Superfund Research Program

Robert Clark Lantz

University of Arizona
Department of Cell Biology and Anatomy
Life Sciences North 447
1333 N. Martin Ave.
Tucson, Arizona 85724-5044
Phone: 520-626-6716
Fax: 520-626-2097
Email: lantz@email.arizona.edu

Projects

• University of Arizona: Administrative Core (2000-2025)
• University of Arizona: Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust (2017-2020)
• University of Arizona: Toxicological Impact of Mine Tailings Dust on Lung Epithelial Barrier Function (2005-2020)

Research Briefs

• 159 - Research Brief 159: In utero and Early Postnatal Exposure to Arsenic May Alter Pulmonary Function

Hazardous Waste Sites

Iron King Mine and Humboldt Smelter

• University of Arizona: Toxicological Impact of Mine Tailings Dust on Lung Epithelial Barrier Function

Publications

2021

• Chau BT, Witten M, Cromey DW, Chen Y, Lantz RC. 2021. Lung developmental is altered after inhalation exposure to various concentrations of calcium arsenate. Toxicol Appl Pharmacol 432:115754. doi:10.1016/j.taap.2021.115754 PMID:34634286 PMCID:PMC8572171

2020

• Michel-Ramirez G, Recio-Vega R, Lantz RC, Gandolfi A, Olivas-Calderon E, Chau BT, Amistadi M. 2020. Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer. J Appl Toxicol 40(3):342-351. doi:10.1002/jat.3907 PMID:31631368 PMCID:PMC7012748
• Recio R, Hernandez Gonzalez S, Michel-Ramirez G, Olivas-Calderon E, Lantz RC, Gandolfi A, Amistadi M. 2020. Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P-gp) with lung cancer in a Mexican cohort. J Appl Toxicol 9:doi:10.1002/jat.4127 PMID:33340130

2019

• Witten M, Chau BT, Saez AE, Boitano S, Lantz RC. 2019. Early life inhalation exposure to mine tailings dust affects lung development. Toxicol Appl Pharmacol 365:124-132. doi:10.1016/j.taap.2019.01.009 PMID:30641074 PMCID:PMC6349506

2018

• Thomas AN, Root RA, Lantz RC, Saez AE, Chorover J. 2018. Oxidative weathering decreases bioaccessibility of toxic metal(loid)s in PM10 emissions from sulfide mine tailings. Geohealth 2(4):118-138. doi:10.1002/2017GH000118 PMID:30338309 PMCID:PMC6191178
• Yellowhair M, Romanotto MR, Stearns DM, Lantz RC. 2018. Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38. doi:10.1016/j.taap.2018.04.022 PMID:29698738 PMCID:PMC5972677

2017

• Michel-Ramirez G, Recio-Vega R, Ocampo-Gomez G, Palacios-Sanchez E, Delgado-Macias M, Delgado-Gaona M, Lantz RC, Gandolfi A, Gonzalez-Cortes. 2017. Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels. J Appl Toxicol 37:1195-1202. doi:10.1002/jat.3481 PMID:28524356
• Smeester L, Bommarito P, Martin EM, Recio-Vega R, Gonzalez-Cortes, Olivas-Calderon E, Lantz RC, Fry RC. 2017. Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response. Environ Toxicol Pharmacol 52:183-187. doi:10.1016/j.etap.2017.04.007 PMID:28433805

2016

• Beamer P, Klimecki WT, Loh M, Van Horne YO, Sugeng AJ, Lothrop N, Billheimer D, Guerra S, Lantz RC, Canales RA, Martinez FD. 2016. Association of children's urinary CC16 levels with arsenic concentrations in multiple environmental media. Int J Environ Res Public Health 13(5):521. doi:10.3390/ijerph13050521 PMID:27223295 PMCID:PMC4881146
• Recio-Vega R, Gonzalez-Cortes, Olivas-Calderon E, Gandolfi A, Michel-Ramirez G, Lantz RC. 2016. Association between polymorphisms in arsenic metabolism genes and urinary arsenic methylation profiles in girls and boys chronically exposed to arsenic. Environ Mol Mutagen 57(7):516-525. doi:10.1002/em.22026 PMID:27327299 PMCID:PMC4980171

2015

• Olivas-Calderon E, Recio-Vega R, Gandolfi A, Lantz RC, Gonzalez-Cortes, Gonzalez-De Alba C, Froines JR, Espinosa-Fematt JA. 2015. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic. Toxicol Appl Pharmacol 287(2):161-167. doi:10.1016/j.taap.2015.06.001 PMID:26048584 PMCID:PMC4751871
• Recio-Vega R, Gonzalez-Cortes, Olivas-Calderon E, Lantz RC, Gandolfi A, Gonzalez-De Alba C. 2015. In utero and early childhood exposure to arsenic decreases lung function in children. J Appl Toxicol 35(4):358-366. doi:10.1002/jat.3023 PMID:25131850 PMCID:PMC4750377
• Sherwood CL, Lantz RC. 2015. Lung cancer and other pulmonary diseases. Chapter 9 in: Arsenic: Exposure Sources, Health Risks, and Mechanisms of Toxicity. John Wiley & Sons, Hoboken, NJ. pp.342-386.
• Stanton BA, Caldwell KL, Congdon CB, Disney J, Donahue M, Ferguson E, Flemings E, Golden M, Guerinot ML, Highman J, James K, Kim C, Lantz RC, Marvinney RG, Miller D, Navas-Acien A, Nordstrom D, Postema S, Rardin LR, Rosen BP, Sengupta A, Shaw JR, Stanton E, Susca P. 2015. MDI biological laboratory arsenic summit: approaches to limiting human exposure to arsenic. Curr Environ Health Rep 2(3):329-337. doi:10.1007/s40572-015-0057-9 PMID:26231509 PMCID:PMC4522277

