Superfund Research Program
Elucidating Risks: From Exposure and Mechanism to Outcome
Center Director: Rebecca C. Fry
Grant Number: P42ES005948
Funding Period: 1992-2018
Program Links
Title: Transcriptional profiling of HT-29 cells stimulated with pairwise combinations of TNF, EGF, and insulin
Accession Number: GSE69639
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE69639
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Homo sapiens
Summary: The objective of this study was to investigate the link between signaling-network activation and transcriptional regulation downstream of tumor necrosis factor (TNF), epidermal growth factor (EGF), and insulin. Microarrays were used to capture the transcriptional responses to TNF, EGF, and insulin at intermediate-to-late times after stimulation.
Publication(s) associated with this dataset:- Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA. 2016. TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Sci Signal 9(431):ra59. doi:10.1126/scisignal.aad3373 PMID:27273097 PMCID:PMC4914393