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Project Publications: University of Kentucky: Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk

Superfund Research Program

Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk

Project Leader: Kate Zaytseva
Co-Investigators: Bernhard Hennig, Hunter Nathaniel Moseley
Grant Number: P42ES007380
Funding Period: 1997-2025
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Publications

2024

  • Tessmann JW, Deng P, Durham J, Li C, Banerjee M, Wang Q, Goettl R, He D, Wang C, Lee EY, Evers BM, Hennig B, Zaytseva YY. 2024. Perfluorooctanesulfonic acid exposure leads to downregulation of 3-hydroxy-3-methylglutaryl-CoA synthase 2 expression and upregulation of markers associated with intestinal carcinogenesis in mouse intestinal tissues. Chemosphere 359:doi:10.1016/j.chemosphere.2024.142332 PMID:38754493 PMCID:11157449
  • Xiao X, Zhou Y, Li X, Jin J, Durham J, Ye Z, Wang Y, Hennig B, Deng P. 2024. (13)C-Stable isotope resolved metabolomics uncovers dynamic biochemical landscape of gut microbiome-host organ communications in mice. Microbiome 12(1):doi:10.1186/s40168-024-01808-x PMID:38750595 PMCID:11094917

2023

  • Durham J, Tessmann JW, Deng P, Hennig B, Zaytseva YY. 2023. The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis. Front Toxicol 5:1244457. doi:10.3389/ftox.2023.1244457 PMID:37662676 PMCID:PMC10469509
  • Wang Z, Zhou Y, Xiao X, Liu A, Wang S, Preston RJ, Zaytseva YY, He G, Xiao W, Hennig B, Deng P. 2023. Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions. Environ Pollut 339:122756. doi:10.1016/j.envpol.2023.122756 PMID:37844865

2022

  • Deng P, Durham J, Liu J, Zhang X, Wang C, Li D, Gwag T, Ma M, Hennig B. 2022. Metabolomic, lipidomic, transcriptomic, and metagenomic analyses in mice exposed to PFOS and fed soluble and insoluble dietary fibers. Environ Health Perspect 130(11):117003. doi:10.1289/EHP11360 PMID:36331819 PMCID:PMC9635512

2021

  • Deng P, Valentino, T, Flythe MD, Moseley HN, Leachman J, Morris AJ, Hennig B. 2021. Untargeted stable isotope probing of the gut microbiota metabolome using (13)C-labeled dietary fibers. J Proteome Res 20:doi:10.1021/acs.jproteome.1c00124 PMID:33830777

2020

  • Deng P, Hoffman JB, Petriello MC, Wang C, Li X, Kraemer MP, Morris AJ, Hennig B. 2020. Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice. J Lipid Res 61:45-53. doi:10.1194/jlr.RA119000346 PMID:31604806 PMCID:PMC6939596
  • Deng P, Wang C, Wahlang B, Sexton T, Morris AJ, Hennig B. 2020. Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice. Toxicol Appl Pharmacol 409:115301. doi:10.1016/j.taap.2020.115301 PMID:33096110 PMCID:PMC7725976
  • Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, Wang C, Zahtseva YY, Schwartz CE, Lee EY, Evers BM, Morris AJ, Liu S, She Q. 2020. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Nat Commun 11:doi:10.1038/s41467-020-17067-x PMID:32591507 PMCID:PMC7320137
  • Hennig B, Deng P. 2020. Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks. Food Front 1:13-14. doi:10.1002/fft2.6 PMID:33073239 PMCID:PMC7566652
  • Hoffman JB, Petriello MC, Morris AJ, Mottaleb MA, Sui Y, Zhou C, Deng P, Wang C, Hennig B. 2020. Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice. Environ Pollut 261:114183. doi:10.1016/j.envpol.2020.114183 PMID:32105967 PMCID:PMC7220843
  • Mottaleb MA, Petriello MC, Morris AJ. 2020. High-throughput UHPLC-MS/MS measurement of per- and poly-fluorinated alkyl substances in human serum. J Anal Toxicol 44(4):339-347. doi:10.1093/jat/bkz097 PMID:31776573 PMCID:PMC7299301

