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Person Details

Superfund Research Program

Tom K. Hei

Columbia University Mailman School of Public Health
Department of Environmental Health Sciences
New York, NY 10032
Phone: 212-305-8462
Fax: 212-305-3229
Email: tkh1@columbia.edu

Projects

Research Briefs

Publications

2012

2011

  • Huang SX, Jaurand MC, Kamp DW, Whysner J, Hei TK. 2011. Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases. Journal of Toxicology & Environmental Health Part B: Critical Reviews 14:179-245. doi:10.1080/10937404.2011.556051
  • Ivanov VN, Hei TK. 2011. Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy. Apoptosis 16(12):1268-1284. doi:10.1007/s10495-011-0649-2
  • Ivanov VN, Partridge MA, Huang SL, Hei TK. 2011. Suppression of the Proinflammatory Response of Metastatic Melanoma Cells Increases TRAIL-Induced Apoptosis. J Cell Biochem112(2):463-475. doi:10.1002/jcb.22934
  • Wen G, Hong M, Li B, Liao W, Cheng SK, Hu B, Calaf GM, Lu P, Partridge MA, Tong J, Hei TK. 2011. Transforming growth factor-B-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway. Int J Oncol39(4):1001-1009. doi:10.3892/ijo.2011.1097

2010

  • Karasic T, Hei TK, Ivanov VN. 2010. Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma. Exp Cell Res 316(12):1994-2007. doi:10.1016/j.yexcr.2010.04.014
  • Roy D, Hei TK, Li B, Wen G, Hong M, Calaf GM, Partridge MA. 2010. Phosphoproteomic profiling of arsenite-treated human small airway epithelial cells. Oncol Rep23(2):405-412. doi:10.3892/or_00000649

2009

2008

  • Ivanov VN, Partridge MA, Johnson GE, Huang SL, Zhou HZ, Hei TK. 2008. Resveratrol sensitizes human melanomas to TRAIL through modulation of anti-apoptotic gene expression in conditions of partial suppression of mitochondrial function. Exp Cell Res 314(5):1163-1176. doi:10.1016/j.yexcr.2007.12.012
  • Wen G, Calaf GM, Partridge MA, Echiburu-Chau C, Zhao Y, Huang SL, Chai Y, Li B, Hu B, Hei TK. 2008. Neoplastic transformation of human small airway epithelial cells induced by arsenic. Molecular Medicine14(1-2):2-10. doi:10.2119/2007-00090.Wen

2007

  • Partridge MA, Huang SX, Hernandez-Rosa E, Davidson MM, Hei TK. 2007. Arsenic induced mitochondrial DNA damage and alteredmitochondrial oxidative function: Implication for genotoxic mechanismsin mammalian cells. Cancer Res67(11):5239-5247.
  • Patridge M, Davidson MM, Hei TK. 2007. The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA sequence. DNA Sequence18(5):341-346.
  • Vladimir I, Zhou HZ, Hei TK. 2007. Gamma-irradiation or alpha-particle exposure sensitize human melanoma cells to TRAIL-mediated apoptosis through upregulation of TRAIL R2/DR5 expression and translocation to the cell surface. Cancer Res67:5397-5407.
  • Vladimir I, Zhou HZ, Hei TK. 2007. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res67(11):5397-5407.
  • Xu A, Huang SX, Lien Y, Bao L, Yu Z, Hei TK. 2007. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chem Res Toxicol20(5):724-33.
  • Xu A, Smilenov LB, He P, Masumura K, Nohmi T, Yu Z, Hei TK. 2007. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ Health Perspect 115(1):87-92.

2006

  • Ivanov VN, Hei TK. 2006. Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Exp Cell Res 312(8):1401-1417.
  • Ivanov VN, Hei TK. 2006. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res 312(20):4120-4138.
  • Ivanov VN, Ronai Z, Hei TK. 2006. Opposite Roles of FAP-1 and Dynamin in the Regulation of Fas (CD95) Translocation to the Cell Surface and Susceptibility to Fas Ligand-mediated Apoptosis. Journal of Biological Chemistry281(3):1840-1852.
  • Zhou HZ, Xu A, Gillispie JA, Waldren CA, Hei TK. 2006. Quantification of CD59-mutants in human-hamster hybrid (AL) cells by flow cytometry. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis594(1-2):113-119.

2005

  • Liu S, Davidson MM, Tang X, Walker WF, Athar M, Ivanov VN, Hei TK. 2005. Mitochondrial Damage Mediates Genotoxicity of Arsenic in Mammalian Cells. Cancer Res65(8):3236-3242.

2004

2003

  • Hall EJ, Hei TK. 2003. Genomic instability and bystander effects induced by high-LET radiation. Oncogene22:7034-7042.
  • Zhou HZ, Randes-Pehrson G, Geard CR, Brenner DJ, Hall EJ, Hei TK, Ahmed KM. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiat Res160(5):512-516.

2002

  • Kessel M, Liu S, Xu A, Santella RM, Hei TK. 2002. Arsenic induces oxidative DNA damage in mammalian cells. Mol Cell Biochem234-235:301-308.
  • Xu A, Zhou HZ, Yu DZ, Hei TK. 2002. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environ Health Perspect 110:1003-1008.

2001

1998

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