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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Dr. Philippe Grandjean

Superfund Research Program

Dr. Philippe Grandjean

University of Rhode Island
Avedisian Hall
7 Greenhouse Road
Kingston, Rhode Island 02881
Phone: 617-432-1260
Fax: 617-432-3441
Email: pgrand@uri.edu

Projects

Research Briefs

Publications

2024

  • Andersen HR, Grandjean P, Main K, Jensen TK, Nielsen F. 2024. Higher serum concentrations of PFAS among pesticide exposed female greenhouse workers. Int J Hyg Environ Health 255:doi:10.1016/j.ijheh.2023.114292 PMID:37952389
  • Nielsen F, Fischer FC, Leth P, Grandjean P. 2024. Occurrence of major perfluorinated alkylate substances in human blood and target organs. Environ Sci Technol 58(1):143-149. doi:10.1021/acs.est.3c06499 PMID:38154793 PMCID:10785751
  • Sigvaldsen A, Højsager F, Paarup H, Beck I, Timmermann CA, Boye H, Nielsen F, Halldorsson T, Nielsen C, Möller S, Barington T, Grandjean P, Jensen TK. 2024. Early-life exposure to perfluoroalkyl substances and serum antibody concentrations towards common childhood vaccines in 18-month-old children in the Odense Child Cohort. Environ Res 242:117814. doi:10.1016/j.envres.2023.117814 PMID:38042520

2023

  • Baumert BO, Fischer FC, Nielsen F, Grandjean P, Bartell SM, Stratakis N, Walker DI, Valvi D, Kohli R, Inge T, Ryder J, Jenkins T, Sisley S, Xanthakos S, Rock S, La Merrill MA, Conti D, McConnell R, Chatzi L. 2023. Paired liver:plasma PFAS concentration ratios from adolescents in the Teen-LABS Study and derivation of empirical and mass balance models to predict and explain liver PFAS accumulation. Environ Sci Technol 57(40):14817-14826. doi:10.1021/acs.est.3c02765 PMID:37756184 PMCID:PMC10591710
  • Grandjean P, Meddis A, Nielsen F, Beck IH, Bilenberg N, Goodman C, Hu H, Till C, Budtz-Jorgensen E. 2023. Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies. Eur J Public Health doi:10.1093/eurpub/ckad170 PMID:37798092
  • Grandjean P, Meddis A, Nielsen F, Sjodin A, Hjorth MF, Astrup A, Budtz-Jorgensen E. 2023. Weight loss relapse associated with exposure to perfluoroalkylate substances. Obesity (Silver Spring) doi:10.1002/oby.23755 PMID:37069729 PMCID:PMC5810983
  • Valvi D, Christiani DC, Coull BA, Hojlund K, Nielsen F, Audouze K, Su L, Grandjean P. 2023. Gene-environment interactions in the associations of PFAS exposure with insulin sensitivity and beta-cell function in a Faroese cohort followed from birth to adulthood. Environ Res 226:115600. doi:10.1016/j.envres.2023.115600 PMID:36868448 PMCID:PMC1010192

2022

  • Blomberg AJ, Mortensen J, Weihe P, Grandjean P. 2022. Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study. Environmental Health 21(1):113. doi:10.1186/s12940-022-00929-w PMID:36402982 PMCID:PMC9675242
  • Lochhead P, Khalili H, Ananthakrishnan AN, Burke KE, Richter JM, Sun Q, Grandjean P, Chan AT. 2022. Plasma concentrations of perfluoroalkyl substances and risk of inflammatory bowel diseases in women: a nested case control analysis in the Nurses' Health Study cohorts. Environ Res 207:112222. doi:10.1016/j.envres.2021.112222 PMID:34662575

