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Person Details

Superfund Research Program

Agnes B. Kane

Brown University
Department of Pathology and Laboratory Medicine
70 Ship Street, Box G-E5
Providence, RI 02912
Phone: 401-863-1110
Fax: 401-863-9008


Research Briefs

Hazardous Waste Sites

Mashapaug Pond

  • Brown University: Training Core



  • Kuempel E, Jaurand MC, Moller P, Morimoto Y, Kobayashi N, Pinkerton KE, Sargent LM, Vermeulen R, Fubini B, Kane AB. 2017. Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Crit Rev Toxicol 47(1):1-58. doi:10.1080/10408444.2016.1206061 PMID:27537422
  • Rodd AL, Messier N, Vaslet CA, Kane AB. 2017. A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144. doi:10.1016/j.aquatox.2017.02.018 PMID:28282620 PMCID:PMC5436724


  • Holden PA, Gardea-Torresdey JL, Klaessig F, Turco RF, Mortimer M, Hund-Rinke K, Cohen Hubal EA, Barcelo D, Avery D, Behra R, Cohen Y, Deydier-Stephan L, Ferguson PL, Fernandes TF, Herr Harthorn B, Henderson WM, Hoke RA, Hristozov D, Johnston JM, Kane AB, Kapustka L, Keller AA, Lenihan HS, Lovell W, Murphy CJ, Nisbet RM, Petersen EJ, Salinas ER, Scheringer M, Sharma M, Speed DE, Sultan Y, Westerhoff P, White JC, Wiesner MR, Wong E, Xing B, Steele Horan M, Godwin H, Nel AE. 2016. Considerations of environmentally relevant test conditions for improved evaluation of ecological hazards of engineered nanomaterials. Environ Sci Technol 50(12):6124-6145. doi:10.1021/acs.est.6b00608 PMID:27177237 PMCID:PMC4967154
  • Wang Z, von dem Bussche A, Qiu Y, Valentine TM, Gion K, Kane AB, Hurt RH. 2016. Chemical dissolution pathways of MoS2 nanosheets in biological and environmental media. Environ Sci Technol 50(13):7208-7217. doi:10.1021/acs.est.6b01881 PMID:27267956 PMCID:PMC5217159
  • Wang Z, Zhu W, Qiu Y, Yi X, von dem Bussche A, Kane AB, Gao H, Koski K, Hurt RH. 2016. Biological and environmental interactions of emerging two-dimensional nanomaterials. Chem Soc Rev 45(6):1750-1780. doi:10.1039/c5cs00914f PMID:26923057 PMCID:PMC4820079
  • Zhu WP, von dem Bussche A, Yi X, Qiu Y, Wang Z, Weston P, Hurt RH, Kane AB, Gao H. 2016. Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles. Proc Natl Acad Sci U S A 113(44):12374-12379. doi:10.1073/pnas.1605030113 PMID:27791073 PMCID:PMC5098676


  • Godwin H, Brown SS, Holden PA, Kane AB, Bergeson L, Bernard D, Beryt E, Boyes W, Clippinger A, Cohen Y, Doa M, Hendren C, Houck K, Klaessig F, Kodas T, Landsiedel R, Lynch I, Malloy T, Miller MB, Muller J, Petersen EJ, Pleus RC, Sayre P, Stone V, Sullivan KM, Tentschert J, Wallis P, Nel AE, Oberdorster G, Nameth C, Avery D. 2015. Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making. ACS Nano 9(4):3409-3417. doi:10.1021/acsnano.5b00941 PMID:25791861
  • Kabadi PK, Vantangoli MM, Rodd AL, Kane AB, Boekelheide K, Leary E, Madnick SJ, Morgan J. 2015. Into the depths: Techniques for in vitro three-dimensional microtissue visualization. Biotechniques 59(5):279-286. doi:10.2144/000114353 PMID:26554505 PMCID:PMC4804457


  • Qiu Y, Wang Z, Owens AC, Kulaots I, Chen Y, Kane AB, Hurt RH. 2014. Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology. Nanoscale 6(20):11744-11755. doi:10.1039/c4nr03275f PMID:25157875 PMCID:PMC4312421
  • Rodd AL, Creighton M, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB. 2014. Effects of surface-engineered nanoparticle-based dispersants for marine oil spills on the model organism Artemia franciscana. Environ Sci Technol 48(11):6419-6427. doi:10.1021/es500892m PMID:24823274 PMCID:PMC4046867