2019

2018

  • Gupta P, Thompson B, Wahlang B, Jordan CT, Hilt JZ, Hennig B, Dziubla TD. 2018. The environmental pollutant, polychlorinated biphenyls, and cardiovascular disease: a potential target for antioxidant nanotherapeutics. Drug Deliv Transl Res 8(3):740-759. doi:10.1007/s13346-017-0429-9 PMID:28975503 PMCID:PMC5882597
  • Hennig B, Petriello MC, Gamble MV, Surh Y, Kresty LA, Frank N, Rangkadilok N, Ruchirawat K, Suk WA. 2018. The role of nutrition in influencing mechanisms involved in environmentally mediated diseases. Rev Environ Health 33:87-97. doi:10.1515/reveh-2017-0038 PMID:29381475 PMCID:PMC5987536
  • Petriello MC, Brandon JA, Hoffman JB, Wang C, Tripathi H, Abdel-Latif A, Ye X, Li X, Yang L, Lee EY, Soman S, Barney J, Wahlang B, Hennig B, Morris AJ. 2018. Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor-deficient mice. Toxicol Sci 162(2):548-558. doi:10.1093/toxsci/kfx275 PMID:29216392 PMCID:PMC5888982
  • Petriello MC, Charnigo RJ, Sunkara M, Soman S, Pavuk M, Birnbaum LS, Morris AJ, Hennig B. 2018. Relationship between serum trimethylamine N-oxide and exposure to dioxin-like pollutants. Environ Res 162:211-218. doi:10.1016/j.envres.2018.01.007 PMID:29353125 PMCID:PMC5811317
  • Petriello MC, Hoffman JB, Vsevolozhskaya O, Morris AJ, Hennig B. 2018. Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis. Environ Pollut 242(A):1022-1032. doi:10.1016/j.envpol.2018.07.039 PMID:30373033 PMCID:PMC6211811

2017

2016

2015

2014

2013

2012

2011

2010

  • Andras IE, Eum SY, Zhong Y, Hennig B, Toborek M, Huang W. 2010. HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin. Mol Cell Neurosci 43(2):232-243. doi:10.1016/j.mcn.2009.11.004 PMID:19944163 PMCID:PMC2818553
  • Choi Y, Arzuaga X, Kluemper CT, Caraballo A, Toborek M, Hennig B. 2010. Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs. Environ Int 36(8):931-934. doi:10.1016/j.envint.2009.06.009 PMID:19608276 PMCID:PMC2889233
  • Choi Y, Seelbach MJ, Pu H, Eum SY, Chen L, Zhang B, Hennig B, Toborek M. 2010. Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression. Environ Health Perspect 118(7):976-981. doi:10.1289/ehp.0901751 PMID:20299304 PMCID:PMC2920918
  • Han S, Eum SY, Toborek M, Smart EJ, Hennig B. 2010. Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice. Toxicol Appl Pharmacol 246(1-2):74-82. doi:10.1016/j.taap.2010.04.009 PMID:20406653 PMCID:PMC2895770
  • Huang W, Rha GB, Chen L, Seelbach MJ, Zhang B, Andras IE, Bruemmer D, Hennig B, Toborek M. 2010. Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells. Am J Physiol Heart Circ Physiol 298(4):H1136-H1145. doi:10.1152/ajpheart.01126.2009 PMID:20139322 PMCID:PMC2853419
  • Majkova Z, Toborek M, Hennig B. 2010. The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants. J Cell Mol Med 14(10):2359-2370. doi:10.1111/j.1582-4934.2010.01064.x PMID:20406324 PMCID:PMC2965309
  • Seelbach MJ, Chen L, Powell A, Choi Y, Zhang B, Hennig B, Toborek M. 2010. Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation. Environ Health Perspect 118(4):479-484. doi:10.1289/ehp.0901334 PMID:20064788 PMCID:PMC2854723
  • Zhang B, Chen L, Swartz KR, Bruemmer D, Eum SY, Huang W, Seelbach MJ, Choi Y, Hennig B, Toborek M. 2010. Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke. J Neurosci Res 88(13):2859-2868. doi:10.1002/jnr.22450 PMID:20564349 PMCID:PMC2919635
  • Zheng Y, Toborek M, Hennig B. 2010. Epigallocatechin gallate mediated protection against tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependent. Metabolism-Clinical and Experimental 59(10):1528-1535. doi:10.1016/j.metabol.2010.01.018 PMID:20580034
  • Zhong Y, Hennig B, Toborek M. 2010. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. J Cereb Blood Flow Metab 30(3):522-533. doi:10.1038/jcbfm.2009.214 PMID:19794400 PMCID:PMC2949153

