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University of New Mexico: Dataset Details, ID=doi:10.6073/pasta/00830d488944eaddf25b89ebb86cebf0

Superfund Research Program

Mechanisms of Immune Dysregulation Produced by Uranium, Arsenic and Metal Mixtures

Project Leader: Ke Jian Liu
Grant Number: P42ES025589
Funding Period: 2017-2022
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Title: Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice

Accession Number: doi:10.6073/pasta/00830d488944eaddf25b89ebb86cebf0

Link to Dataset:

Repository: EDI Data Portal (Environmental Data Initiative)

Data Type(s): Exposure Data

Organism(s): Mus musculus

Summary: High levels of uranium (U) exist in soil, water, and air in the Southwestern United States due, in part, to waste generated from more than 160,000 abandoned hard rock mines located in this region. As a result, many people living in this region are chronically exposed to U at levels that have been linked to detrimental health outcomes. In an effort to establish a relevant in vivo mouse model for future U immunotoxicity studies, we evaluated the tissue distribution of U in immune organs; blood, bone marrow, spleen, and thymus, as well as femur bones, kidneys, and liver, following a 60-d drinking water exposure to uranyl acetate (UA) in male and female C57BL/6J mice. Following the 60-d exposure, there was low overall tissue retention of U (<0.01 ) at both the 5 and the 50 ppm (mg/L) oral concentrations. In both male and female mice, there was limited U accumulation in immune organs. U only accumulated at low concentrations in the blood and bone marrow of male mice (0.6 and 16.8 ng/g, respectively). Consistent with previous reports, the predominant sites of U accumulation were the femur bones (350.1 and 399.0 ng/g, respectively) and kidneys (134.0 and 361.3 ng/g, respectively) of male and female mice. Findings from this study provide critical insights into the distribution and retention of U in lymphoid tissues following chronic drinking water exposure to U. This information will serve as a foundation for immunotoxicological assessments of U, alone and in combination with other metals.

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