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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

University of Kentucky: Dataset Details, ID=E-MTAB-8798

Superfund Research Program

Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk

Project Leader: Kate Zaytseva
Co-Investigators: Bernhard Hennig, Hunter Nathaniel Moseley
Grant Number: P42ES007380
Funding Period: 1997-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Title: 16S rDNA sequencing data of Ldlr-/- mouse gut microbiomes

Accession Number: E-MTAB-8798

Link to Dataset: https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-8798

Repository: ArrayExpress

Data Type(s): Gene Expression

Experiment Type(s): DNA-seq

Organism(s): Mus musculus

Summary: We have previously demonstrated that the gut microbiota can play a role in the pathogenesis of conditions associated with exposure to environmental pollutants. It is well accepted that diets high in fermentable fibers such as inulin can beneficially modulate the gut microbiota and lessen the severity of pro-inflammatory diseases. Therefore, we aimed to test the hypothesis that hyperlipidemic mice fed a diet enriched with inulin would be protected from the pro-inflammatory toxic effects of PCB 126.

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