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Your Environment. Your Health.

Person Details

Superfund Research Program

Leena A. Nylander-French

University of North Carolina-Chapel Hill
Department of Environmental Sciences and Engineering
CB #7431, 159 Rosenau Hall
Chapel Hill, NC 27599-7431
Phone: 919-966-3826


Research Briefs




  • Kang-Sickel JC, Butler MA, Frame L, Serdar B, Chao YE, Egeghy PP, Rappaport SM, Toennis CA, Li W, Borisova T, French JE, Nylander-French LA. 2011. The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure. Biomarkers 16:590-599. doi:10.3109/1354750x.2011.611598


  • Kang-Sickel JC, Stober V, French JE, Nylander-French LA. 2010. Exposure to naphthalene induces naphthyl-keratin adducts in human epidermis in vitro and in vivo. Biomarkers 15:488-497. doi:10.3109/1354750x.2010.485700


  • Kim D, Nylander-French LA. 2009. Physiologically-Based Toxicokinetic Models and Their Application in Human Exposure and Internal Dose Assessment. In: Molecular, Clinical and Environmental Toxicology Volume 1. pp.470.


  • Chao YE, Zhao Y, Kupper LL, Nylander-French LA. 2008. Quantifying the relative importance of predictors in multiple linear regression analyses for public health studies. J Occup Environ Hyg 5(8):519-529. doi:10.1080/15459620802225481
  • Kang-Sickel JC, Nam T, Jayaraj K, Ball LM, French JE, Klapper DG, Gold A, Nylander-French LA. 2008. S-arylcysteine-keratin adducts as biomarkers of human dermal exposure to aromatic hydrocarbons. Chem Res Toxicol 21(4):852-858.
  • Kim D, Farthing MW, Miller CT, Nylander-French LA. 2008. Mathematical description of the uptake of hydrocarbons in jet fuel across the Stratum Corneum of human volunteers. Toxicol Lett 178(3):146-151. doi:10.1016/j.toxlet.2008.03.005


  • Kim D, Andersen ME, Chao YE, Egeghy PP, Rappaport SM, Nylander-French LA. 2007. Human Dermal and Inhalation Exposures to Jet Fuel Can Be Predicted Using a PBTK Model. Environ Health Perspect 115(6):894-901. doi:10.1289/ehp.9778 PMID:17589597 PMCID:PMC1892111
  • Kim D, Andersen ME, Chao YE, Egeghy PP, Rappaport SM, Nylander-French LA. 2007. PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene. Environ Health Perspect 115:894-901.
  • Kim D, Andersen ME, Chao YE, Egeghy PP, Rappaport SM, Nylander-French LA. 2007. Prediction of human dermal and inhalation exposures to jet fuel by analysis of a PBTK model. Environ Health Perspect 115(6):894-901.


  • Chao YE, Kupper LL, Serdar B, Egeghy PP, Rappaport SM, Nylander-French LA. 2006. Dermal exposure to jet fuel JP-8 significantly contributes to production of urinary naphthols in fuel-cell maintenance workers. Environ Health Perspect 114(2):182-185. doi:10.1289/ehp.8288
  • Kang-Sickel JC, Gold A, Ball LM, Karupiah J, Nylander-French LA, Parron V, Klapper DG, French JE. 2006. Detection of naphthalene keratin adducts in human skin using ELISA. Drug Metab Rev 38(Suppl.2):67-68.
  • Kim D, Andersen ME, Nylander-French LA. 2006. A dermatotoxicokinetic model of human exposures to jet fuel. Toxicological Sciences 93(1):22-33. PMID:16801332
  • Kim D, Andersen ME, Nylander-French LA. 2006. Dermal absorption and penetration of jet fuel components in humans. Toxicol Lett 165(1):11-21. doi:10.1016/j.toxlet.2006.01.009 PMID:16497449
  • Serdar B, Tornero-Velez R, Echeverria D, Nylander-French LA, Kupper LL, Rappaport SM. 2006. Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industry. Occup Environ Med 63(10):707-12.


  • Chao YE, Gibson RL, Nylander-French LA. 2005. Dermal Exposure to Jet Fuel (JP-8) in US Air Force Personnel. Annals of Occupational Hygiene 49(7):639-645.


  • Chao YE, Nylander-French LA. 2004. Determination of keratin protein in a tape-stripped skin sample from jet fuel exposed skin. Annals of Occupational Hygiene 48(1):65-73.
  • Mattorano DA, Kupper LL, Nylander-French LA. 2004. Estimating dermal exposure to jet fuel (naphthalene) using adhesive tape strip samples. Annals of Occupational Hygiene 48(2):139-146.


  • Gold A, Nam T, Jayaraj K, Sangaiah R, Klapper DG, Ball LM, French JE, Nylander-French LA. 2003. Synthesis of S-aryl-D,L-cysteines and incorporation into keratin sequences. Organic Preparations and Procedures International 35(4):375-382.


  • Egeghy PP, Nylander-French LA, Gwin KK, Hertz-Picciotto I, Rappaport SM. 2002. Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics. Annals of Occupational Hygiene 46(5):489-500.
  • Nam T, Sangaiah R, Gold A, Lacks GD, Nylander-French LA, French JE. 2002. Synthesis of FMOC-protected S-arylcysteines and modified keratin sequence peptides as specific epitopes as immunogens. Polycyclic Aromatic Compounds 22(3-4):239-248.


  • Nam T, Sangaiah R, Gold A, Lacks GD, Nylander-French LA, French JE. 2001. Synthesis of FMOC-protected S-aryclysteines and modified keratin sequence peptides as specific epitopes as immunogens. In: Proceedings of the 18th International Symposiium on Polycyclic Aromatic Compounds, Sept 9-13. Cincinnati, OH.
  • Nylander-French LA, Lacks GD, Mattorano DA. 2001. Quantification of naphthalene dermal exposure using non-invasive tape stripping of the stratum corneum, extraction, and normalization against keratin. Arbete och Halsa 10:23-24.


  • Nylander-French LA. 2000. A tape-stripping method for measuring dermal exposure to multifunctional acrylates. Annals of Occupational Hygiene 44:645-651.

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