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Your Environment. Your Health.

Program Publications: University of North Carolina-Chapel Hill: The UNC Chapel Hill Superfund Research Program

Superfund Research Program

The UNC Chapel Hill Superfund Research Program

Center Director: Rebecca C. Fry
Grant Number: P42ES031007
Funding Period: 2020-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's Twitter page


  • Silveyra P, Al Houssein H, Rebuli ME. Sex and Gender Differences In The Susceptibility to Environmental Exposures. Chapter 9 in: Sex-Based Differences in Lung Physiology. Springer, (accepted for publication)


  • Atkinson AJ, Armstrong MD, Eskew JT, Coronell Nieto O. 2021. 2-Aminoimidazole reduces fouling and improves membrane performance. J Memb Sci 629:119262. doi:10.1016/j.memsci.2021.119262 PMID:34366551 PMCID:PMC8345324
  • Beaudry MS, Wang J, Kieran T, Thomas J, Bayona-Vasquez NJ, Gao B, Devault A, Brunelle B, Lu K, Wang J, Rhodes O, Glenn TC. 2021. Improved microbial community characterization of 16S rRNA via metagenome hybridization capture enrichment. Front Microbiol doi:10.3389/fmicb.2021.644662 PMID:33986735 PMCID:PMC8110821
  • Chang Y, Rager JE, Tilton SC. 2021. Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium. Chem Res Toxicol 34(6):1445-1455. doi:10.1021/acs.chemrestox.0c00333 PMID:34048650
  • Chi L, Tu P, Ru H, Lu K. 2021. Studies of xenobiotic-induced gut microbiota dysbiosis: From correlation to mechanisms. Gut Microbes 13:19. doi:10.1080/19490976.2021.1921912 PMID:34313531 PMCID:PMC8346244
  • Clark J, Avula V, Ring C, Eaves LA, Howard T, Santos HP, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2021. Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes. Toxicol Sci 183(2):269-284. doi:10.1093/toxsci/kfab089 PMID:34255065 PMCID:PMC8478332
  • Douillet C, Ji J, Meenakshi IL, Lu K, Pardo-Manuel de Villena F, Fry RC, Styblo M. 2021. Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic. Toxicology 452:152696. doi:10.1016/j.tox.2021.152696 PMID:33524430 PMCID:PMC7914223
  • Escobar YH, Morrison CB, Chen Y, Hickman E, Love CA, Rebuli ME, Surratt JD, Ehre C, Jaspers I. 2021. Differential responses to e-cig generated aerosols from humectants and different forms of nicotine in epithelial cells from non-smokers and smokers. Am J Physiol Lung Cell Mol Physiol 320:L1064-L1073. doi:10.1152/ajplung.00525.2020 PMID:33825493 PMCID:PMC8285624
  • Fry RC, Bulka C, Avula V. 2021. Associations of exposure to perfluoroalkyl substances individually and in mixtures with persistent infections: Recent findings from NHANES 1999-2016. Environ Pollut 275:116619. doi:10.1016/j.envpol.2021.116619 PMID:33578314 PMCID:PMC7957906
  • Ghiuzeli CM, Styblo M, Saunders RJ, Calabro A, Budman D, Allen S, Devoe C, Dhingra R. 2021. The pharmacokinetics of therapeutic arsenic trioxide in acute promyelocytic leukemia patients. Leuk Lymphoma doi:10.1080/10428194.2021.1978084 PMID:34689693 (ahead of print)
  • Gray K, Triana V, Lindsey M, Richmond B, Hoover AG, Wiesen C. 2021. Knowledge and beliefs associated with environmental health literacy: A case study focused on toxic metals contamination of well water. Int J Environ Res Public Health 18(17):9298. doi:10.3390/ijerph18179298 PMID:34501888 PMCID:PMC8430820
  • Kingsbury R, Hegde M, Wang J, Kusoglu A, You W, Coronell Nieto O. 2021. Tunable anion exchange membrane conductivity and permselectivity via non-covalent, hydrogen bond cross-linking. ACS Appl Mater Interfaces doi:10.1021/acsami.1c15474 PMID:34705410 (ahead of print)
  • Lai Y, Liu C, Chi L, Ru H, Lu K. 2021. High-resolution metabolomics of 50 neurotransmitters and tryptophan metabolites in feces, serum, and brain tissues using UHPLC-ESI-Q exactive mass spectrometry. ACS Omega doi:10.1021/acsomega.0c05789 PMID:33817468 PMCID:PMC8014936
  • Lai Y, Liu C, Yang Y, Hsiao Y, Ru H, Lu K. 2021. High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice. Nat Commun 12:PMID:34667167
  • Liu Y, Wu Y, Zhang J, Zhou H. 2021. Cox regression analysis for distorted covariates with an unknown distortion function. Biom J doi:10.1002/bimj.202000209 PMID:33687092 (ahead of print)
  • Manuck TA, Lai Y, Ru H, Glover AV, Rager JE, Fry RC, Lu K. 2021. Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth. Am J Obstet Gynecol doi:10.1016/j.ajogmf.2021.100393 PMID:33991707 (ahead of print)
