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Person Details: Patricia E. Ganey

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Superfund Research Program

Patricia E. Ganey

Michigan State University
Department of Pharmacology/Toxicology
214 Food Safety and Toxicology Building
East Lansing, Michigan 48824
Phone: 517-432-1761
Fax: 517-432-2310


Research Briefs



  • Olivero-Verbal J, Harkema JR, Roth RA, Ganey PE. 2021. Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, blocks steatosis and alters the inflammatory response in a mouse model of inflammation-dioxin interaction. Chem Biol Interact 345:PMID:34052195



  • Olivero-Verbal J, Roth RA, Ganey PE. 2011. Dioxin alters inflammatory responses to lipopolysaccharide. Toxicol Sci 93:1180-1194. doi:10.1080/02772248.2011.577554



  • Bezdecny SA, Roth RA, Ganey PE. 2005. Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. Toxicol Sci 84(2):328-334. doi:10.1093/toxsci/kfi093 PMID:15673847
  • Luster-Teasley SL, Ganey PE, DiOrio M, Ward JS, Maleczka RE, Trosko JE, Masten S. 2005. Effect of byproducts from the ozonation of pyrene: Biphenyl-2,2 ',6,6 '-tetracarbaldehyde and biphenyl-2,2 ',6,6 '-tetracarboxylic acid on gap junction intercellular communication and neutrophil function. Environ Toxicol Chem 24(3):733-740. PMID:15786580


  • Bezdecny SA, Roth RA, Ganey PE. 2003. Expression of cyclooxygenase-2 in HL-60 cells exposed to polychlorinated biphenyls. Toxicol Sci 72(1):1571Suppl.S..


  • Olivero J, Bezdecny SA, Ganey PE. 2002. A molecular motif required for the activation of rat neutrophil Phospholipase A2 by organochlorine compounds. Chem Res Toxicol 15(2):153-159.


  • Olivero J, Ganey PE. 2001. Participation of Ca2+/calmodulin during activation of rat neutrophils by polychlorinated biphenyls. Biochem Pharmacol 62:1125-1132. PMID:11597581


  • Ganey PE, Olivero-Verbal J, Madhukar BV. 2000. Mechanism of inhibition of stimulated neutrophil degranulation by 2,2',4,4'-tetrachlorobiphenyl. Toxicol Sci 54:77.
  • Ganey PE, Quensen JF, Mousa MA, Boyd SA, Wagner JG, Fischer L. 2000. Biological activity associated with noncoplanar polychlorinated biphenyls after microbial dechlorination of Aroclor 1242 and Aroclor 1254. Environ Toxicol Chem 19:1311-1316.
  • Olivero-Verbal J, Ganey PE. 2000. A common elecrotopological motif among organochlorine compounds that activate neutrophils. Toxicol Sci 54:77.
  • Olivero-Verbal J, Ganey PE. 2000. Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242. Toxicol Appl Pharmacol 163:9-16. PMID:10662600
  • Tithof PK, Olivero J, Ruehle K, Ganey PE. 2000. Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds. Toxicol Sci 53(1):40-47. PMID:10653519


  • Fischer L, Seegal R, Ganey PE, Pessah IN, Kodavanti PR. 1998. Symposium overview: toxicity of non-coplanar PCBs. Toxicol Sci 41(1):49-61. doi:10.1006/toxs.1997.2386 PMID:9520341
  • Mousa MA, Ganey PE, Quensen JF, Madhukar BV, Chou K, Giesy JP, Fischer L, Boyd SA. 1998. Altered biological activity of commercial PCB mixtures due to microbial reductive dechlorination. In: Proceedings of the 17th International Symposium on Chlorinated Dioxins and Related Compounds. pp.1-5.
  • Narayanan PK, Carter WO, Ganey PE, Roth RA, Voytik-Harbin SL, Robinson JP. 1998. Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity. J Leukoc Biol 63:216-224. PMID:9468280
  • Tithof PK, Peters-Golden M, Ganey PE. 1998. Distinct phospholipases A2 regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils. J Immunol 160:953-960. PMID:9551934


  • Tithof PK, Watts S, Ganey PE. 1997. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. Biochem Pharmacol 53:1833-1842. PMID:9256158


  • Brown AP, Schultze AE, Holdan W, Buchweitz JP, Roth RA, Ganey PE. 1996. Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls. Environ Health Perspect 104(6):634-640. PMID:8793352
  • Ho JS, Buchweitz JP, Roth RA, Ganey PE. 1996. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes. J Leukoc Biol 59:716-724. PMID:8656057
  • Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA. 1996. Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 139:213-226. PMID:8806837
  • Tithof PK, Peters-Golden M, Schiamburg L, Ganey PE. 1996. Aroclor 1242 activates neutrophils by a mechanism which involves phospholipase A2. Environ Health Perspect 104:52-58.
  • Wagner JG, Ganey PE, Roth RA. 1996. Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucyl-phenylalanine or phorbol myristate acetate in vitro. Hepatology 23(4):803-810. PMID:8666335


  • Brown AP, Ganey PE. 1995. Neutrophil degranulation and superoxide production induced by polychlorinated biphenyl are calcium dependent. Toxicol Appl Pharmacol 131(2):198-205. PMID:7716762
  • Tithof PK, Contreras ML, Ganey PE. 1995. Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils. Toxicol Appl Pharmacol 131:136-143. PMID:7878669
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