2009

  • Arzuaga X, Ren N, Stromberg AJ, Black EP, Arsenescu V, Cassis LA, Majkova Z, Toborek M, Hennig B. 2009. Induction of gene pattern changes associated with dysfunctional lipid metabolism induced by dietary fat and exposure to a persistent organic pollutant. Toxicol Lett 189(2):96-101. doi:10.1016/j.toxlet.2009.05.008 PMID:19467301 PMCID:PMC2729430
  • Eum SY, Andras IE, Hennig B, Toborek M. 2009. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicol Appl Pharmacol 240(2):299-305. doi:10.1016/j.taap.2009.07.022 PMID:19632255 PMCID:PMC2760772
  • Huang W, Eum SY, Andras IE, Hennig B, Toborek M. 2009. PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB J 23(5):1596-1606. doi:10.1096/fj.08-121624 PMID:19141539 PMCID:PMC2669424
  • Majkova Z, Smart EJ, Hennig B. 2009. Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicol Appl Pharmacol 237(1):1-7. doi:10.1016/j.taap.2009.02.016 PMID:19265715 PMCID:PMC2680936
  • Owens E, Toborek M, Hennig B. 2009. Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene. Bull Environ Contam Toxicol 83(1):4-7. doi:10.1007/s00128-009-9664-1 PMID:19214356

2008

  • Chen L, Yokel R, Hennig B, Toborek M. 2008. Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature. J Neuroimmune Pharmacol 3(4):286-295. doi:10.1007/s11481-008-9131-5 PMID:18830698 PMCID:PMC2771674
  • Lim EJ, Májková Z, Xu S, Bachas LG, Arzuaga X, Smart EJ, Tseng M, Toborek M, Hennig B. 2008. Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells. Chem Biol Interact 176(2-3):71-78. doi:10.1016/j.cbi.2008.08.007 PMID:18786521 PMCID:PMC2603293
  • Oesteriing E, Chopra N, Gavalas VG, Arzuaga X, Lim EJ, Sultana R, Butterfield DA, Bachas LG, Hennig B. 2008. Alumina nanoparticles induce expression of endothelial cell adhesion molecules. Toxicol Lett 178(3):160-166. doi:10.1016/j.toxlet.2008.03.011 PMID:18456438
  • Oesterling EG, Toborek M, Hennig B. 2008. Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway. Toxicol Appl Pharmacol 232(2):309-316. doi:10.1016/j.taap.2008.07.001 PMID:18671994 PMCID:PMC2633733
  • Shen H, Arzuaga X, Toborek M, Hennig B. 2008. Zinc nutritional status modulates expression of ahr-responsive p450 enzymes in vascular endothelial cells. Environ Toxicol Pharmacol 25(2):197-201. doi:10.1016/j.etap.2007.10.016 PMID:19255596 PMCID:PMC2346446
  • Shen H, Oesteriing E, Toborek M, MacDonald R, Hennig B. 2008. Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-KB and PPAR signaling. J Am Coll Nutr 27:577-587. PMID:18845708
  • Wang L, Lim EJ, Toborek M, Hennig B. 2008. The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. Metabolism 57(10):1328-39. PMID:18803934
  • Wang L, Reiterer G, Toborek M, Hennig B. 2008. Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. Chem Biol Interact 172(1):27-38. doi:10.1016/j.cbi.2007.11.003 PMID:18155686 PMCID:PMC2277485

2007

  • Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B. 2007. PPARalpha ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis. Cardiovasc Toxicol 7(4):264-272. doi:10.1007/s12012-007-9005-8 PMID:17955387
  • Hennig B, Ettinger AS, Jandacek RJ, Koo S, McClain CJ, Seifried H, Silverstone AE, Watkins B, Suk WA. 2007. Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environ Health Perspect 115(4):493-495. PMID:17450213
  • Hennig B, Oesterling EG, Toborek M. 2007. Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis. Nutrition, Metabolism & Cardiovascular Diseases 17(2):162-9. PMID:17306736

