Superfund Research Program
Elucidating Mechanisms of Heavy Metal-Induced Toxicity and Disease
Project Leader: Rebecca C. Fry
Grant Number: P42ES005948
Funding Period: 2011-2018
Project-Specific Links
- Project Summary
Title: Formaldehyde and Epigenetic Alterations: MicroRNA Changes in the Nasal Epithelium of Nonhuman Primates
Accession Number: GSE34978
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34978
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by array
Organism(s): Homo sapiens
Summary: We set out to test the hypothesis that formaldehyde inhalation exposure significantly alters miRNA expression profiles within the nasal epithelium of nonhuman primates. Here, cynomolgus macaques were exposed to 0, 2, and 6 ppm formaldehyde for 6 hours/day across two consecutive days. RNA was extracted from the nasal maxilloturbinate region, a direct target of formaldehyde inhalation exposure. Genome-wide miRNA expression levels were assessed using microarrays.
Publication(s) associated with this dataset:- Rager JE, Moeller BC, Doyle-Eisele M, Kracko D, Swenberg JA, Fry RC. 2013. Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates. Environ Health Perspect 121(3):339-344. doi:10.1289/ehp.1205582 PMID:23322811 PMCID:PMC3621188