Title: Gene expression profiling in the fetal cardiac tissue after folate and low dose trichloroethylene exposure

Accession Number: GSE18009

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18009

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Mus musculus

Summary: To identify transcriptional targets altered in the embryonic heart after exposure to TCE, and possible protective effects of folate, we used DNA microarray technology to profile gene expression in embryonic mouse hearts with maternal TCE exposure and dietary changes in maternal folate. Results: Exposure to low doses of TCE (10ppb) caused extensive alterations in transcripts encoding proteins involved in transport, ion channel, transcription, differentiation, cytoskeleton, cell cycle and apoptosis. Exogenous folate did not offset the effects of TCE exposure on normal gene expression and both high and low levels of folate produced additional significant changes in gene expression. Conclusions: A mechanism where TCE induces a folate deficiency does not explain altered gene expression patterns in the embryonic mouse heart. The data further suggest that use of folate supplementation, in the presence of this toxin, may be detrimental and non-protective of the developing embryo.

Publication(s) associated with this dataset:
  • Caldwell P, Manziello A, Howard J, Palbykin B, Runyan RB, Selmin O. 2010. Gene expression profiling in the fetal cardiac tissue after folate and low dose trichloroethylene exposure. Birth Defects Res A Clin Mol Teratol 88(2):111-127. doi:10.1002/bdra.20631 PMID:19813261 PMCID:PMC4045246
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