  • Obeidy C, Sharma A. 2021. 2021 Congressional Visits Day Goes Virtual. 66(5):24-26. (non-peer reviewed)
  • Rebuli ME, Brocke SA, Jaspers I. 2021. Impact of inhaled pollutants on response to viral infection in controlled exposures. Journal of Allergy and Clinical Immunology doi:10.1016/j.jaci.2021.07.002 PMID:34252446 (ahead of print)
  • Rebuli ME, Glista-Baker E, Hoffman JR, Duffney PF, Robinette C, Speen AM, Pawlak EA, Dhingra R, Noah TL, Jaspers I. 2021. Electronic-cigarette use alters nasal mucosal immune response to live-attenuated influenza virus: A clinical trial. Am J Respir Cell Mol Biol 64(1):126-137. doi:10.1165/rcmb.2020-0164OC PMID:33095645 PMCID:PMC7781000
  • Ring C, Sipes N, Hsieh J, Carberry C, Koval L, Klaren WD, Harris M, Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high-throughput toxicokinetics. Comput Toxicol 18:doi:10.1016/j.comtox.2021.100166 PMID:34013136 PMCID:PMC8130852
  • Ryan NM, Hess JA, Pardo-Manuel de Villena F, Leiby BE, Shimada A, Yu L, Yarmahmoodi A, Petrovsky N, Zhan B, Bottazzi ME, Makepeace BL, Lustigman S, Abraham D. 2021. Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. NPJ Vaccines 6(1):17. doi:10.1038/s41541-020-00276-2 PMID:33500417 PMCID:PMC7838260
  • Stone J, Sutrave P, Gascoigne E, Givens MB, Fry RC, Manuck TA. 2021. Exposure to toxic metals and per- and polyfluoroalkyl substances and the risk of preeclampsia and preterm birth in the United States: A review. Am J Obstet Gynecol doi:10.1016/j.ajogmf.2021.100308 PMID:33444805 (ahead of print)
  • Styblo M, Venkatratnam A, Fry RC, Thomas DJ. 2021. Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects. Arch Toxicol doi:10.1007/s00204-021-03028-w PMID:33768354 (ahead of print)
  • van der Lelie D, Oka A, Taghavi S, Umeno J, Fan T, Merrell KE, Watson SD, Ouellette L, Liu B, Awoniyi M, Lai Y, Chi L, Lu K, Henry CS, Sartor RB. 2021. Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis. Nat Commun 12:3105. doi:10.1038/s41467-021-23460-x PMID:34050144
  • Venkatratnam A, Marable CA, Keshava AM, Fry RC. 2021. Relationships among inorganic arsenic, nutritional status CpG methylation and microRNAs: A review of the literature. Epigenet Insights 14:doi:10.1177/2516865721989719 PMID:33615137 PMCID:PMC7868494
  • Wang J, Armstrong MD, Grzebyk K, Vickers R, Coronell Nieto O. 2021. Effect of feed water pH on the partitioning of alkali metal salts from aqueous phase into the polyamide active layers of reverse osmosis membranes. Environ Sci Technol 55(5):3250-3259. doi:10.1021/acs.est.0c06140 PMID:33600153 PMCID:PMC7949323
  • Whitaker AH, Austin RE, Holden KL, Jones JL, Michel FM, Peak D, Thompson A, Duckworth O. 2021. The structure of natural biogenic iron (oxyhydr)oxides formed in circumneutral pH environments. Geochim Cosmochim Acta 308:237-255. doi:10.1016/j.gca.2021.05.059 PMID:34305159 PMCID:PMC8294128
  • Xue J, Chi L, Tu P, Lai Y, Liu C, Ru H, Lu K. 2021. Detection of gut microbiota and pathogen produced N-acyl homoserine in host circulation and tissues. NPJ Biofilms Microbiomes 7(1):53. doi:10.1038/s41522-021-00224-5 PMID:34183673 PMCID:PMC8239043
  • Yan F, Zhu L, Liu Y, Cai J, Zhou H. 2021. Semiparametric regression based on quadratic inference function for multivariate failure time data with auxiliary information. Lifetime Data Analysis 27:269-299. doi:10.1007/s10985-020-09513-1 PMID:33420545 PMCID:PMC7943434
  • Yang Y, Chi L, Lai Y, Hsiao Y, Ru H, Lu K. 2021. The gut microbiome and arsenic-induced disease-iAs metabolism in mice. Curr Environ Health Rep doi:10.1007/s40572-021-00305-9 PMID:33852125 (ahead of print)
  • Yu J, Zhou H, Cai J. 2021. Accelerated failure time model for data from outcome-dependent sampling. Lifetime Data Analysis 27:15-37. doi:10.1007/s10985-020-09508-y PMID:33044612 PMCID:PMC7856009
  • Zhang J, Zhou H, Liu Y, Cai J. 2021. Conditional screening for ultrahigh-dimensional survival data in case-cohort studies. Lifetime Data Analysis doi:10.1007/s10985-021-09531-7 PMID:34417679 (ahead of print)
  • Zhou Q, Cai J, Zhou H. 2021. Semiparametric regression analysis of case-cohort studies with multiple interval-censored disease outcomes. Stat Med doi:10.1002/sim.8962 PMID:33783001 (ahead of print)


