Superfund Research Program
Elucidating Risks: From Exposure and Mechanism to Outcome
Center Director: Rebecca C. Fry
Grant Number: P42ES005948
Funding Period: 1992-2018
Program Links
Title: Transcriptional profiling of inducible GATA6L-overexpressing HT-29 cells stimulated with TNF
Accession Number: GSE72079
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE72079
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Homo sapiens
Summary: The objective of this study was to investigate the role of GATA6L with or without TNF stimulation. Microarrays were used to capture the transcriptional response to GATA6L overexpression at intermediate times after TNF stimulation.
Publication(s) associated with this dataset:- Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA. 2016. TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Sci Signal 9(431):ra59. doi:10.1126/scisignal.aad3373 PMID:27273097 PMCID:PMC4914393