Superfund Research Program

Mechanisms of Immune Dysregulation Produced by Uranium, Arsenic and Metal Mixtures

Project Leader: Ke Jian Liu
Grant Number: P42ES025589
Funding Period: 2017-2022

Project-Specific Links

Publications

2022

• Cooper KL, Volk L, Dominguez DR, Duran AD, Liu K, Hudson LG. 2022. Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic. Toxicol Appl Pharmacol 434:115799. doi:10.1016/j.taap.2021.115799 PMID:34798142

2021

• Duan M, Speer RM, Ulibarri J, Liu K, Mao P. 2021. Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches. DNA Repair (Amst) 103:103126. doi:10.1016/j.dnarep.2021.103126 PMID:33894524 PMCID:PMC8205993
• Feric Z, Agostini NB, Beene D, Signes-Pastor AJ, Halchenko Y, Watkins DJ, MacKenzie D, Karagas MR, Manjourides J, Alshawabkeh AN, Kaeli D. 2021. A secure and reusable software architecture for supporting online data harmonization. IEEE Access 2801-2812. doi:10.1109/BigData52589.2021.9671538
• Hayek EE, Medina S, Guo J, Noureddine A, Zychowski KE, Hunter R, Velasco CA, Wiesse M, Maestas-Olguin A, Brinker CJ, Brearley AJ, Spilde MN, Howard T, Lauer FT, Herbert G, Ali AS, Burchiel SW, Campen M, Cerrato JM. 2021. Uptake and toxicity of respirable carbon-rich uranium-bearing particles: Insights into the role of particulates in uranium toxicity. Environ Sci Technol 55(14):9949-9957. doi:10.1021/acs.est.1c01205 PMID:34235927 PMCID:PMC8413144
• Medina S, Bolt AM, Zhou X, Wan G, Xu H, Lauer FT, Liu K, Burchiel SW. 2021. Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors. Toxicol Lett 350:111-120. doi:10.1016/j.toxlet.2021.07.008 PMID:34274428 PMCID:PMC8487637
• Medina S, Zhou X, Lauer FT, Zhang H, Liu K, Lewis JL, Burchiel SW. 2021. Modulation of PARP activity by Monomethylarsonous (MMA +3) acid and uranium in mouse thymus. Toxicol Appl Pharmacol 411:115362. doi:10.1016/j.taap.2020.115362 PMID:33279514 PMCID:PMC7855914
• Speer RM, Toyoda JH, Croom-Perez TJ, Liu K, Wise Sr. JP. 2021. Particulate hexavalent chromium inhibits E2F1 leading to reduced RAD51 nuclear foci formation in human lung cells. Toxicol Sci 181(1):35-46. doi:10.1093/toxsci/kfab019 PMID:33677506 PMCID:PMC8081024
• Yin K, Lee J, Liu Z, Kim H, Martin DR, Wu D, Liu M, Xue X. 2021. Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production. Cell Death Differ 28(8):doi:10.1038/s41418-021-00760-9 PMID:33723373 (ahead of print)
• Zhou X, Speer RM, Volk L, Hudson LG, Liu K. 2021. Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins. Semin Cancer Biol 76:86-98. doi:10.1016/j.semcancer.2021.05.009 PMID:33984503 PMCID:PMC8578584
• Zhou X, Xue B, Medina S, Burchiel SW, Liu K. 2021. Uranium directly interacts with the DNA repair protein poly (ADP-ribose) polymerase 1. Toxicol Appl Pharmacol 410:115360. doi:10.1016/j.taap.2020.115360 PMID:33279515 PMCID:PMC7775282

2020

• Medina S, Lauer FT, Castillo EF, Bolt AM, Ali AS, Liu K, Burchiel SW. 2020. Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice. Toxicol Appl Pharmacol 403:doi:10.1016/j.taap.2020.115155 PMID:32710956
• Zhou X, Medina S, Bolt AM, Zhang H, Wan G, Xu H, Lauer FT, Wang S, Burchiel SW, Liu K. 2020. Inhibition of red blood cell development by arsenic-induced disruption of GATA-1. Sci Rep 10(1):19055. doi:10.1038/s41598-020-76118-x PMID:33149232 PMCID:PMC7643154

2019

• Bolt AM, Medina S, Lauer FT, Liu K, Burchiel SW. 2019. Minimal uranium immunotoxicity following a 60-day drinking water exposure to uranyl acetate in male and female C57BL/6J mice. Toxicol Appl Pharmacol 372:33-39. doi:10.1016/j.taap.2019.04.003 PMID:30978399
• Xue X, Falcon DM. 2019. The role of immune cells and cytokines in intestinal wound healing. Int J Mol Sci 20:doi:10.3390/ijms20236097 PMID:31816903 PMCID:PMC6929186

2018

• Bolt AM, Medina S, Lauer FT, Xu H, Ali AS, Liu K, Burchiel SW. 2018. Minimal uranium accumulation in lymphoid tissues following an oral 60-day uranyl acetate exposure in male and female C57BL/6J mice. PLoS One 13(10):e0205211. doi:10.1371/journal.pone.0205211 PMID:30356336 PMCID:PMC6200214