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Person Details: Isaac I. Wirgin

Superfund Research Program

Isaac I. Wirgin

New York University School of Medicine
Department of Environmental Medicine
SLF 254B
57 Old Forge Road
Tuxedo, New York 10987
Phone: 845-731-3548
Fax: 845-351-5472


Research Briefs

Hazardous Waste Sites

Diamond Alkali Co.

  • New York University School of Medicine: Mechanisms of Resistance of Aquatic Vertebrate Populations to Mixtures of Aromatic Hydrocarbons and Metal Contaminants

Hudson River PCBs

  • New York University School of Medicine: Mechanisms of Resistance of Aquatic Vertebrate Populations to Mixtures






  • Carlson E, Roy NK, Wirgin II. 2009. Microarray analysis of polychlorinated biphenyl mixture-induced changes in gene expression among Atlantic tomcod populations displaying differential sensitivity to halogenated aromatic hydrocarbons. Environ Toxicol Chem 28:759-771. doi:10.1897/08-195R.1 PMID:19391682


  • Roy NK, Courtenay SC, Chambers RC, Wirgin II. 2006. Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations. Environ Toxicol Chem 25(2):560-571. PMID:16519320
  • Wirgin II, Weis JS, McElroy AE. 2006. Physiological and genetic aspects of toxicity in Hudson River species. Chapter 30 in: The Hudson River Estuary. Cambridge University Press, New York, NY. pp.441-464.
  • Yuan Z, Courtenay SC, Chambers RC, Wirgin II. 2006. Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River. Environ Health Perspect 114(1):77-84. PMID:16393662
  • Yuan Z, Courtenay SC, Wirgin II. 2006. Comparison of hepatic and extra hepatic induction of cytochrome P4501A by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. Aquat Toxicol 76(3-4):306-320. PMID:16313980


  • Sorrentino C, Roy NK, Courtenay SC, Wirgin II. 2005. Co-exposure to metals modulates CYP1A1 mRNA inducibility in Atlantic tomcod Microgadus tomcod from two populations. Aquat Toxicol 75(3):238-252. PMID:16183146
  • Wirgin II, Chambers RC. 2005. Atlantic tomcod (Microgadus tomcod): A model species for the response of Hudson River fish to toxicants. In: Hudson River Fishes and their Environment. (Waldman JR, Limburg KE, Strayer D, eds). Amer. Fish. Soc,
  • Wirgin II, Grunwald C, Carlson E, Stabile J, Peterson DL, Waldman JR. 2005. Range-wide population structure of shortnose sturgeon Acipenser brevirostrum based on sequence analysis of the mitochondrial DNA control region. Estuaries 28(3):406-421.


  • Couillard CM, Wirgin II, Lebeuf M, Legare B. 2004. Reduction of cytochrome P4501A with age in Atlantic tomcod from the St. Lawrence Estuary, Canada: relationship with emaciation and possible effect of contamination. Aquat Toxicol 68(3):233-247. PMID:15159050
  • Fernandez MP, Ikonomou MG, Courtenay SC, Wirgin II. 2004. Spatial variation in hepatic levels and patterns of PCBs and PCDD/Fs among young-of-the-year and adult Atlantic tomcod (Microgadus tomcod) in the Hudson River estuary. Environ Sci Technol 38(4):976-983. PMID:14998007
  • Sorrentino C, Roy NK, Chambers RC, Courtenay SC, Wirgin II. 2004. B[a]P-DNA binding in early life-stages of Atlantic tomcod: population differences and chromium modulation. Mar Environ Res 58(2-5):383-388. doi:10.1016/j.marenvres.2004.03.024 PMID:15178057
  • Wirgin II, Waldman JR. 2004. Resistance to contaminants in North American fish populations. Mutat Res 552(1-2):73-100. PMID:15288543


  • Roy NK, Courtenay SC, Maxwell G, Yuan Z, Chambers RC, Wirgin II. 2002. Cytochrome P4501A1 is induced by PCB 77 and benzo[a]pyrene treatment but not by exposure to the Hudson River environment in Atlantic tomcod (Microgadus tomcod) post-yolk sac larvae. Biomarkers 7(2):162-173.


  • Roy NK, Courtenay SC, Yuan Z, Ikonomou MG, Wirgin II. 2001. An evaluation of the etiology of reduced CYP1A1 messenger RNA expression in the Atlantic tomcod from the Hudson River, New York, USA, using reverse transcriptase polymerase chain reaction analysis. Environ Toxicol Chem 20(5):1022-1030. PMID:11337864
  • Walsh MG, Bain MB, Squiers T, Waldman JR, Wirgin II. 2001. Morphological and genetic variation among shortnose sturgeon Acipenser brevirostrum from adjacent and distant rivers. Estuaries 24:41-48.
  • Wirgin II, Oppermann T, Stabile J. 2001. Genetic divergence of robust redhorse Moxostoma robustum (Cypriniformes Catostomidae) from the Oconee River and the Savannah River based on mitochondrial DNA control region sequences. Copeia 526-530.
  • Yuan Z, Wirgin M, Courtenay SC, Ikonomou MG, Wirgin II. 2001. Is hepatic cytochrome P4501A1 expression predictive of hepatic burdens of dioxins, furans, and PCBs in Atlantic tomcod from the Hudson River estuary?. Aquat Toxicol 54(3-4):217-230. PMID:11489308
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