Title: Dataset of reverse osmosis membrane transport properties calculated with and without assumptions about concentration polarization and solute rejection and the errors associated with each assumption

Accession Number: doi: 10.1016/j.dib.2022.108538

Link to Dataset: https://doi.org/10.1016/j.dib.2022.108538

Repository: Other Repository

Summary: Reactive aldehydes arise as by-products of metabolism, and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly shortened lifespans and develop leukemia. Hematopoiesis is profoundly disrupted, with a reduction of hematopoietic stem cells and also common lymphoid progenitors causing a severely depleted acquired immune system. We show that formaldehyde is the common substrate of ALDH2 and ADH5, and establish methods to quantify elevated blood formaldehyde and formaldehyde-DNA adducts in tissues. Bone marrow derived progenitors actively engage DNA repair but also imprint a formaldehyde-driven mutation signature similar to ageing-associated human cancer mutation signatures. Furthermore, we identify analogous genetic defects in children causing a new inherited bone marrow failure and pre-leukemic syndrome. Endogenous formaldehyde clearance alone is therefore critical for hematopoiesis and in limiting mutagenesis in somatic tissues.

Publication(s) associated with this dataset:

• Armstrong MD, Vickers R, Coronell Nieto O. 2022. Dataset of reverse osmosis membrane transport properties calculated with and without assumptions about concentration polarization and solute rejection and the errors associated with each assumption. Data Brief 44:108538. doi:10.1016/j.dib.2022.108538 PMID:36060824 PMCID:PMC9436753