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Boston University: Dataset Details, ID=GSE19298

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Superfund Research Program

Estrogen Receptor-Arylhydrocarbon Receptor Interactions in the CNS

Project Leader: Gloria V. Callard
Grant Number: P42ES007381
Funding Period: 2000-2012

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Title: Gene expression timecourse in zebrafish whole eye in response to optic nerve crush

Accession Number: GSE19298

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE19298

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Danio rerio

Summary: It is well-established that neurons in the adult mammalian central nervous system are terminally differentiated and, if injured, will be unable to regenerate their connections. In contrast to mammals, zebrafish and other teleosts display a robust neuroregenerative response. Following optic nerve crush (ONX), retinal ganglion cells (RGC) regrow their axons to synapse with topographically correct targets in the optic tectum, such that vision is restored in ~21 days. What accounts for these differences between teleostean and mammalian responses to neural injury is not fully understood. A time course analysis of global gene expression patterns in the zebrafish eye after optic nerve crush can help to elucidate cellular and molecular mechanisms that contribute to a successful neuroregeneration. We used microarrays to detail the global gene expression patterns underlying a successful regeneration or the optic nerve following injury.

Publication(s) associated with this dataset:
  • McCurley A, Callard GV. 2010. Time course analysis of gene expression patterns in zebrafish eye during optic nerve regeneration. J Neurosci 17:13. PMID:20740047 PMCID:PMC2926816
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