2021

  • Birukov A, Andersen LB, Andersen M, Nielsen JH, Nielsen F, Kyhl HB, Jorgensen JS, Grandjean P, Dechend R, Jensen TK. 2021. Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort. Environ Int 151:106442. doi:10.1016/j.envint.2021.106442 PMID:33610053
  • Blomberg AJ, Shih Y, Messerlian C, Jorgensen LH, Weihe P, Grandjean P. 2021. Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort. Environ Res 200:111400. doi:10.1016/j.envres.2021.111400 PMID:34081971 PMCID:PMC8403652
  • Dalsager L, Christensen N, Halekoh U, Timmermann CA, Nielsen F, Kyhl HB, Husby S, Grandjean P, Jensen TK, Andersen HR. 2021. Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort. Environ Int 149:106395. doi:10.1016/j.envint.2021.106395 PMID:33508532
  • Dalsager L, Jensen TK, Nielsen F, Grandjean P, Bilenberg N, Andersen HR. 2021. No association between maternal and child PFAS concentrations and repeated measures of ADHD symptoms at age 21/2 and 5 years in children from the Odense Child Cohort. Neurotoxicol Teratol 88:PMID:34563660
  • Etzel RA, Grandjean P, Ozonoff DM. 2021. Environmental epidemiology in a crossfire. Environmental Health 20(1):91. doi:10.1186/s12940-021-00776-1 PMID:34412648 PMCID:PMC8375458
  • Gardener H, Sun Q, Grandjean P. 2021. PFAS concentration during pregnancy in relation to cardiometabolic health and birth outcomes. Environ Res 192:110287. doi:10.1016/j.envres.2020.110287 PMID:33038367 PMCID:PMC7736328
  • Shih Y, Blomberg AJ, Bind M, Holm D, Nielsen F, Heilmann C, Weihe P, Grandjean P. 2021. Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands. J Immunotoxicol 18(1):85-92. PMID:34143710 (ahead of print)
  • Shih Y, Blomberg AJ, Jorgensen LH, Weihe P, Grandjean P. 2021. Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort. Environ Res 204(7):111905. doi:10.1016/j.envres.2021.111905 PMID:34419464
  • Valvi D, Hojlund K, Coull BA, Nielsen F, Weihe P, Grandjean P. 2021. Life-course exposure to perfluoroalkyl substances in relation to markers of glucose homeostasis in early adulthood. J Clin Endocrinol Metab 106(8):2495-2504. doi:10.1210/clinem/dgab267 PMID:33890111 PMCID:PMC8277200
  • Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K. 2021. Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach. Environ Int 157:doi:10.1016/j.envint.2020.106232 PMID:33223326 PMCID:PMC7831776

2020

  • Grandjean P, Timmermann CA, Kruse M, Nielsen F, Vinholt PJ, Boding L, Heilmann C, Molbak K. 2020. Severity of COVID-19 at elevated exposure to perfluorinated alkylates. PLoS One 15:doi:10.1371/journal.pone.0244815 PMID:33382826
  • Jensen RC, Andersen M, Larsen PV, Glintborg D, Dalgard C, Timmermann CA, Nielsen F, Sandberg MB, Andersen HR, Christesen HT, Grandjean P, Jensen TK. 2020. Prenatal exposures to perfluoroalkyl acids and associations with markers of adiposity and plasma lipids in infancy: An Odense Child Cohort study. Environ Health Perspect 128(7):77001. doi:10.1289/EHP5184 PMID:32628516 PMCID:PMC7338787
  • Landrigan PJ, Stegeman JJ, Fleming LE, Allemand D, Anderson DM, Backer L, Brucker-Davis F, Chevalier N, Corra L, Czerucka D, Bottein MD, Demeneix B, Depledge MH, Deheyn DD, Dorman CJ, Fenichel P, Fisher S, Gaill F, Galgani F, Gaze WH, Giuliano L, Grandjean P, Hahn ME, Hamdoun A, Hess P, Judson B, Laborde A, McGlade J, Mu J, Mustapha A, Neira M, Noble RT, Pedrotti ML, Reddy C, Rocklov J, Scharler UM, Shanmugam H, Taghian G, van de Water JA, Vezzulli L, Weihe P, Zeka A, Raps H, Rampal P. 2020. Human health and ocean pollution. Ann Glob Health 86:64. doi:10.5334/aogh.2831 PMID:33354517 PMCID:PMC7731724
  • Liu G, Zhang B, Hu Y, Rood J, Liang L, Qi L, Bray GA, DeJonge L, Coull BA, Grandjean P, Furtado JD, Sun Q. 2020. Associations of perfluoroalkyl substances with blood lipids and apolipoproteins in lipoprotein subspecies: The POUNDS-lost study. Environmental Health 19:doi:10.1186/s12940-020-0561-8 PMID:31931806 PMCID:PMC6958662
  • Timmermann CA, Jensen KJ, Nielsen F, Budtz-Jorgensen E, van der Klis F, Benn CS, Grandjean P, Fisker AB. 2020. Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children. Environ Health Perspect 128:doi:10.1289/ehp6517 PMID:32772733 PMCID:PMC7416537
  • Waterfield G, Rogers M, Grandjean P, Auffhammer M, Sunding D. 2020. Reducing exposure to high levels of perfluorinated compounds in drinking water improves reproductive outcomes: Evidence from an intervention in Minnesota. Environ Health 19(1):42. doi:10.1186/s12940-020-00591-0 PMID:32321520 PMCID:PMC7178962

