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Project Publications: Boston University: Estrogen Receptor-Arylhydrocarbon Receptor Interactions in the CNS

Superfund Research Program

Estrogen Receptor-Arylhydrocarbon Receptor Interactions in the CNS

Project Leader: Gloria V. Callard
Grant Number: P42ES007381
Funding Period: 2000-2012

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  • Cotter KA, Nacci DE, Champlin D, Yeo AT, Gilmore TD, Callard GV. 2016. Adaptive significance of ERα splice variants in killifish (Fundulus heteroclitus) resident in an estrogenic environment. Endocrinology 157(6):2294-2308. doi:10.1210/en.2016-1052 PMID:27070100


  • Cotter KA, Nacci DE, Champlin D, Chuprin J, Callard GV. 2015. Cloning of multiple ERα mRNA variants in killifish (Fundulus heteroclitus), and differential expression by tissue type, stage of reproduction, and estrogen exposure in fish from polluted and unpolluted environments. Aquat Toxicol 159:184-197. doi:10.1016/j.aquatox.2014.12.012 PMID:25550165 PMCID:PMC4300264


  • Callard GV, Tarrant AM, Novillo-Villajos A, Yacci P, Ciaccia L, Vajda S, Chuang G, Kozakov D, Greytak SR, Sawyer SJ, Hoover CA, Cotter KA. 2011. Evolutionary origins of the estrogen signaling system: Insights from amphioxus. Psychiatr Pol 127:176-188. doi:10.1016/j.jsbmb.2011.03.022 PMID:21514383 PMCID:PMC3179578


  • McCurley A, Callard GV. 2010. Time course analysis of gene expression patterns in zebrafish eye during optic nerve regeneration. J Neurosci 17:13. PMID:20740047 PMCID:PMC2926816



  • Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618
  • Engel KB, Callard GV. 2007. Endocrinology of Leydig cells in nonmammalian vertebrates. Chapter 15 in: The Leydig Cell in Health and Disease. Humana Press, pp.207-224.
  • Greytak SR, Callard GV. 2007. Cloning of three estrogen receptors (ER) from killifish (Fundulus heteroclitus): differences in populations from polluted and reference environments. Gen Comp Endocrinol 150(1):174-88. PMID:16962596
  • Kitana N, Won S, Callard IP. 2007. Reproductive deficits in male freshwater turtle Chrysemys picta from Cape Cod, Massachusetts. Biol Reprod 76(3):346-52. PMID:17123946


  • Sawyer SJ, Gerstner KA, Callard GV. 2006. Development of a real time PCR assay for the differential detection and quantification of cytochrome P450 aromatase isoforms in zebrafish: tissue distribution, sex differences, developmental programming, and estrogen regulation. Gen Comp Endocrinol 147(2):108-117.
  • Sawyer SJ, Gerstner KA, Callard GV. 2006. Real-time PCR analysis of cytochrome P450 aromatase expression in zebrafish: gene specific tissue distribution, sex differences, developmental programming, and estrogen regulation. Gen Comp Endocrinol 147(2):108-17. PMID:16458310
  • Shipley JM, Waxman DJ. 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene. Toxicol Appl Pharmacol 213(2):87-97. PMID:16257430
  • Tarrant AM, Greytak SR, Callard GV, Hahn ME. 2006. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. J Mol Endocrinol 37(1):105-20. PMID:16901928


  • Chang TK, Waxman DJ. 2005. Pregnane X receptor-mediated transcription. Methods Enzymol 400:588-598. doi:10.1016/S0076-6879(05)00033-9 PMID:16399372
  • Custodia-Lora N, Novillo A, Callard IP. 2005. Synergistic role for pituitary growth hormone in the regulation of hepatic estrogen and progesterone receptors and vitellogenesis in female freshwater turtles, Chrysemys picta. Gen Comp Endocrinol 140:25-32. PMID:15596068
  • Greytak SR, Champlin D, Callard GV. 2005. Isolation and characterization of two cytochrome P450 aromatase forms in killifish (Fundulus heteroclitus): differential expression in fish from polluted and unpolluted environments. Aquat Toxicol 71(4):371-389. doi:10.1016/j.aquatox.2004.12.007 PMID:15710484
  • Kumar S, Chen C, Waxman DJ, Halpert JR. 2005. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. J Biol Chem 280(20):19569-19575. doi:10.1074/jbc.M500158200 PMID:15774478
  • Novillo A, Won S, Li C, Callard IP. 2005. Changes in nuclear receptor and vitellogenin gene expression in response to steroids and heavy metal in Caenorhabditis elegans. Integr Comp Biol 45:61-71. PMID:21676746
  • Rie MT, Kitana N, Lendas KA, Won S, Callard IP. 2005. Reproductive endocrine disruption in a sentinel species (Chrysemys picta) on Cape Cod, Massachusetts. Arch Environ Contam Toxicol 48(2):217-224. PMID:15719200
  • Ryu H, Emberley JK, Schlezinger JJ, Allan LL, Na S, Sherr DH. 2005. Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway. Mol Pharmacol 68(4):1087-1096. PMID:16014577
  • Sheu S, Kaya T, Waxman DJ, Vajda S. 2005. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. Biochemistry 44(4):1193-1209. doi:10.1021/bi048032c PMID:15667213
  • Won S, Novillo A, Custodia N, Rie MT, Fitzgerald K, Osada M, Callard IP. 2005. The fresh water mussel (Elliptic complanata) as a sentinel species: vitellogenin and steroid receptors. Integr Comp Biol 45:72-80.


  • Callard GV, Tchoudakova AV, Kishida M, Wood E. 2001. Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. Psychiatr Pol 79(1-5):305-314. PMID:11850237
  • Kishida M, Callard GV. 2001. Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development. Endocrinology 142(2):740-750. doi:10.1210/endo.142.2.7928 PMID:11159846
  • Kishida M, McLellan M, Miranda JA, Callard GV. 2001. Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio). Comp Biochem Physiol 129(2-3):261-268. PMID:11399458
  • Mann KK, Doerre S, Schlezinger JJ, Sherr DH, Quadri SA. 2001. The role of NF-kB as a survival factor in environmental chemical-induced preB cell apoptosis. Mol Pharmacol 59(2):302-309. PMID:11160867
  • Tchoudakova AV, Kishida M, Wood E, Callard GV. 2001. Promoter characteristics of two cyp19 genes differentially expressed in the brain and ovary of teleost fish. Psychiatr Pol 78(5):427-439. PMID:11738553
  • Zhao J, Mak P, Tchoudakova AV, Callard GV, Chen S. 2001. Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatatase isozymes. Gen Comp Endocrinol 123(2):180-191. PMID:11482939
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