  • Douillet C, Koller BH, Styblo M. 2020. Metabolism of inorganic arsenic in mice lacking genes encoding GST-P, GST-M, and GST-T. Chem Res Toxicol 33(8):2043-2046. doi:10.1021/acs.chemrestox.0c00273 PMID:32700902 PMCID:PMC7802361
  • Eaves LA, Nguyen HT, Rager JE, Sexton K, Howard T, Smeester L, Freedman AN, Aagaard KM, Shope C, Lefer B, Flynn JH, Erickson MH, Fry RC, Vizuete W. 2020. Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures. Environ Sci Technol 1380713816.
  • Eaves LA, Phookphan P, Rager JE, Bangma J, Santos H, Smeester L, O'Shea TM, Fry RC. 2020. A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta. Epigenomics 12:doi:10.2217/epi-2020-0062 PMID:32901510
  • Fry RC, ed. 2020. Environmental epigenetics in toxicology and public health
  • Giusti-Rodriguez P, Xenakis JG, Crowley JJ, Nonneman RJ, DeCristo DM, Rogala AR, Quackenbush CR, Miller DR, Shaw GD, Zhabotynsky V, Sullivan PF, Pardo-Manuel de Villena F, Zou F. 2020. Antipsychotic behavioral phenotypes in the mouse Collaborative Cross recombinant inbred inter-crosses (RIX). G3 10:doi:10.1534/g3.120.400975 PMID:32694196 (accepted for publication)
  • Gomez JL, Chen A, Diaz M, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry RC, Rager JE, Cohn L, Alexis N, Chupp GL. 2020. A network of sputum microRNAs is associated with neutrophilic airway inflammation in asthma. Am J Respir Crit Care Med 1:51-64. doi:10.1164/rccm.201912-2360OC PMID:32255668 PMCID:PMC7328332
  • Graham JB, Swarts JL, Leist SR, Schafer A, Menachery VD, Gralinski L, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Heise MT, Baric RS, Lund JM. 2020. Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection. bioRxivorg doi:10.1101/2020.09.21.306837 PMID:32995791 PMCID:PMC7523117 (ahead of print)
  • Gray K, LePrevost CE, Cope W. 2020. Anglers' views on using signs to communicate fish consumption advisories. Fisheries 10:doi:10.1002/fsh.10463
  • Gu B, Shorter JR, Williams L, Bell TA, Hock P, Dalton KA, Pan Y, Miller DR, Shaw GD, Philpot BD, Pardo-Manuel de Villena F. 2020. Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. Epilepsia 9:2010-2021. doi:10.1111/epi.16617 PMID:32852103
  • Hillis DA, Yadgary L, Weinstock GM, Pardo-Manuel de Villena F, Pomp D, Fowler AS, Xu S, Chan F, Garland T. 2020. Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice. Genetics 216:781-804. doi:10.1534/genetics.120.303668
  • Hsiao Y, Liu C, Chi L, Yang Y, Lu K. 2020. Effects of gut microbiome on carcinogenic DNA damage. Chem Res Toxicol 33:2130-2138. doi:10.1021/acs.chemrestox.0c00142 PMID:32677427
  • Huda M, VerHague M, Albright J, Smallwood T, Bell TA, Que E, Miller DR, Roshanravan B, Allayee H, Pardo-Manuel de Villena F, Bennett BJ. 2020. Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice. G3 7:2529-2541. doi:10.1534/g3.120.401275 PMID:32467129
  • Koller BH, Snouwaert JN, Douillet C, Jania LA, El-Masri HA, Thomas DJ, Styblo M. 2020. Arsenic metabolism in mice carrying a BORCS7/AS3MT locus humanized by syntenic replacement. Environ Health Perspect 128(8):87003. doi:10.1289/EHP6943 PMID:32779937 PMCID:PMC7418654
  • Lebow-Skelley E, Yelton S, Janssen B, Erdei E, Pearson MA. 2020. Identifying Issues and Priorities in Reporting Back Environmental Health Data. Int J Environ Res Public Health 17:doi:10.3390/ijerph17186742 PMID:32947900 PMCID:PMC7557638