2019

  • Ammitzboll C, Bornsen L, Petersen ER, Oturai AB, Sondergaard HB, Grandjean P, Sellebjerg F. 2019. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation. J Neuroimmunol 330:90-95. doi:10.1016/j.jneuroim.2019.03.002 PMID:30852181 PMCID:PMC6461219
  • Eryasa B, Grandjean P, Nielsen F, Valvi D, Zmirou-Navier D, Sunderland EM, Weihe P, Oulhote Y. 2019. Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances. Environ Int 130:doi:10.1016/j.envint.2019.05.068 PMID:31200157 PMCID:PMC7029428
  • Grandjean P. 2019. Developmental fluoride neurotoxicity: An updated review. Environmental Health 18:doi:10.1186/s12940-019-0551-x PMID:31856837 PMCID:PMC6923889
  • Grandjean P, Abdennebi-Najar L, Barouki R, Cranor CF, Etzel RA, Gee D, Heindel J, Hougaard KS, Hunt P, Nawrot T, Prins GS, Ritz B, Soffritti M, Sunyer J, Weihe P. 2019. Timescales of developmental toxicity impacting on research and needs for intervention. Basic Clin Pharmacol Toxicol 125:70-80. doi:10.1111/bcpt.13162 PMID:30387920 PMCID:PMC6497561
  • Hu XC, Tokranov AK, Liddie J, Zhang X, Grandjean P, Hart JE, Laden F, Sun Q, Yeung LW, Sunderland EM. 2019. Tap water contributions to plasma concentrations of poly- and perfluoroalkyl substances (PFAS) in a nationwide prospective cohort of U.S. women. Environ Health Perspect doi:10.1289/EHP4093 PMID:31170009 PMCID:PMC6792361
  • Shaffer RM, Sellers SP, Baker MG, de Buen Kalman R, Frostad J, Suter MK, Anenberg SC, Balbus J, Basu N, Bellinger DC, Birnbaum LS, Brauer M, Cohen A, Ebi KL, Fuller R, Grandjean P, Hess JJ, Kogevinas M, Kumar P, Landrigan PJ, Lanphear BP, London SJ, Rooney AA, Stanaway JD, Trasande L, Walker K, Hu H. 2019. Improving and expanding estimates of the global burden of disease due to environmental health risk factors. Environ Health Perspect 127:doi:10.1289/EHP5496 PMID:31626566 PMCID:PMC6867191
  • Shelly C, Grandjean P, Oulhote Y, Plomgaard P, Frikke-Schmidt R, Nielsen F, Zmirou-Navier D, Weihe P, Valvi D. 2019. Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood. J Clin Endocrinol Metab 104(11):5338-48. doi:10.1210/jc.2019-00385 PMID:31216000 PMCID:PMC6773461 (ahead of print)
  • Xiao C, Grandjean P, Valvi D, Nielson F, Jensen TK, Weihe P, Oulhote Y. 2019. Associations of Exposure to Perfluoroalkyl Substances With Thyroid Hormone Concentrations and Birth Size. J Clin Endocrinol Metab 105:doi:10.1210/clinem/dgz147