2006

  • Arzuaga X, Kluemper CT, Toborek M, Hennig B. 2006. The dietary flavonoids quercetin blocks PCB 77 induced pro-inflammatory responses in vascular endothelial cells. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B. 2006. PPARalpha activation disrupts PCB-induced proinflammatory signaling pathways in vascular endothelial cells. In: Society of Toxicology, 45th annual meeting, 2006. San Diego, CA.
  • Arzuaga X, Reiterer G, Majkova Z, Toborek M, Hennig B. 2006. PPARD agonists disrupt PCB-induced vascular endothelial cell activation. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Arzuaga X, Reiterer G, Majkova Z, Toborek M, Hennig B. 2006. Synthetic PPAR-alpha agonists protect against PCB 77 induced vascular endothelial cell activation. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Eum SY, Andras IE, Hennig B, Toborek M. 2006. PCBs alter tight junction protein distribution and expression in human brain microvessel endothelial cells. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Eum SY, Andras IE, Hennig B, Toborek M. 2006. Polychlorinated biphenyls disrupt tight junction protein expression in human brain microvessel endothelial cells. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Eum SY, Lee YW, Hennig B, Toborek M. 2006. Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells. Mol Cancer Res 4(6):361-70. PMID:16778083
  • Eum SY, Rha GB, Hennig B, Toborek M. 2006. cSRC-mediated interleukin-8 overexpression and migration of endothelial cells: implications in PCB-mediated tumor metastasis. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Hayashi K, Pu H, Andras IE, Eum SY, Yamauchi A, Hennig B, Toborek M. 2006. HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier. J Cereb Blood Flow Metab 26(8):1052-65. PMID:16395283
  • Hennig B, Arzuaga X, Majkova Z, Smart EJ, Toborek M. 2006. Endothelial cell dysfunction: environmental contaminants and nutritional implications. Atherosclerosis 7(3):444.
  • Hennig B, Lei W, Arzuaga X, Das Ghosh D, Viswanathan S, Toborek M. 2006. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling. J Nutr Biochem 17(11):766-772. PMID:16563718
  • Hennig B, Toborek M. 2006. Impact of nutrition on PCB toxicity. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Huang Z, Eum SY, Hennig B, Toborek M, Zhu H. 2006. Proteomic characterization of endothelial cell surface proteins upon PCB exposure. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Lei W, Toborek M, Hennig B. 2006. Omega-3 but not omega-6 fatty acids protect against TNF-alpha induced endothelial cell activation. FASEB J 20:A605.
  • Lim EJ, Xu S, Tseng M, Smart EJ, Toborek M, Hennig B. 2006. A role of caveolae in the uptake of PCB 77 in endothelial cells. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Majkova Z, Arzuaga X, Lim EJ, Smart EJ, Toborek M, Hennig B. 2006. Caveolin-1 plays a role in PCB-induced vascular endothelial cell inflammation. In: Society of Toxicology, 45th annual meeting, 2006. San Diego, CA.
  • Majkova Z, Arzuaga X, Smart EJ, Toborek M, Hennig B. 2006. Caveolin-1 knockout mice are protected from endothelial activation by coplanar PCBs. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Majkova Z, Lim EJ, Smart EJ, Toborek M, Hennig B. 2006. Role of caveolin-1 in PCB-induced vascular endothelial cell activation. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Oesterling EG, Arzuaga X, Lim EJ, Gavalas VG, Bachas LG, Toborek M, Hennig B. 2006. Manufactured nanosized alumina particle induced endothelial cell dysfunction: implication in vascular disease. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Reiterer G, Toborek M, Hennig B. 2006. Zinc and Cell Signaling During Inflammation: Implications in Atherosclerosis. Current Nutrition & Food Science 2(1):23-28.
  • Rha GB, Eum SY, Hennig B, Toborek M. 2006. c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line. Toxicol Sci 92(1):311-20. PMID:16611624
  • Shen H, Arzuaga X, Toborek M, Hennig B. 2006. Zinc nutritional status modulates PCB 77-induced proinflammatory responses in vascular endothelial cells. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Sipka SM, Eum SY, Pu H, Hennig B, Toborek M. 2006. Structure-function relationship of PCB-mediated induction of proinflammatory mediators in vivo. FASEB J 20:A641.
  • Sipka SM, Eum SY, Xu S, Gavalas VG, Hennig B, Toborek M. 2006. Oral administration of PCBs induces proinflammatory and prometastatic responses. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Toborek M, Hennig B. 2006. PCBs and cancer metastasis. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • Vandracek J, Umannova L, Kremar P, Neca J, Hennig B, Majkova Z, Machala M, Kozubik A. 2006. Interactions of fatty acids, lipid mediators and PCBs in liver epithelial cells. In: PCB Workshop, 4th, 2006. Zakopane, Poland.
  • . 2006. Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.

