Superfund Research Program

Leena A. Nylander-French

University of North Carolina-Chapel Hill
Department of Environmental Sciences and Engineering
CB #7431, 159 Rosenau Hall
Chapel Hill, North Carolina 27599-7431
Phone: 919-966-3826
Email: leena_french@unc.edu

Research Briefs

• 166 - Understanding Dermal Exposure - a Critical Step in Exposure Assessment

Publications

2019

• Meakin C, Martin EM, Szilagyi JT, Nylander-French LA, Fry RC. 2019. Inorganic Arsenic as an Endocrine Disruptor: Modulation of the Glucocorticoid Receptor Pathway in Placental Cells via CpG Methylation. Chem Res Toxicol 32(3):493-499. doi:10.1021/acs.chemrestox.8b00352 PMID:30746931

2012

• Jiang R, French JE, Stober V, Kang-Sickel JC, Zou F, Nylander-French LA. 2012. Single-nucleotide polymorphisms associated with skin naphthyl-keratin adduct levels in workers exposed to naphthalene. Environ Health Perspect 120:857-864. doi:10.1289/ehp.1104304 PMID:22391508 PMCID:PMC3385430

2011

• Kang-Sickel JC, Butler MA, Frame L, Serdar B, Chao YE, Egeghy PP, Rappaport SM, Toennis CA, Li W, Borisova T, French JE, Nylander-French LA. 2011. The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure. Biomarkers 16:590-599. doi:10.3109/1354750x.2011.611598 PMID:21961652 PMCID:PMC4174274

2010

• Kang-Sickel JC, Stober V, French JE, Nylander-French LA. 2010. Exposure to naphthalene induces naphthyl-keratin adducts in human epidermis in vitro and in vivo. Biomarkers 15:488-497. doi:10.3109/1354750x.2010.485700 PMID:20500019 PMCID:PMC2923669

2009

• Kim D, Nylander-French LA. 2009. Physiologically-Based Toxicokinetic Models and Their Application in Human Exposure and Internal Dose Assessment. In: Molecular, Clinical and Environmental Toxicology Volume 1. pp.470.

2008

• Chao YE, Zhao Y, Kupper LL, Nylander-French LA. 2008. Quantifying the relative importance of predictors in multiple linear regression analyses for public health studies. J Occup Environ Hyg 5(8):519-529. doi:10.1080/15459620802225481 PMID:18569519
• Kang-Sickel JC, Nam T, Jayaraj K, Ball LM, French JE, Klapper DG, Gold A, Nylander-French LA. 2008. S-arylcysteine-keratin adducts as biomarkers of human dermal exposure to aromatic hydrocarbons. Chem Res Toxicol 21(4):852-858. doi:10.1021/tx7003773 PMID:18361511
• Kim D, Farthing MW, Miller CT, Nylander-French LA. 2008. Mathematical description of the uptake of hydrocarbons in jet fuel into the stratum corneum of human volunteers. Toxicol Lett 178(3):146-151. doi:10.1016/j.toxlet.2008.03.005 PMID:18423910 PMCID:PMC2443700

2007

• Kim D, Andersen ME, Chao YE, Egeghy PP, Rappaport SM, Nylander-French LA. 2007. PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene. Environ Health Perspect 115(6):894-901. doi:10.1289/ehp.9778 PMID:17589597 PMCID:PMC1892111
• Kim D, Andersen ME, Chao YE, Egeghy PP, Rappaport SM, Nylander-French LA. 2007. Prediction of human dermal and inhalation exposures to jet fuel by analysis of a PBTK model. Environ Health Perspect 115(6):894-901.

2006

• Chao YE, Kupper LL, Serdar B, Egeghy PP, Rappaport SM, Nylander-French LA. 2006. Dermal exposure to jet fuel JP-8 significantly contributes to the production of urinary naphthols in fuel-cell maintenance workers. Environ Health Perspect 114(2):182-185. PMID:16451852 PMCID:PMC1367829
• Kang-Sickel JC, Gold A, Ball LM, Karupiah J, Nylander-French LA, Parron V, Klapper DG, French JE. 2006. Detection of naphthalene keratin adducts in human skin using ELISA. J Mol Biol 38(Suppl.2):67-68.
• Kim D, Andersen ME, Nylander-French LA. 2006. A dermatotoxicokinetic model of human exposures to jet fuel. Toxicol Sci 93(1):22-33. doi:10.1093/toxsci/kfl048 PMID:16801332
• Kim D, Andersen ME, Nylander-French LA. 2006. Dermal absorption and penetration of jet fuel components in humans. Toxicol Lett 165(1):11-21. doi:10.1016/j.toxlet.2006.01.009 PMID:16497449
• Serdar B, Tornero-Velez R, Echeverria D, Nylander-French LA, Kupper LL, Rappaport SM. 2006. Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industry. Occup Environ Med 63(10):707-12. PMID:16757507

2005

• Chao YE, Gibson RL, Nylander-French LA. 2005. Dermal exposure to jet fuel (JP-8) in US Air Force personnel. Ann Occup Hyg 49(7):639-645. PMID:16006502

2004

• Chao YE, Nylander-French LA. 2004. Determination of keratin protein in a tape-stripped skin sample from jet fuel exposed skin. Ann Occup Hyg 48(1):65-73. PMID:14718347
• Mattorano DA, Kupper LL, Nylander-French LA. 2004. Estimating dermal exposure to jet fuel (naphthalene) using adhesive tape strip samples. Ann Occup Hyg 48(2):139-146. PMID:14990435

2003

• Gold A, Nam T, Jayaraj K, Sangaiah R, Klapper DG, Ball LM, French JE, Nylander-French LA. 2003. Synthesis of S-aryl-D,L-cysteines and incorporation into keratin sequences. Organic Preparations and Procedures International 35(4):375-382.

2002

• Egeghy PP, Nylander-French LA, Gwin KK, Hertz-Picciotto I, Rappaport SM. 2002. Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics. Ann Occup Hyg 46(5):489-500. PMID:12176763
• Nam T, Sangaiah R, Gold A, Lacks GD, Nylander-French LA, French JE. 2002. Synthesis of FMOC-protected S-arylcysteines and modified keratin sequence peptides as specific epitopes as immunogens. Polycyclic Aromatic Compounds 22(3-4):239-248.

2001

• Nam T, Sangaiah R, Gold A, Lacks GD, Nylander-French LA, French JE. 2001. Synthesis of FMOC-protected S-aryclysteines and modified keratin sequence peptides as specific epitopes as immunogens. In: Proceedings of the 18^th International Symposiium on Polycyclic Aromatic Compounds, Sept 9-13. Cincinnati, OH.
• Nylander-French LA, Lacks GD, Mattorano DA. 2001. Quantification of naphthalene dermal exposure using non-invasive tape stripping of the stratum corneum, extraction, and normalization against keratin. Arbete och Halsa 10:23-24.

2000

• Nylander-French LA. 2000. A tape-stripping method for measuring dermal exposure to multifunctional acrylates. Ann Occup Hyg 44:645-651. PMID:11108786