2018

2016

  • Lindstrom AB, Bruton TA, Schaider LA, Grandjean P, Carignan C, Blum A, Higgins CP, Sunderland EM, Hu XC, Andrews DQ, Lohmann R, Balan SA. 2016. Detection of poly- and perfluoroalkyl substances (PFASs) in US drinking water linked to industrial sites, military fire training areas, and wastewater treatment plants. Environ Sci Technol Lett 3(10):344-350. doi:10.1021/acs.estlett.6b00260 PMID:27752509 PMCID:PMC5062567
  • Sunderland EM, Driscoll CT, Hammitt JK, Grandjean P, Evans J, Blum JD, Chen CY, Evers DC, Jaffe D, Mason RP, Goho S, Jacobs W. 2016. Benefits of regulating hazardous air pollutants from coal and oil-fired utilities in the United States. Environ Sci Technol 50(5):2117-2120. doi:10.1021/acs.est.6b00239 PMID:26848613

2015

  • Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel R, Gray K, Ha E, Junien C, Karagas MR, Kawamoto T, Lawrence BP, Perera F, Prins GS, Rosenfeld CS, Sherr DH, Sly PD, Suk WA, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ. 2015. Life-long implications of developmental exposure to environmental stressors: new perspectives. Endocrinology 156(10):3408-3415. doi:10.1210/EN.2015-1350 PMID:26241067 PMCID:PMC4588822
  • Heindel JJ, Balbus J, Birnbaum LS, Brune-Drisse MN, Grandjean P, Gray K, Landrigan PJ, Sly PD, Suk WA, Cory-Slechta DA, Thompson CL, Hanson M. 2015. Developmental origins of health and disease: integrating environmental influences. Endocrinology 156(10):3416-3421. doi:10.1210/EN.2015-1394 PMID:26241070 PMCID:PMC4588819
  • Pearce N, Blair AE, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli A, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, Mannetje A, McMichael AJ, McLaughlin J, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer F, Monson RR, Nordby K, Olshan A, Parent M, Perera F, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart P, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger DD, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123(6):507-514. doi:10.1289/ehp.1409149 PMID:25712798 PMCID:PMC4455595

2012

  • Karagas MR, Choi AL, Oken E, Horvat M, Schoeny R, Kamai E, Cowell W, Grandjean P, Korrick SA. 2012. Evidence on the human health effects of low-level methylmercury exposure. Environ Health Perspect 120:799-806. doi:10.1289/ehp.1104494 PMID:22275730 PMCID:PMC3385440

2006

2003

  • Longnecker MP, Wolff MS, Gladen BC, Brock JW, Grandjean P, Jacobson JL, Korrick SA, Rogan WJ, Weisglass-Kuperus N, Hertz-Picciotto I, Ayotte P, Stewart P, Winneke G, Charles MJ, Jacobson SW, Dewailly E, Boersma E, Altshul LM, Heinzow B, Pagano JJ, Jensen AA. 2003. Comparison of polychlorinated biphenyl (PCB) levels across studies of human neurodevelopment. Environ Health Perspect 111(1):65-70. PMID:12515680

2000

  • Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB. 2000. Organochlorine exposure and breast cancer (in Danish). Ugeskr Laeger 162:922-926.
  • Hoyer AP, Jorgensen T, Brock JW, Grandjean P. 2000. Organochlorine exposure and breast cancer survival. J Clin Epidemiol 53(3):323-330. PMID:10760644

1998

  • Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB. 1998. Organochlorine exposure and risk of breast cancer. Lancet 352(9143):1816-1820. PMID:9851382
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