Superfund Research Program

Quan Lu

Harvard School of Public Health
Bldg 1
665 Huntington Ave
Boston, Massachusetts 02115
Phone: 617-432-7145
Fax: 617-432-4710
Email: qlu@hsph.harvard.edu

Projects

• Harvard School of Public Health: Administrative Core (2020-2025)
• Harvard School of Public Health: EV miRs in Cognitive Function Decline Associated with Early-Life Metal Exposure (2020-2025)
• Harvard School of Public Health: Genetic Mechanisms of Metal Neurotoxicity (2010-2015)

Research Briefs

• 346 - Mechanism of Cadmium-induced Neurotoxicity, Potential Treatment Revealed
• 208 - A Flurry of Arsenic Findings

Patents

• ARRDC1-mediated microvesicles (ARMMS) and Uses Thereof
• Methods and compositions for inhibition of beta2-adrenergic receptor degradation
• Unbiased genome-wide RNAi library derived from expressed sequence tags
• WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES
• WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES TARGETING CORONAVIRUSES
• WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES TARGETING HIV

Publications

2023

• Chen Z, Qiao Z, Wirth CR, Park H, Lu Q. 2023. Arrestin domain-containing protein 1-mediated microvesicles (ARMMs) protect against cadmium-induced neurotoxicity. Extracell Vesicle 2:100027. doi:10.1016/j.vesic.2023.100027 PMID:37614814 PMCID:PMC10443948
• Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang S, Lu Q. 2023. Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles. Sci Adv 9(4):eade2708. doi:10.1126/sciadv.ade2708 PMID:36706192 PMCID:PMC9882979
• Park H, Azzara D, Cohen ED, Boomhower S, Diwadkar AR, Himes BE, O'Reilly MA, Lu Q. 2023. Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells. J Hazard Mater 463:132906. doi:10.1016/j.jhazmat.2023.132906 PMID:37939567

2018

• Sun R, Wang Z, Henn BC, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile ML, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. 2018. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry PMID:30120420

2017

• Wagner PJ, Park H, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. 2017. In vitro effects of lead on gene expression in neural stem cells and associations between up-regulated genes and cognitive scores in children. Environ Health Perspect 125(4):721-729. doi:10.1289/ehp265 PMID:27562236
• Wang Z, Henn BC, Wang C, Wei Y, Li S, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright RO, Bellinger DC, Kile ML, Mazumdar M, Tellez-Rojo M, Schnaas L, Christiani DC. 2017. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health 16:81. doi:10.1186/s12940-017-0288-3 PMID:28754176 PMCID:PMC5534076

2012

• Jiang XF, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q. 2012. A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in beta 2-adrenergic receptor internalization and down-regulation. FASEB J 26:1995-2007. doi:10.1096/fj.11-193870 PMID:22278941 PMCID:PMC3336790
• Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q. 2012. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A 109(11):4146-4151. doi:10.1073/pnas.1200448109 PMID:22315426 PMCID:PMC3306724
• Oh RS, Pan W, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu Q. 2012. Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. J Biol Chem 287(8):6025-6034. doi:10.1074/jbc.M111.311217 PMID:22215663 PMCID:PMC3285369
• Stansfield KH, Pilsner JR, Lu Q, Wright RO, Guilarte TR. 2012. Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): Implications for an environmental basis of neurodevelopmental disorders. Toxicol Sci 127:277-295. doi:10.1093/toxsci/kfs090 PMID:22345308 PMCID:PMC3327871