  • Broaddus VC, Everitt JI, Black B, Kane AB. 2011. Non-neoplastic and neoplastic pleural endpoints following fiber exposure. Journal of Toxicology and Environmental Health Part B: Critical Review 14:153-178. doi:10.1080/10937404.2011.556049 PMID:21534088 PMCID:PMC3118521 (Completed with ARRA Funds)
  • Liu X, Sen S, Liu J, Kulaots I, Geohegan D, Kane AB, Palmore TR, Hurt RH. 2011. Antioxidant deactivation on graphenic nanocarbon surfaces. Small 7(19):2775-2785. doi:10.1002/smll.201100651 PMID:21818846 PMCID:PMC3634619 (Completed with ARRA Funds)
  • Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB. 2011. Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124(1):138-148. doi:10.1093/toxsci/kfr206 PMID:21828359 PMCID:PMC3196652 (Completed with ARRA Funds)
  • Sanchez V, Weston P, Yan A, Hurt RH, Kane AB. 2011. A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials. Part Fibre Toxicol 8:17. doi:10.1186/1743-8977-8-17 PMID:21592387 PMCID:PMC3120675 (Completed with ARRA Funds)
  • Shi X, von dem Bussche A, Hurt RH, Kane AB, Gao H. 2011. Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Nat Nanotechnol 6:714-719. doi:10.1038/nnano.2011.151 PMID:21926979 PMCID:PMC3215144


  • Lau BW, Kane AB. 2010. SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids. Anticancer Res 30(6):2153-2160. PMID:20651364 PMCID:PMC3641861
  • Liu X, Hurt RH, Kane AB. 2010. Biodurability of single-walled carbon nanotubes depends on surface functionalization. Carbon N Y 48(7):1961-1969. doi:10.1016/j.carbon.2010.02.002 PMID:20352066 PMCID:PMC2844903
  • Pietruska JR, Johnston T, Zhitkovich A, Kane AB. 2010. XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole. Environ Health Perspect 118(12):1707-1713. doi:10.1289/ehp.1002312 PMID:20705543 PMCID:PMC3205592 (Completed with ARRA Funds)


  • Hoover E, Brown P, Averick M, Kane AB, Hurt RH. 2009. Teaching small and thinking large: effects of including social and ethical implications in an interdisciplinary nanotechnology course. J Nano Educ 1(1):86-95. doi:10.1166/jne.2009.013 PMID:23585917 PMCID:PMC3624993
  • Sanchez V, Pietruska JR, Miselis NR, Hurt RH, Kane AB. 2009. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1(5):511-529. doi:10.1002/wnan.41 PMID:20049814 PMCID:PMC2864601



  • Guo L, Liu XY, Sanchez V, Vaslet CA, Kane AB, Hurt RH. 2007. A window of opportunity: designing carbon nanomaterials for environmental safety and health. Material Science Forum 544-545:511-516.
  • Guo L, Morris DG, Liu X, Vaslet CA, Hurt RH, Kane AB. 2007. Iron bioavailability and redox activity in diverse carbon nanotube samples. Chemistry of Materials 19(14):3472-3478. doi:10.1021/cm062691p
  • Liu X, Gurel V, Morris D, Murray DW, Zhitkovich A, Kane AB, Hurt RH. 2007. Bioavailability of nickel in single-wall carbon nanotubes. Advanced Materials 19:2790-96.
  • Pietruska JR, Kane AB. 2007. SV40 oncoproteins enhance asbestos-induced dna double-strand breaks and abrogate senescence in murine mesothelial cells. Cancer Res 67:3637-45. PMID:17440075
  • Yan A, von dem Bussche A, Kane AB, Hurt RH. 2007. Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes. Carbon N Y 45:2463-70. PMID:19081834


  • Hurt RH, Monthioux M, Kane AB. 2006. Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue. Carbon N Y 44(6):1028-1033. doi:10.1016/j.carbon.2005.12.023
  • Yan A, Lau BW, Weissman BS, Kulaots I, Yang NY, Kane AB, Hurt RH. 2006. Biocompatible, hydrophilic, supramolecular carbon nanoparticles for cell delivery. Advanced Materials 18:2373-78. doi:10.1002/adma.200600838