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Your Environment. Your Health.

Person Details

Superfund Research Program

Tom K. Hei

Columbia University Mailman School of Public Health
Department of Environmental Health Sciences
New York, NY 10032
Phone: 212-305-8462
Fax: 212-305-3229


Research Briefs








  • Partridge MA, Huang SX, Hernandez-Rosa E, Davidson MM, Hei TK. 2007. Arsenic induced mitochondrial DNA damage and alteredmitochondrial oxidative function: Implication for genotoxic mechanismsin mammalian cells. Cancer Res 67(11):5239-5247.
  • Patridge M, Davidson MM, Hei TK. 2007. The complete nucleotide sequence of Chinese hamster (Cricetulus griseus) mitochondrial DNA sequence. DNA Sequence 18(5):341-346. doi:10.1080/10425170601101287 PMID:17654009
  • Vladimir I, Zhou HZ, Hei TK. 2007. Gamma-irradiation or alpha-particle exposure sensitize human melanoma cells to TRAIL-mediated apoptosis through upregulation of TRAIL R2/DR5 expression and translocation to the cell surface. Cancer Res 67:5397-5407.
  • Vladimir I, Zhou HZ, Hei TK. 2007. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res 67(11):5397-5407.
  • Xu A, Huang SX, Lien Y, Bao L, Yu Z, Hei TK. 2007. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chem Res Toxicol 20(5):724-33.
  • Xu A, Smilenov LB, He P, Masumura K, Nohmi T, Yu Z, Hei TK. 2007. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ Health Perspect 115(1):87-92.


  • Ivanov VN, Hei TK. 2006. Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Exp Cell Res 312(8):1401-1417.
  • Ivanov VN, Hei TK. 2006. Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res 312(20):4120-4138.
  • Ivanov VN, Ronai Z, Hei TK. 2006. Opposite Roles of FAP-1 and Dynamin in the Regulation of Fas (CD95) Translocation to the Cell Surface and Susceptibility to Fas Ligand-mediated Apoptosis. Journal of Biological Chemistry 281(3):1840-1852.
  • Zhou HZ, Xu A, Gillispie JA, Waldren CA, Hei TK. 2006. Quantification of CD59-mutants in human-hamster hybrid (AL) cells by flow cytometry. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 594(1-2):113-119.


  • Liu S, Davidson MM, Tang X, Walker WF, Athar M, Ivanov VN, Hei TK. 2005. Mitochondrial Damage Mediates Genotoxicity of Arsenic in Mammalian Cells. Cancer Res 65(8):3236-3242.



  • Hall EJ, Hei TK. 2003. Genomic instability and bystander effects induced by high-LET radiation. Oncogene 22:7034-7042.
  • Zhou HZ, Randes-Pehrson G, Geard CR, Brenner DJ, Hall EJ, Hei TK, Ahmed KM. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiat Res 160(5):512-516.


  • Kessel M, Liu S, Xu A, Santella RM, Hei TK. 2002. Arsenic induces oxidative DNA damage in mammalian cells. Mol Cell Biochem 234-235:301-308.
  • Xu A, Zhou HZ, Yu DZ, Hei TK. 2002. Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environ Health Perspect 110:1003-1008.



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