2005

  • Andras IE, Pu H, Tian J, Deli MA, Nath A, Hennig B, Toborek M. 2005. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J Cereb Blood Flow Metab 25(9):1159-1170. doi:10.1038/sj.jcbfm.9600115 PMID:15815581
  • Arzuaga X, Reiterer G, Majkova Z, Kilgore MW, Toborek M, Hennig B. 2005. 3,3'4,4'-tetrachlorobiphenyl disrupts PPAR signaling in vascular endothelial cells. In: Proceedings of the DIOXIN 2005 Conference, August 21-26. Toronto, Canada.
  • Eum SY, Lee YW, Hennig B, Toborek M. 2005. Role of EGF receptor/MAP kinases in activation of human microvascular endothelial cells by exposure to polychlorinated biphenyls. FASEB J 19:A1067.
  • Glauert HP, Lu Z, Kumar A, Bunaciu RP, Patel S, Tharappel JC, Stemm DN, Lehmler H, Lee EY, Robertson LW, Spear BT. 2005. Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats. J Nutr 135(2):283-286. PMID:15671227
  • Gosh DG, Viswanathan S, Toborek M, Hennig B. 2005. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3/AKT and ERK1/2 MARK signaling. FASEB J 19:A1006.
  • Hennig B, Majkova Z, Oesterling EG, Arzuaga X, Reiterer G, Toborek M. 2005. Proinflammatory mechanisms induced by PCBs: implications in vascular diseases. In: Proceedings of the DIOXIN 2005 Conference, August 21-26. Toronto, Canada.
  • Hennig B, Reiterer G, Majkova Z, Oesterling EG, Meerarani P, Toborek M. 2005. Modification of environmental toxicity by nutrients: implications in atherosclerosis. Cardiovasc Toxicol 5(2):153-160. PMID:16046791
  • Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart EJ, Robertson LW. 2005. Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor. Environ Health Perspect 113(1):83-87. PMID:15626652 PMCID:PMC1253714
  • Lee YW, Eum SY, Chen KC, Hennig B, Toborek M. 2005. Gene expression profile in interleukin-4-stimulated human vascular endothelial cells. Mol Med 10(1-6):19-27. PMID:15502879
  • Lei W, Toborek M, Hennig B. 2005. Different ratios of omega-6 to omega-3 fatty acids can modulate the pro-inflammatory response in endothelial cells mediated by TNF-?. J Am Coll Nutr 24:426.
  • Pu H, Tian J, Andras IE, Hayashi K, Flora G, Hennig B, Toborek M. 2005. HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK1/2 activation. J Cereb Blood Flow Metab 25(10):1325-1335. doi:10.1038/sj.jcbfm.9600125 PMID:15829913
  • Reiterer G, MacDonald R, Browning JD, Marrow J, Matveev SV, Daugherty A, Smart EJ, Toborek M, Hennig B. 2005. Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice. J Nutr 135(9):2114-2118. PMID:16140885
  • Wang L, Reiterer G, Toborek M, Hennig B. 2005. Different ratios of omega-6 to omega-3 fatty acids can modulate proinflammatory events in endothelial cells induced by TNF-D and environmental contaminants. FASEB J 19:A442.

2004

  • Deo SK. 2004. Exploring bioanalytical applications of assisted protein reassembly. Anal Bioanal Chem 379(3):383-390. PMID:15127176
  • Hennig B, Toborek M, Bachas LG, Suk WA. 2004. Emerging issues: nutritional awareness in environmental toxicology. J Nutr Biochem 15(4):194-195. PMID:15068811
  • Machala M, Blaha L, Lehmler H, Pliskova M, Majkova Z, Kapplova P, Sovadinova I, Vondracek J, Malmberg T, Robertson LW. 2004. Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells. Chem Res Toxicol 17(3):340-347. doi:10.1021/tx030034v PMID:15025504
  • Reiterer G, Toborek M, Hennig B. 2004. Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells. J Nutr 134(7):1711-1715. PMID:15226458
  • Toborek M, Hennig B. 2004. Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. J Nutr 134(4):771-775. PMID:15051824

2003

  • Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. 2003. PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis. Toxicol Sci 75(1):47-56. doi:10.1093/toxsci/kfg149 PMID:12805654
  • Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2003. Polychlorinated biphenyls (PCBs) as initiators in liver carcinogensis: resistant hepatocyte model. Toxicol Appl Pharmacol 186(1):55-62. PMID:12583993
  • Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. 2003. PCB 104 increases permeability of human microvascular endothelial cells: involvement of matrix metalloproteinases. FASEB J 17(5):A1082-A1082Part2Suppl.S.
  • Hennig B, Toborek M. 2003. Antioxidants and CVD: focus on the vascular endothelium. J Am Coll Nutr 22:462.
  • Hennig B, Toborek M. 2003. Cardiovascular disease: benefits and risks of n-3 and n-6 fatty acids. In: Proceedings of the Annual Meeting of the IFT (Institute of Food Technologists), 2003. Chicago, IL. pp.208.
  • Hennig B, Toborek M, Robertson LW. 2003. Nutrition and proinflammatory mechanisms of PCB toxicity in the vascular endothelium. Fresenius Environmental Bulletin 12(2):240-244.
  • Kania-Korwel I, Lehmler H, Robertson LW, Parkin S. 2003. 2,4,5-trichloro-1-iodobenzene. Acta Crystallogr B E59(Part7):o1048-o1049.
  • Kania-Korwel I, Robertson LW, Lehmler H, Parkin S. 2003. 2,4,6-Trichloroiodobenzene. Acta Crystallogr B E59(Part1):o1770-o1771.
  • Lee YW, Hennig B, Toborek M. 2003. Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells. Am J Physiol 284(1):H185-192. doi:10.1152/ajpheart.00524.2002 PMID:12388243
  • Lee YW, Park HJ, Son KW, Hennig B, Robertson LW, Toborek M. 2003. 2,2',4,6,6'-Pentachlorobiphenyl (PCB104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol Appl Pharmacol 189(1):1-10. PMID:12758055
  • Meerarani P, Reiterer G, Toborek M, Hennig B. 2003. The role of PPAR³ signaling in endothelial cell dysfunction induced by linoleic acid. FASEB J 17(4):A122-A122Part1Suppl.S.
  • Meerarani P, Reiterer G, Toborek M, Hennig B. 2003. Zinc modulates PPARgamma signaling and activation of porcine endothelial cells. J Nutr 133(10):3058-3064. PMID:14519784
  • Meerarani P, Smart EJ, Toborek M, Boissonneault GA, Hennig B. 2003. Cholesterol attenuates linoleic acid-induced endothelial cell activation. Metabolism 52(4):493-500. PMID:12701065
  • Ramadass P, Meerarani P, Toborek M, Robertson LW, Hennig B. 2003. Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells. Toxicol Sci 76(1):212-219. PMID:12970578
  • Ramadass P, Robertson LW, Toborek M, Meerarani P, Hennig B. 2003. Dietary phenolics modulate PCB-induced endothelial toxicity. FASEB J 17:A1361.
  • Reiterer G, Meerarani P, Toborek M, Hennig B. 2003. Zinc augments the anti-inflammatory properties of PPAR agonists in vascular endothelia cells. FASEB J 17(4):A304-A304Part1Suppl.S.
  • Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. 2003. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. J Am Coll Nutr 22(6):502-510. PMID:14684755
  • Viswanathan S, Smart EJ, Toborek M, Hennig B. 2003. CD 36 enhances long chain fatty acid-medicated oxidative stress: implications in atherosclerosis. FASEB J 17:A882-A883.