2014

• Burgess JL, Kurzius-Spencer M, Poplin GS, Littau S, Kopplin MJ, Sturup S, Boitano S, Lantz RC. 2014. Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin. J Expo Sci Environ Epidemiol 24(2):150-155. doi:10.1038/jes.2013.35 PMID:23838883 PMCID:PMC4019207

2013

• Sherwood CL, Lantz RC, Boitano S. 2013. Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells. Toxicol Sci 132:222-234. doi:10.1093/toxsci/kfs331 PMID:23204110 PMCID:PMC3576008
• Sherwood CL, Liguori AE, Olsen CE, Lantz RC, Burgess JL, Boitano S. 2013. Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures. PLoS One 8(12):e82970. doi:10.1371/journal.pone.0082970 PMID:24349408 PMCID:PMC3857810
• Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD. 2013. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal 19(14):1647-1661. doi:10.1089/ars.2012.5117 PMID:23394605 PMCID:PMC3809600

2012

• Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. 2012. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol 265(3):292-299. doi:10.1016/j.taap.2012.08.028 PMID:22975029 PMCID:PMC3725323

2011

• Sherwood CL, Lantz RC, Burgess JL, Boitano S. 2011. Arsenic alters ATP-dependent Ca2+ signaling in human airway epithelial cell wound response. Toxicol Sci 121:191-206. doi:10.1093/toxsci/kfr044 PMID:21357385 PMCID:PMC3080191
• States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC. 2011. Arsenic toxicology: translating between experimental models and human pathology. Environ Health Perspect 119:1356-1363. doi:10.1289/ehp.1103441 PMID:21684831 PMCID:PMC3230447

2009

• Lantz RC, Witten M, Chau BT, Sarihan P, Pivniouk V, Chen GJ. 2009. In utero and postnatal exposure to arsenic alters pulmonary structure and function. Toxicol Appl Pharmacol 235(1):105-113. doi:10.1016/j.taap.2008.11.012 PMID:19095001 PMCID:PMC2669654

2008

• Andrew AS, Lantz RC, Rodgers, LS, Vaillancourt RR, Camenisch TD, Hays AM, Sollome JJ, Hamilton JW. 2008. Arsenic-induced decreases in the vascular matrix. Toxicol Pathol 36(6):805-817. doi:10.1177/0192623308323919 PMID:18812580 PMCID:PMC2875876
• Petrick JS, Blachere FM, Selmin O, Lantz RC. 2008. Inorganic arsenic as a developmental toxicant: in utero exposure and alterations in the developing rat lungs. Mol Nutr Food Res 53(5):583-591. PMID:19072884

2007

• Burgess JL, Montenegro M, Josyula AB, Poplin GS, Kopplin MJ, Rowland H, Sturup S, Lantz RC. 2007. Environmental arsenic exposure and urinary 8-OHdG in Arizona and Sonora. Clinical Toxicology 45(5):490-8. PMID:17503254
• Lantz RC, Lynch BJ, Boitano S, Poplin GS, Littau S, Tsaprailis G, Burgess JL. 2007. Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic. Environ Health Perspect 115(4):586-91. PMID:17450228

2006

• Josyula AB, Poplin GS, Kurzius-Spencer M, McClellen HE, Kopplin MJ, Sturup S, Lantz RC, Burgess JL. 2006. Environmental arsenic exposure and sputum metalloproteinase concentrations. Environ Res 102(3):283-290. doi:10.1016/j.envres.2006.01.003 PMID:16487958
• Lantz RC, Hays AM. 2006. Role of oxidative stress in arsenic-induced toxicity. J Mol Biol 38(4):791-804. PMID:17145702

2002

• Petrick JS, Blachere FM, Greer KA, Schwartz MA, Scholz MJ, Selmin O, Runyan RB, Hoying JB, Lantz RC. 2002. Arsenic targets the developing rat lung: gene expression alterations following chronic low-dose exposure. In: Symposium on Arsenic in New England, May 29-31. Manchester, NH.
• Petrick JS, Blachere FM, Greer KA, Schwartz MA, Scholz MJ, Selmin O, Runyan RB, Hoying JB, Lantz RC. 2002. Chronic low-level arsenic exposure induces aberrant gene expression in the lung. In: Proceedings of the Fifth International Conference on Arsenic Exposure and Health Effects, July 14-18. San Diego, CA.
• Petrick JS, Blachere FM, Selmin O, Runyan RB, Lantz RC. 2002. Arsenic induces aberrant gene expression during lung development: Application of toxicogenomics. In: Proceedings of the Science Fair 2002, (Superfund Basic Research Program) SBRP and SWEHSC (Southwest Environmental Health Sciences Center), May 17. University of Arizona, Tucson, AZ. pp.10.
• Petrick JS, Blachere FM, Selmin O, Runyan RB, Lantz RC. 2002. Arsenic induces aberrant gene expression during lung development: Application of toxicogenomics. In: Proceedings of the 41^st Annual Meeting of the Society of Toxicology (SOT), March 17-21, 2002. Nashville, TN.

2001

• Wijeweera JB, Gandolfi A, Parrish AR, Lantz RC. 2001. Sodium arsenite enhances AP-1 and NFKB DNA binding and induces stress protein expression in precision-cut rat lung slices. Toxicol Sci 61(2):283-294. PMID:11353137