  • Li Y, Douillet C, Huang MC, Beck R, Sumner SJ, Styblo M. 2020. Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets. Arch Toxicol 94(6):1955-1972. doi:10.1007/s00204-020-02729-y PMID:32277266
  • Payton A, Clark J, Eaves LA, Santos H, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2020. Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling. Reprod Toxicol 96:221-230. doi:10.1016/j.reprotox.2020.07.007 PMID:32721520 PMCID:PMC7855285
  • Rager JE, Bangma J, Carberry C, Chao A, Grossman J, Lu K, Manuck TA, Sobus JR, Szilagyi JT, Fry RC. 2020. Review of the environmental prenatal exposome and its relationship to maternal and fetal health. Reprod Toxicol 98:1-12. doi:10.1016/j.reprotox.2020.02.004 PMID:32061676 PMCID:PMC7442624
  • Rebuli ME. 2020. Why males may have a worse response to COVID-19. (non-peer reviewed)
  • Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gershon TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah FY, Jennette JC, Kafri T, Kashfeen A, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd KK, Lutz C, Lynch RM, Magnuson T, Matsushima GK, McMullan R, Miller DR, Mohlke KL, Moy SS, Murphy C, Najarian M, O'Brien L, Palmer AA, Philpot BD, Randell SH, Reinholdt L, Ren Y, Rockwood S, Rogala AR, Saraawatula A, Sassetti CM, Schisler JC, Schoenrock SA, Shaw GD, Shorter JR, Smith CM, St Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JL, Williams L, Zylka MJ, Ferris MT, McMillan L, Pardo-Manuel de Villena F. 2020. Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research. Genetics 216:905-930. doi:10.1534/genetics.120.303596 PMID:33067325 PMCID:PMC7768238
  • Styblo M, Schmidt S. 2020. Matching rodents to people: A humanized mouse model of iAs methylation. Environ Health Perspect 128(10):104003. doi:10.1289/EHP8093 PMID:33054428 PMCID:PMC7560904
  • Venkatratnam A, Douillet C, Topping BC, Shi Q, Addo KA, Ideraabdullah FY, Fry RC, Styblo M. 2020. Sex-dependent effects of preconception exposure to arsenite on gene transcription in parental germ cells and on transcriptomic profiles and diabetic phenotype of offspring. Arch Toxicol doi:10.1007/s00204-020-02941-w PMID:33145626
  • Wang T, Wang X, George SL, Zhou H. 2020. Design and analysis of biomarker-integrated clinical trials with adaptive threshold detection and flexible patient enrichment. Journal of Biopharmaceutical Statistics 30:1060-1076. doi:10.1080/10543406.2020.1832110 PMID:33175640 PMCID:PMC7954851
  • Yu W, Hill SF, Xenakis JG, Pardo-Manuel de Villena F, Wagnon JL, Meisler MH. 2020. Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse. Epilepsia 12:2847-2856. doi:10.1111/epi.16741 PMID:33140451 PMCID:PMC7756374
  • Zavala J, Freedman AN, Szilagyi JT, Jaspers I, Wambaugh J, Higuchi M, Rager JE. 2020. New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing. Int J Environ Res Public Health 6:2124. doi:10.3390/ijerph17062124 PMID:32210027 PMCID:PMC7143849
  • Zhang J, Zhou H, Liu Y, Cai J. 2020. Feature screening for case-cohort studies with failure time outcome. Scandinavian Journal of Statistics doi:10.1111/sjos.12503 (ahead of print)
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