2002

  • Hennig B, Hammock BD, Slim RM, Toborek M, Viswanathan S, Robertson LW. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int J Hyg Environ Health 205(1-2):95-102. PMID:12018021
  • Hennig B, Meerarani P, Slim RM, Toborek M, Daugherty A, Silverstone AE, Robertson LW. 2002. Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol 181(3):174-183. PMID:12079426
  • Hennig B, Meerarani P, Toborek M, Daugherty A, Silverstone AE, Robertson LW. 2002. Proinflammatory properties of coplanar PCBs. Organohalogen Compounds 55:355-358.
  • Lee YW, Hennig B, Toborek M. 2002. Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells. FASEB J 16:A211.
  • Park HJ, Lee YW, Hennig B, Toborek M. 2002. Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-ºB-dependent pathway. Nutr Cancer 41:126-134. PMID:12094615
  • Reiterer G, Sali A, Meerarani P, Viswanathan S, Kelly L, Toborek M, Hennig B. 2002. The plant phenolics quercetin and resveratrol protect against linoleic acid-induced endothelial cell activation. FASEB J 16:A642.
  • Reiterer G, Sali A, Meerarani P, Viswanathan S, Toborek M, Hennig B. 2002. The role of PPAR³ in quercetin-mediated protection against endothelial cell activation. J Am Coll Nutr 21:479.
  • Toborek M, Lee YW, Garrido R, Kaiser S, Hennig B. 2002. Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. Am J Clin Nutr 75(1):119-125. PMID:11756069
  • Viswanathan S, Hammock BD, Meerarani P, Toborek M, Hennig B. 2002. Mechanisms of linoleic acid-induced endothelial activation: possible involvement of epoxide metabolites in mediating the inflammatory response. FASEB J 16:A157.

2001

  • Hennig B, Toborek M, McClain CJ. 2001. High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J Am Coll Nutr 20(2):97-105. PMID:11349944
  • Hennig B, Toborek M, Reiterer G, Majkova Z, Oesterling EG, Meerarani P, Robertson LW. 2001. Nutrition Modulates PCB Toxicity: Implications in Atherosclerosis. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY.
  • Lee YW, Hennig B, Yao J, Toborek M. 2001. Methamphetamine induces AP-1 and NF-kB binding and transactivation in human brain endothelial cells. J Neurosci Res 66(4):583-591. doi:10.1002/jnr.1248 PMID:11746378
  • Slim RM, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau C, Watkins BA, Viswanathan S, Hennig B. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 171(3):184-193. PMID:11243918
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2001. Cellular glutathione status modulates PCB-induced stress response and apoptosis in vascular endothelial cells. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.313-315.

