Skip Navigation

Person Details: Tom K. Hei

Superfund Research Program

Tom K. Hei

Columbia University Mailman School of Public Health
Department of Environmental Health Sciences
New York, New York 10032
Phone: 212-305-8462
Fax: 212-305-3229


Research Briefs






  • Ivanov VN, Zhou HZ, Partridge MA, Hei TK. 2009. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer Res 69(8):3510-3519. doi:10.1158/0008-5472.CAN-08-3883 PMID:19351839 PMCID:PMC4070218
  • Partridge MA, Huang SX, Ahsan H, Davidson MM, Hei TK, Kibriya MG. 2009. Environmental mutagens induced transversions but not transitions in regulatory region of mitochondrial DNA. J Toxicol Environ Health A 72(5):301-304. doi:10.1080/15287390802526381 PMID:19184745
  • Wen G, Partridge MA, Calaf GM, Meador JA, Hu B, Echiburu-Chau C, Hong M, Hei TK. 2009. Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment. Sci Total Environ 407(3):1174-1181. doi:10.1016/j.scitotenv.2008.09.045 PMID:18977016



  • Partridge MA, Huang SX, Hernandez-Rosa E, Davidson MM, Hei TK. 2007. Arsenic induced mitochondrial DNA damage and alteredmitochondrial oxidative function: implication for genotoxic mechanismsin mammalian cells. Cancer Res 67(11):5239-5247.
  • Patridge M, Davidson MM, Hei TK. 2007. The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA. DNA Seq 18(5):341-346. doi:10.1080/10425170601101287 PMID:17654009
  • Vladimir I, Zhou HZ, Hei TK. 2007. Gamma-irradiation or alpha-particle exposure sensitize human melanoma cells to TRAIL-mediated apoptosis through upregulation of TRAIL R2/DR5 expression and translocation to the cell surface. Cancer Res 67:5397-5407.
  • Vladimir I, Zhou HZ, Hei TK. 2007. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res 67(11):5397-5407. PMID:17545621
  • Xu A, Huang SX, Lien Y, Bao L, Yu Z, Hei TK. 2007. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chem Res Toxicol 20(5):724-33. PMID:17447795
  • Xu A, Smilenov LB, He P, Masumura K, Nohmi T, Yu Z, Hei TK. 2007. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ Health Perspect 115(1):87-92. PMID:17366825 PMCID:PMC1797839


  • Ivanov VN, Hei TK. 2006. Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Exp Cell Res 312(8):1401-1417. PMID:16487513
  • Ivanov VN, Hei TK. 2006. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res 312(20):4120-4138. PMID:17070520
  • Ivanov VN, Ronai Z, Hei TK. 2006. Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis. J Biol Chem 281(3):1840-1852. PMID:16306044
  • Zhou HZ, Xu A, Gillispie JA, Waldren CA, Hei TK. 2006. Quantification of CD59- mutants in human-hamster hybrid (AL) cells by flow cytometry. Mutat Res 594(1-2):113-119. doi:10.1016/j.mrfmmm.2005.08.009 PMID:16253292


  • Liu S, Davidson MM, Tang X, Walker WF, Athar M, Ivanov VN, Hei TK. 2005. Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells. Cancer Res 65(8):3236-3242. PMID:15833855


  • Filipic M, Hei TK. 2004. Mutagenicity of cadmium in mammalian cells: Implication of oxidative DNA damage. Mutat Res 546:81-94. PMID:14757196
  • Hei TK, Filipic M. 2004. Role of oxidative damage in the genotoxicity of arsenic. Free Radic Biol Med 37(5):574-581. PMID:15288115
  • Hei TK, Persaud R, Zhou HZ, Suzuki M. 2004. Genotoxicity in the eyes of bystander cells. Mutat Res 568(1):111-120. PMID:15530544
  • Ivanov VN, Hei TK. 2004. Arsenic sensitizes human melanomas to apoptosis via TNF-alpha mediated pathways. J Biol Chem 279(21):22747-22758. PMID:15028728


  • Hall EJ, Hei TK. 2003. Genomic instability and bystander effects induced by high-LET radiation. Oncogene 22:7034-7042. PMID:14557808
  • Zhou HZ, Randes-Pehrson G, Geard CR, Brenner DJ, Hall EJ, Hei TK, Ahmed KM. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research 160(5):512-516. PMID:14565832 PMCID:PMC4041543


  • Kessel M, Liu S, Xu A, Santella RM, Hei TK. 2002. Arsenic induces oxidative DNA damage in mammalian cells. Mol Cell Biochem 234-235:301-308. PMID:12162448
  • Xu A, Zhou HZ, Yu DZ, Hei TK. 2002. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environ Health Perspect 110:1003-1008. PMID:12361925


  • Liu S, Athar M, Lippai I, Waldren CA, Hei TK. 2001. Induction of oxyradicals by arsenic: Implication for mechanisms of genotoxicity. Proc Natl Acad Sci U S A 98(4):1643-1648. PMID:11172004


  • Hei TK, Liu S, Waldren CA. 1998. Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species. Proc Natl Acad Sci U S A 95:8103-8107. PMID:9653147
to Top