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Person Details: Bevin P. Engelward

Superfund Research Program

Bevin P. Engelward

Massachusetts Institute of Technology
77 Massachusetts Avenue
16-743C
Cambridge, Massachusetts 02139
Phone: 617-258-0260
Email: bevin@mit.edu

Projects

Research Briefs

Publications

2023

  • Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, Engelward BP, Fox JG, Croy RG, Essigmann JM. 2023. Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents. NAR Cancer 5(2):doi:10.1093/narcan/zcad015 PMID:36992846 PMCID:PMC1004153
  • Collins AR, Moller P, Gajski G, Vodenkova S, Abdulwahed A, Anderson D, Bankoglu EE, Bonassi S, Boutet-Robinet E, Brunborg G, Chao C, Cooke MS, Costa C, Costa S, Dhawan A, de Lapuente J, Bo CD, Dubus J, Dusinska M, Dunthie SJ, Yamani NE, Engelward BP, Gaivao I, Giovannelli L, Godschalk RW, Guilherme S, Gutzkow KB, Habas K, Hernandez A, Herrero O, Isidori M, Jha AN, Kooter IM, Knasmuller s, Koppen G, Kruszewski M, Ladeira C, Laffon B, Larramendy M, Hegarat LL, Lewies A, Lewinska A, Liwszyc GE, Lopez de Cerain Salsamendi A, Manjanatha M, Marcos R, Milic M, de Andrade VM, Moretti M, Muruzabal D, Novak M, Oliveira R, Olsen A, Owiti NA, Pacheco M, Pandey AK, Pfuhler S, Pourrut B, Reisinger K, Rojas E, Runden-Pran E, Sanz-Serrano J, Shaposhnikov S, Sipinen V, Smeets K, Stopper H, Teixeira JP, Valdiglesias V, Valverde M, van Acker F, van Schooten F, Vasquez M, Wentzel JF, Wnuk M, Wouters A, Zegura B, Zikmund T, Langie SA, Azqueta A. 2023. Measuring DNA modifications with the comet assay: a compendium of protocols. Nat Protoc doi:10.1038/s41596-022-00754-y PMID:36707722 PMCID:PMC10281087

2022

  • Buick JK, Rowan-Carroll A, Gagne R, Williams A, Chen R, Li H, Fornace AJ, Chao C, Engelward BP, Frotschl R, Ellinger-Ziegelbauer H, Pettit S, Aubrecht J, Yauk C. 2022. Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip assay in TK6 cells. Front Toxicol 4:991590. doi:10.3389/ftox.2022.991590 PMID:36211197 PMCID:PMC9540394
  • Hrdina AI, Kohale I, Kaushal S, Kelly J, Selin NE, Engelward BP, Kroll JH. 2022. The parallel transformations of polycyclic aromatic hydrocarbons in the body and in the atmosphere. Environ Health Perspect 130(2):doi:10.1289/EHP9984 PMID:35225689 PMCID:PMC8884122
  • Moise AC, Kay JE, Engelward BP. 2022. Transgenic mice harboring direct repeat substrates reveal key underlying causes of homologous recombination in vivo. DNA Repair (Amst) 120:103419. doi:10.1016/j.dnarep.2022.103419 PMID:36257175
  • Owiti NA, Corrigan JJ, Pribyl LJ, Kay J, Engelward BP. 2022. Novel in vivo CometChip reveals NDMA-induced DNA damage and repair in multiple mouse tissues. Int J Mol Sci 23(19):11776. doi:10.3390/ijms231911776 PMID:36233095 PMCID:PMC9569458
  • Owiti NA, Kaushal S, Martin L, Sly J, Swartz CD, Fowler J, Corrigan JJ, Recio L, Engelward BP. 2022. Using the HepaCometChip assay for broad-spectrum DNA damage analysis. Curr Protoc 2(9):e563. doi:10.1002/cpz1.563 PMID:36165707 PMCID:PMC9522315
  • Pradhan D, Ding H, Zhu J, Engelward BP, Levine SS. 2022. NExtSEEK: Extending SEEK for active management of interoperable metadata. J Biomol Tech 33(1):doi:10.7171/3fc1f5fe.db404124 PMID:35836998 PMCID:PMC9258913

2021

  • Buick JK, Williams A, Meier MJ, Swartz C, Recio L, Gagne R, Ferguson SS, Engelward BP, Yauk C. 2021. A modern genotoxicity testing paradigm: Integration of the high-throughput CometChip and the TGx-DDI transcriptomic biomarker in human HepaRG cell cultures. Front Public Health 9:doi:10.3389/fpubh.2021.694834 PMID:34485225 PMCID:PMC8416458
  • Engelward BP. 2021. Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer. Environ Mol Mutagen 62:288-292. doi:10.1002/em.22434 PMID:33963777
  • Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay J, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. 2021. CometChip enables parallel analysis of multiple DNA repair activities. DNA Repair (Amst) 106(11):doi:10.1016/j.dnarep.2021.103176 PMID:34365116 PMCID:PMC8439179
  • Kay J, Corrigan JJ, Armijo AL, Nazari IS, Kohale I, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. 2021. Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice. Cell Rep 34(11):108864. doi:10.1016/j.celrep.2021.108864 PMID:33730582
  • Kelly JM, Ivatt PD, Evans MJ, Kroll JH, Hrdina AI, Kohale I, White FM, Engelward BP, Selin NE. 2021. Global cancer risk from unregulated polycyclic aromatic hydrocarbons. Geohealth 5(9):doi:10.1029/2021GH000401 PMID:34589640 PMCID:PMC8460132
  • Owiti NA, Nagel Z, Engelward BP. 2021. Fluorescence sheds light on DNA damage, DNA repair, and mutations. Trends Cancer 7(3):240-248. doi:10.1016/j.trecan.2020.10.006 PMID:33203608 PMCID:PMC7889721

2020

2019

2004

  • Ham AL, Engelward BP, Koc H, Sangaiah R, Meira LB, Samson LD, Swenberg JA. 2004. New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N-6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. DNA Repair (Amst) 3(3):257-265. PMID:15177041
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