2000

  • Hennig B, Meerarani P, Kaiser S, Toborek M. 2000. Inflammatory events and fatty acid-induced activation of vascular endothelial cells. FASEB J 14:A199.
  • Hennig B, Meerarani P, Ramadass P, Watkins BA, Toborek M. 2000. Fatty acid-mediated activation of vascular endothelial cells. Metabolism 49(8):1006-1013. PMID:10954018
  • Hennig B, Slim RM, Toborek M, Malecki A, Robertson LW. 2000. Effects of lipids and antioxidants on PCB-mediated dysfunction of vascular endothelial cells. Cent Eur J Public Health 8(supp):18-19. PMID:10943440
  • Hennig B, Slim RM, Toborek M, Watkins BA, Robertson LW. 2000. Modulation of PCB-induced endothelial activation by fatty acids and antioxidants. In: Proceedings of the 1st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY.
  • Hennig B, Toborek M. 2000. High-energy nutrients, fatty acids and endothelial cell function: implications in atherosclerosis. J Am Coll Nutr 19:678.
  • Hennig B, Toborek M, Boissonneault GA. 2000. Lipids inflammatory cytokines, and endothelial cell injury. Chapter 17 in: Nutrition and Immunology: Principles and Practice. Humana Press Inc., Totowa, NJ. pp.203-220.
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. Cellular glutathione status modulates PCB-induced stress response and apoptosis in porcine endothelial cells. In: Proceedings of the 39th Annual Meeting of the Society of Toxicology (SOT), March 19-23, 2000. Philadelphia, PA.
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. Cellular glutathione status modulates Polychlorinated Biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol Appl Pharmacol 166(1):36-42. PMID:10873716
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. PCB-induced stress response and apoptosis in vascular endothelial cells. In: Proceedings of the 1st PCB Workshop: Recent Advances in the Environmental Toxicology and Health Effects of PCBs (polychlorinated biphenyls), 2000. Lexington, KY.
  • Toborek M, Lee YW, Garrido R, Kaiser S, Hennig B. 2000. Dietary fatty acid-induced oxidative and inflammatory environments in endothelial cells. J Am Coll Nutr 19:684.

1999

  • Hennig B, Slim RM, Toborek M, Robertson LW. 1999. Linoleic acid amplifies polychlorinated biphenyl-mediated dysfunction of endothelial cells. J Biochem Mol Toxicol 13(2):83-91. PMID:9890193

1998

  • Chung BH, Hennig B, Cho B, Darnell BE. 1998. Effect of the fat composition of a single meal on the composition and cytotoxic potencies of lipolytically-releasable free fatty acids in postprandial plasma. Atherosclerosis 141(2):321-332. PMID:9862181
  • Hennig B, Slim RM, Toborek M, Robertson LW. 1998. Polychlorinated biphenyls (PCBs) and cardiovascular disease. Pol J Pharmacol 50:81-82.
  • Young VM, Toborek M, Yang F, McClain CJ, Hennig B. 1998. Effect of linoleic acid on endothelial cell inflammatory mediators. Metabolism 47:566-572. PMID:9591748

1997

  • Aziz SM, Toborek M, Hennig B, Endean E, Lipke DW. 1997. Polyamine regulatory processes and oxidative stress in monocrotaline-treated pulmonary artery endothelial cells. Cell Biol Int 21(12):801-812. PMID:9812344
  • Aziz SM, Toborek M, Hennig B, Mattson MP, Guo H, Lipke DW. 1997. Oxidative stress mediates monocrotaline-induced alterations in tenascin expression in pulmonary artery endothelial cells. International Journal of Biochemistry & Cell Biology 29:775-787. PMID:9251245
  • Blanc EM, Toborek M, Mark RJ, Hennig B, Mattson MP. 1997. Amyloid b-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells. J Neurochem 68:1870-1881. PMID:9109512
  • Connell P, Young VM, Toborek M, Cohen DA, Barve S, McClain CJ, Hennig B. 1997. Zinc attenuates tumor necrosis factor-mediated activation of transcription factors in endothelial cells. J Am Coll Nutr 16(5):411-417. PMID:9322188
  • Nicholas KN, Toborek M, Slim RM, Watkins BA, Chung BH, Oeltgen PR, Hennig B. 1997. Dietary cholesterol supplementation protects against endothelial cell dysfunction mediated by native and lipolyzed lipoproteins derived from rabbits fed high-corn oil diets. J Nutr Biochem 8:566-572.
  • Toborek M, Blanc EM, Kaiser S, Mattson MP, Hennig B. 1997. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis and apoptosis of cultured vascular endothelial cells. J Lipid Res 38:2155-2167. PMID:9374137
  • Toborek M, Feldman DL, Hennig B. 1997. Aortic antioxidant defense and lipid peroxidation in rabbits fed diets supplemented with different animal and plant fats. J Am Coll Nutr 16(1):32-38. PMID:9013431

