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Person Details: Tammy R. Dugas

Superfund Research Program

Tammy R. Dugas

Louisiana State University
School of Veterinary Medicine
Dept. of Comparative Biomedical Sciences
Skip Bertman Drive
Baton Rouge, Louisiana 70803
Phone: 225-578-7581


Research Briefs



  • Aryal A, Harmon AC, Varner K, Noël A, Cormier SA, Nde D, Mottram P, Maxie J, Dugas TR. 2024. Inhalation of particulate matter containing environmentally persistent free radicals induces endothelial dysfunction mediated via AhR activation at the air-blood interface. Toxicol Sci doi:10.1093/toxsci/kfae007 PMID:38310335


  • Aryal A, Noel A, Khachatryan L, Cormier SA, Chowdhury PH, Penn A, Dugas TR, Harmon AC. 2023. Environmentally persistent free radicals: Methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences. Environ Pollut 334:122183. doi:10.1016/j.envpol.2023.122183 PMID:37442324
  • Noël A, Harmon AC, Subramanian B, Perveen Z, Aryal A, Legendre K, Zaman H, Paulsen DB, Varner KJ, Dugas TR, Penn A. 2023. Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice. Inhal Toxicol 35:333-349. doi:10.1080/08958378.2023.2289024 PMID:38060410 PMCID:10903547


  • Aryal A, Harmon AC, Dugas TR. 2021. Particulate matter air pollutants and cardiovascular disease: Strategies for intervention. Pharmacol Ther 223:107890. doi:10.1016/j.pharmthera.2021.107890 PMID:33992684 PMCID:PMC8216045
  • Harmon AC, Noel A, Subramanian B, Perveen Z, Jennings MH, Chen Y, Penn A, Legendre K, Paulsen DB, Varner KJ, Dugas TR. 2021. Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function. Am J Physiol Heart Circ Physiol 321(4):H667-H683. doi:10.1152/ajpheart.00725.2020 PMID:34415187



  • Dugas TR. 2018. Unraveling mechanisms of toxicant-induced oxidative stress in cardiovascular disease. Curr Opin Toxicol 7:1-8. doi:10.1016/j.cotox.2017.10.007 PMID:29423456 PMCID:PMC5798618
  • Harmon AC, Hebert VY, Cormier SA, Subramanian B, Reed JR, Backes WL, Dugas TR. 2018. Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells. PLoS One 13:18. doi:10.1371/journal.pone.0205412 PMID:30308017 PMCID:PMC6181347
  • Jaligama S, Patel VS, Wang P, Sallam AA, Harding JN, Kelley MA, Mancuso SR, Dugas TR, Cormier SA. 2018. Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor. Part Fibre Toxicol 15:20. doi:10.1186/s12989-018-0255-3 PMID:29724254


  • Dugas TR, Lomnicki S, Cormier SA, Dellinger B, Reams MA. 2016. Addressing emerging risks: scientific and regulatory challenges associated with environmentally persistent free radicals. Int J Environ Res Public Health 13(6):573. doi:10.3390/ijerph13060573 PMID:27338429 PMCID:PMC4924030


  • Jaligama S, Chen Z, Saravia J, Yadav N, Lomnicki S, Dugas TR, Cormier SA. 2015. Exposure to deepwater horizon crude oil burnoff particulate matter induces pulmonary inflammation and alters adaptive immune response. Environ Sci Technol 49(14):8769-8776. doi:10.1021/acs.est.5b01439 PMID:26115348 PMCID:PMC4526136


  • Lee GI, Saravia J, You D, Shrestha B, Jaligama S, Hebert VY, Dugas TR, Cormier SA. 2014. Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection. Part Fibre Toxicol 11:57. doi:10.1186/s12989-014-0057-1 PMID:25358535 PMCID:PMC4222384
  • Lomnicki S, Gullett BK, Stoger T, Kennedy I, Diaz J, Dugas TR, Varner KJ, Carlin DJ, Dellinger B, Cormier SA. 2014. Combustion by-products and their health effects--combustion engineering and global health in the 21st century: issues and challenges. Int J Toxicol 33(1):3-13. doi:10.1177/1091581813519686 PMID:24434722 PMCID:PMC3944372


  • Kelley MA, Hebert VY, Thibeaux TM, Orchard MA, Hasan F, Cormier SA, Thevenot PT, Lomnicki S, Varner KJ, Dellinger B, Latimer BM, Dugas TR. 2013. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol 26(12):1862-1871. doi:10.1021/tx400227s PMID:24224526 PMCID:PMC4112599
  • Thevenot PT, Saravia J, Giaimo JD, Happel KI, Dugas TR, Cormier SA. 2013. Chronic alcohol induces M2 polarization enhancing pulmonary disease caused by exposure to particulate air pollution. Alcohol Clin Exp Res 37(11):1910-1919. doi:10.1111/acer.12184 PMID:23763452 PMCID:PMC3775861
  • Thevenot PT, Saravia J, Jin N, Giaimo JD, Chustz RE, Mahne S, Kelley MA, Hebert VY, Dellinger B, Dugas TR, DeMayo FJ, Cormier SA. 2013. Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells. Am J Respir Cell Mol Biol 48(2):188-197. doi:10.1165/rcmb.2012-0052OC PMID:23087054 PMCID:PMC3604062


  • Lord K, Moll D, Lindsey JK, Mahne S, Raman G, Dugas TR, Cormier SA, Troxlair D, Lomnicki S, Dellinger B, Varner KJ. 2011. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo. J Recept Signal Transduct Res 31(2):157-167. doi:10.3109/10799893.2011.555767 PMID:21385100 PMCID:PMC3152960 (Completed with ARRA Funds)
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