Superfund Research Program
Peter S. Thorne
University of Iowa
Department of Occupational & Environmental Health
College of Public Health
Iowa City, Iowa 52242
Phone: 319-335-4216
Email: peter-thorne@uiowa.edu
Projects
- University of Iowa: Assessment of Toxicity and Risk of Inhaled Environmental PCB Mixtures (2015-2020)
- University of Iowa: Inhalation Toxicology Core (2006 - 2015)
- University of Iowa: Research Translation Core (2006-2020)
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants (2006-2025)
Research Briefs
Hazardous Waste Sites
East Chicago City Dump
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
Energy Cooperative Incorporated
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
Indiana Pallet
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
Kerr-Mcgee (Reed-Keppler Park)
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
Kerr-Mcgee (Residential Areas)
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
Kerr-Mcgee (Sewage Treatment Plant)
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
NGPCA - LETTS - 199
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
U.S. Smelter and Lead Refinery, Inc.
- University of Iowa: The AESOP Study: Airborne Exposures to Semi-volatile Organic Pollutants
Publications
2024
- Bullert AJ, Li X, Gautam B, Wang H, Adamcakova-Dodd A, Wang K, Thorne PS, Lehmler H. 2024. Distribution of 2,2',5,5'-tetrachlorobiphenyl (PCB52) metabolites in adolescent rats after acute nose-only inhalation exposure. Environ Sci Technol 58(14):6105-6116. doi:10.1021/acs.est.3c09527 PMID:38547313 PMCID:11008251
2023
- Lan T, Liu B, Bao W, Thorne PS. 2023. Identification of PCB congeners and their thresholds associated with diabetes using decision tree analysis. Sci Rep 13(1):18322. doi:10.1038/s41598-023-45301-1 PMID:37884570 PMCID:PMC10603165
- Wang H, Bullert AJ, Li X, Stevens HE, Klingelhutz AJ, Ankrum J, Adamcakova-Dodd A, Thorne PS, Lehmler H. 2023. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 500:153677. doi:10.1016/j.tox.2023.153677 PMID:37995827 PMCID:PMC10757425
2022
- Haque E, Jing X, Bostick BC, Thorne PS. 2022. In vitro and in silico bioaccessibility of urban dusts contaminated by multiple legacy sources of lead (Pb). J Hazard Mater 8:100178. doi:10.1016/j.hazadv.2022.100178
- Haque E, Moran ME, Wang H, Adamcakova-Dodd A, Thorne PS. 2022. Validation of blood arsenic and manganese assessment from archived clotted erythrocyte fraction in an urban cohort of mother-child dyads. Sci Total Environ 810:doi:10.1016/j.scitotenv.2021.152320 PMID:34915002
- Martinez A, Hua J, Haque E, Hornbuckle KC, Thorne PS. 2022. Occurrence and spatial distribution of individual polychlorinated biphenyl congeners in residential soils from East Chicago, southwest Lake Michigan. Sci Total Environ 850:157705. doi:10.1016/j.scitotenv.2022.157705 PMID:35931157
- Wang H, Adamcakova-Dodd A, Lehmler H, Hornbuckle KC, Thorne PS. 2022. Toxicity assessment of 91-day repeated inhalation exposure to an indoor school air mixture of PCBs. Environ Sci Technol doi:10.1021/acs.est.1c05084 PMID:34994547
- Zhang D, Saktrakulkla P, Marek RF, Lehmler H, Wang K, Thorne PS, Hornbuckle KC, Duffel MW. 2022. PCB sulfates in serum from mothers and children in urban and rural US communities. Environ Sci Technol doi:10.1021/acs.est.2c00223 PMID:35500099 PMCID:PMC9118556
2021
- Haque E, Moran ME, Thorne PS. 2021. Retrospective blood lead assessment from archived clotted erythrocyte fraction in a cohort of lead-exposed mother-child dyads. Sci Total Environ 754:142166. doi:10.1016/j.scitotenv.2020.142166 PMID:32920407 PMCID:PMC7686297
- Haque E, Thorne PS, Nghiem AA, Yip CS, Bostick BC. 2021. Lead (Pb) concentrations and speciation in residential soils from an urban community impacted by multiple legacy sources. J Hazard Mater 416:125886. doi:10.1016/j.jhazmat.2021.125886 PMID:34492824 PMCID:PMC8666965
- Haque E, Thorne PS, Nghiem AA, Yip CS, Bostick BC. 2021. Lead (Pb) concentrations and speciation in residential soils from an urban community impacted by multiple legacy sources. J Hazard Mater 416:
- Lan T, Liu B, Bao W, Thorne PS. 2021. BMI modifies the association between dietary intake and serum levels of PCBs. Environ Int 156:106626. doi:10.1016/j.envint.2021.106626 PMID:34034117
2020
- Saktrakulkla P, Lan T, Hua J, Marek RF, Thorne PS, Hornbuckle KC. 2020. Polychlorinated biphenyls in food. Environ Sci Technol 54:11443-11452. doi:10.1021/acs.est.0c03632 PMID:32816464 PMCID:PMC7759298
- Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
2017
- Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
- Marek RF, Thorne PS, Herkert N, Awad AM, Hornbuckle KC. 2017. Airborne PCBs and OH-PCBs inside and outside urban and rural U.S. schools. Environ Sci Technol 51(14):7853-7860. doi:10.1021/acs.est.7b01910 PMID:28656752 PMCID:PMC5777175
2016
