Title: Toxicokinetics and toxicodynamics of tetrachloroethylene in males of 45 Collaborative Cross strains of mice

Accession Number: Rusyn7

Link to Dataset: https://phenome.jax.org/projects/Rusyn7

Repository: Mouse Phenome Database (MPD)

Data Type(s): Genotype/Phenotype

Experiment Type(s): Phenotype measurements

Organism(s): Mus musculus

Summary: Male mice from 45 strains of the Collaborative Cross were orally administered a single dose of tetrachloroethylene (percholorethylene, PERC) or vehicle and euthanized at various time points to generate population-level concentration-time profiles for PERC and its primary oxidative metabolite trichloroacetate (TCA) across multiple tissues. Toxicodynamic phenotyping included study of the expression of CYPs and dysregulation of hepatic lipid metabolism.

Publication(s) associated with this dataset:

• Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344