1996

  • Gagliardi AR, Hennig B, Collins DC. 1996. Antiestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors. Anticancer Res 16(3A):1101-1106. PMID:8702220
  • Gorman L, Mercer LP, Hennig B. 1996. Growth requirements of endothelial cells in culture: variations in serum and amino acid concentrations. J Nutr 12(4):266-270. PMID:8862533
  • Hennig B, Toborek M, Joshi-Barve S, Barger SW, Barve S, Mattson MP, McClain CJ. 1996. Linoleic acid activates NF-ÇB and induces NF-ÇB-dependent transcription in cultured endothelial cells. Am J Clin Nutr 63(3):322-328. PMID:8602587
  • Hennig B, Toborek M, McClain CJ. 1996. Antiatherogenic properties of zinc: implications in endothelial cell metabolism. J Nutr 12:711-717. PMID:8936496
  • Hennig B, Toborek M, McClain CJ, Diana JN. 1996. Nutritional implications in vascular endothelial cell metabolism. J Am Coll Nutr 15(4):345-358. PMID:8829090
  • Ramasamy S, Lipke DW, Boissonneault GA, Guo H, Hennig B. 1996. Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. Atherosclerosis 120(1-2):199-208. PMID:8645361
  • Slim RM, Toborek M, Watkins BA, Boissonneault GA, Hennig B. 1996. Susceptibility to hepatic oxidative stress in rabbits fed different animal and plant fats. J Am Coll Nutr 15:289-294. PMID:8935445
  • Toborek M, Barger SW, Mattson MP, Barve S, McClain CJ, Hennig B. 1996. Linoleic acid and TNF-a cross-amplify oxidative injury and dysfunction of endothelial cells. J Lipid Res 37:123-135. PMID:8820108
  • Toborek M, Hennig B. 1996. Dietary methionine imbalance,endothelial cell dysfunction and atherosclerosis. Nutr Res 16:1251-1266.
  • Toborek M, Hennig B. 1996. Is endothelial cell autocrine production of tumor necrosis factor a mediator of lipid-induced endothelial dysfunction?. Med Hypotheses 47:377-382. PMID:8951801

1995

  • Cader AA, Butterfield DA, Watkins BA, Chung BH, Hennig B. 1995. Electron spin resonance studies of fatty acid-induced alterations in membrane fluidity in cultured endothelial cells. International Journal of Biochemistry & Cell Biology 27:665-673. PMID:7648422
  • Clair J, Talwalkar R, McClain CJ, Hennig B. 1995. Selective removal of zinc from cell culture media. Journal of Trace Elements and Experimental Medicine 7:143-151.
  • Gorman L, Toborek M, Hennig B. 1995. Cysteine deficiency potentiates fatty acid-mediated oxidative stress in cultured endothelial cells. Biochemistry Archives 11:211-219.
  • Hennig B, Lipke DW, Boissonneault GA, Ramasamy S. 1995. Role of fatty acids and eicosanoids in modulating proteoglycan metabolism in endothelial cells. Prostaglandins Leukot. Essential Fatty Acids 53:315-324. PMID:8596769
  • Hennig B, Toborek M, Boissonneault GA, Shantha NC, Decker EA, Oeltgen PR. 1995. Animal and plant fats selectively modulate oxidizability of rabbit LDL and LDL-mediated disruption of endothelial barrier function. J Nutr 125(8):2045-2054. PMID:7643238
  • Hennig B, Toborek M, Mattson MP, Gupta RC, Barger SW, Connell P, Robertson LW. 1995. Environmental chemical-mediated endothelial cell dysfunction: Implications in atherosclerosis. FASEB J 9:A323.
  • McClain CJ, Morris P, Hennig B. 1995. Zinc and endothelial function. J Nutr 11:117-120. PMID:7749257
  • Ramasamy S, Lipke DW, McClain CJ, Hennig B. 1995. Tumor necrosis factor reduces proteoglycan synthesis in cultured endothelial cells. Journal of Cellular Physiology 162:119-126. PMID:7814444
  • Ramasamy S, Wang E, Hennig B, Merrill AH. 1995. Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol Appl Pharmacol 133(2):343-348. PMID:7645031
  • Toborek M, Barger SW, Mattson MP, Espandiari P, Robertson LW, Hennig B. 1995. Exposure to polychlorinated biphenyls causes endothelial cell dysfunction. J Biochem Toxicol 10(4):219-226. doi:10.1002/jbt.2570100406 PMID:8568836
  • Toborek M, Barger SW, Mattson MP, McClain CJ, Hennig B. 1995. Role of glutathione redox cycle in TNF-alpha-mediated endothelial cell dysfunction. Atherosclerosis 117(2):179-188. PMID:8801863
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Last Reviewed: October 07, 2024