- Koh W, Hornbuckle KC, Wang K, Thorne PS. 2016. Serum polychlorinated biphenyls and their hydroxylated metabolites are associated with demographic and behavioral factors in children and mothers. Environ Int 94:538-545. doi:10.1016/j.envint.2016.06.014 PMID:27352881 PMCID:PMC4980156
- Koh WX, Hornbuckle KC, Marek RF, Wang K, Thorne PS. 2016. Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two US Midwestern communities. Chemosphere 147:389-395. doi:10.1016/j.chemosphere.2015.12.113 PMID:26774304 PMCID:PMC4747419
- Wangpradit O, Adamcakova-Dodd A, Heitz K, Robertson LW, Thorne PS, Luthe G. 2016. PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats. Environ Sci Pollut Res Int 23(3):2128-2137. doi:10.1007/s11356-015-5022-5 PMID:26400242 PMCID:PMC4803647
2015
- Ampleman MD, Martinez A, DeWall J, Rawn DF, Hornbuckle KC, Thorne PS. 2015. Inhalation and dietary exposure to PCBs in urban and rural cohorts via congener-specific measurements. Environ Sci Technol 49(2):1156-1164. doi:10.1021/es5048039 PMID:25510359 PMCID:PMC4303332
- Hu X, Adamcakova-Dodd A, Lehmler H, Gibson-Corley KN, Thorne PS. 2015. Toxicity evaluation of exposure to an atmospheric mixture of polychlorinated biphenyls by nose-only and whole-body inhalation regimens. Environ Sci Technol 49(19):11875-11883. doi:10.1021/acs.est.5b02865 PMID:26348937 PMCID:PMC4711378
- Jones MP, Perry SS, Thorne PS. 2015. Maximum pairwise psuedo-likelihood estimation of the covariance matrix from left-censored data. J Agric Biol Environ Stat 20(1):83-99. doi:10.1007/s13253-014-0185-y
- Koh WX, Hornbuckle KC, Thorne PS. 2015. Human serum from urban and rural adolescents and their mothers shows exposure to polychlorinated biphenyls not found in commercial mixtures. Environ Sci Technol 49(13):8105-8112. doi:10.1021/acs.est.5b01854 PMID:26053216 PMCID:PMC4774248
2014
- Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150h PMID:24988477 PMCID:PMC4137987
- Hu X, Adamcakova-Dodd A, Thorne PS. 2014. The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environ Int 63:92-100. doi:10.1016/j.envint.2013.10.017 PMID:24275706 PMCID:PMC3950335
- Kim J, Klosener J, Flor S, Peters TM, Ludewig G, Thorne PS, Robertson LW, Luthe G. 2014. Toxicity assessment of air-delivered particle-bound polybrominated diphenyl ethers. Toxicology 317:31-39. doi:10.1016/j.tox.2014.01.005 PMID:24451063 PMCID:PMC3975599
- Marek RF, Thorne PS, DeWall J, Hornbuckle KC. 2014. Variability in PCB and OH-PCB serum levels in children and their mothers in urban and rural US communities. Environ Sci Technol 48(22):13459-13467. doi:10.1021/es502490w PMID:25300024 PMCID:PMC4238695
2013
- Dhakal K, Adamcakova-Dodd A, Lehmler H, Thorne PS, Robertson LW. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chem Res Toxicol 26(6):853-855. doi:10.1021/tx4001539 PMID:23713983 PMCID:PMC3703249
- Hu X, Lehmler H, Adamcakova-Dodd A, Thorne PS. 2013. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite. Environ Sci Technol 47(9):4743-4751. doi:10.1021/es3049114 PMID:23582014 PMCID:PMC3962796
- Marek RF, Thorne PS, Wang K, DeWall J, Hornbuckle KC. 2013. PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities. Environ Sci Technol 47(7):3353-3361. doi:10.1021/es304455k PMID:23452180 PMCID:PMC3645264
2012
- Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Hornbuckle KC, Thorne PS. 2012. Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile. Environ Sci Technol 46(17):9653-9662. doi:10.1021/es301129h PMID:22846166 PMCID:PMC3573703
2010
- Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Kania-Korwel I, Hornbuckle KC, Thorne PS. 2010. Time course of congener uptake and elimination in rats after short-term inhalation exposure to an airborne polychlorinated biphenyl (PCB) mixture. Environ Sci Technol 44(17):6893-6900. doi:10.1021/es101274b PMID:20698547 PMCID:PMC3408216
- Norstrom K, Czub G, McLachlan MS, Hu D, Thorne PS, Hornbuckle KC. 2010. External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment. Environ Int 36(8):855-861. doi:10.1016/j.envint.2009.03.005 PMID:19394084 PMCID:PMC2891214
- Zhao H, Adamcakova-Dodd A, Hu D, Hornbuckle KC, Just CL, Robertson LW, Thorne PS, Lehmler H. 2010. Development of a synthetic PCB mixture resembling the average polychlorinated biphenyl profile in Chicago air. Environ Int 36(8):819-827. doi:10.1016/j.envint.2009.03.003 PMID:19375801 PMCID:PMC2888912
2009
- Klosener J, Peters TM, Adamcakova-Dodd A, Teesch LM, Thorne PS, Robertson LW, Luthe G. 2009. Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures. Chem Res Toxicol 22(1):179-186. doi:10.1021/tx8003032 PMID:19111055 PMCID:PMC3120107
2007
- Norstrom K, Czub B, McLachlan M, Thorne PS, Hornbuckle KC. 2007. Serum PCBs in five men from Chicago: consideration of current exposures. Discernment of dietary and inhalation exposure to PCBs from congener profiles in blood. Chapter 47(2)in: American Chemical Society Division of Environmental Chemistry Annual Meefing. Boston, MA. pp.433-436.