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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: David E. Williams

Superfund Research Program

David E. Williams

Oregon State University
Department of Environmental and Molecular Toxicology
473 Linus Pauling Sciences Center
Corvallis, Oregon 97331
Phone: 541-737-3277
Fax: 541-737-7966
Email: david.williams@oregonstate.edu

Projects

Publications

2023

  • Maier ML, Siddens LK, Pennington JM, Uesugi S, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or brussels sprouts. Toxicol Appl Pharmacol 460:116377. doi:10.1016/j.taap.2023.116377 PMID:36642108 PMCID:PMC9946811
  • Vermillion Maier ML, Siddens LK, Pennington J, Uesugi S, Labut EM, Vertel EA, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing. Chem Biol Interact 382:110608. doi:10.1016/j.cbi.2023.110608

2022

  • Pande P, Madeen E, Williams DE, Crowell SR, Ognibene T, Turteltaub KW, Corley RA, Smith JN. 2022. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 438:doi:10.1016/j.taap.2021.115830 PMID:34933053 PMCID:PMC9264404
  • Vermillion Maier ML, Siddens LK, Pennington JM, Uesugi S, Anderson KA, Tidwell LG, Tilton SC, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2022. Benzo a pyrene (BaP) metabolites predominant in human plasma following escalating oral micro-dosing with C-14 -BaP. Environ Int 159:doi:10.1016/j.envint.2021.107045 PMID:34920278 PMCID:PMC8791557

2021

  • Vermillion Maier ML, Siddens LK, Uesugi S, Choi J, Leonard SW, Pennington J, Tilton SC, Smith JN, Ho E, Chow S, Nguyen BD, Kolluri SK, Williams DE. 2021. 3,3'-diindolylmethane (BioResponse DIM) exhibits significant metabolism following oral dosing in humans. Drug Metab Dispos 49(8):doi:10.1124/dmd.120.000346 PMID:34035125 PMCID:PMC8407664 (ahead of print)

2019

  • Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub KW, Williams DE. 2019. Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 364:97-105. doi:10.1016/j.taap.2018.12.010 PMID:30582946 PMCID:PMC6369707

2018

  • Hummel JM, Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Anderson KA, Turteltaub KW, Ognibene T, Bench G, Krueger SK, Harris S, Smith JN, Tilton SC, Baird WM, Williams DE. 2018. Pharmacokinetics of [(14)C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol 115:136-147. doi:10.1016/j.fct.2018.03.003 PMID:29518434 PMCID:PMC5935529

2017

  • Madeen E, Lohr CV, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer LM, Waters KM, Williams DE, You H. 2017. Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog 56(1):163-171. doi:10.1002/mc.22480 PMID:26990437

2016

  • Madeen E, Ognibene T, Corley RA, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE, McQuistan TJ. 2016. Human microdosing with carcinogenic polycyclic aromatic hydrocarbons: in vivo pharmacokinetics of dibenzo[def,p]chrysene and metabolites by UPLC accelerator mass spectrometry. Chem Res Toxicol 29(10):1641-1650. doi:10.1021/acs.chemrestox.6b00169 PMID:27494294 PMCID:PMC5380438
  • Madeen E, Williams DE. 2016. Environmental PAH exposure and male idiopathic infertility: a review on early life exposures and adult diagnosis. Rev Environ Health 23(1-2):73-81. doi:10.1515/reveh-2016-0045 PMID:27935856 PMCID:PMC5454023
  • Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Harding A, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Expanding on successful concepts, models, and organization. Environ Sci Technol 50(17):8921-8922. doi:10.1021/acs.est.6b03027 PMID:27509267
  • Teeguarden J, Tan Y, Edwards SW, Leonard JA, Anderson KA, Corley RA, Kile ML, Simonich SL, Stone D, Tanguay RL, Waters KM, Harper SL, Williams DE. 2016. Completing the link between exposure science and toxicology for improved environmental health decision making: the aggregate exposure pathway framework. Environ Sci Technol 50(9):4579-4586. doi:10.1021/acs.est.5b05311 PMID:26759916 PMCID:PMC4854780

2015

  • Harper TA, Morre JT, Lauer FT, McQuistan TJ, Hummel JM, Burchiel SW, Williams DE. 2015. Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS. Mutat Res 782:51-56. doi:10.1016/j.mrgentox.2015.03.007 PMID:25868132 PMCID:PMC4395865
  • Larkin A, Williams DE, Kile ML, Baird WM. 2015. Developing a smartphone software package for predicting atmospheric pollutant concentrations at mobile locations. Comput J 58(6):1431-1442. doi:10.1093/comjnl/bxu067 PMID:26146409 PMCID:PMC4489712
  • Madeen E, Corley RA, Crowell SR, Turteltaub KW, Ognibene T, Malfatti MA, McQuistan TJ, Garrard M, Sudakin D, Williams DE. 2015. Human in vivo pharmacokinetics of [(14)C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing. Chem Res Toxicol 28(1):126-134. doi:10.1021/tx5003996 PMID:25418912 PMCID:PMC4303324
  • Siddens LK, Bunde KL, Harper TA, McQuistan TJ, Lohr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM. 2015. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol 287(2):149-160. doi:10.1016/j.taap.2015.05.019 PMID:26049101 PMCID:PMC4689210
  • Tilton SC, Siddens LK, Krueger SK, Larkin A, Lohr CV, Williams DE, Baird WM, Waters KM. 2015. Mechanism-based classification of PAH mixtures to predict carcinogenic potential. Toxicol Sci 146(1):135-145. doi:10.1093/toxsci/kfv080 PMID:25908611 PMCID:PMC4476464

2013

  • Crowell SR, Sharma AK, Amin S, Soelberg JJ, Sadler NC, Wright AT, Baird WM, Williams DE, Corley RA. 2013. Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. Toxicol Sci 135(1):48-62. doi:10.1093/toxsci/kft124 PMID:23744095 PMCID:PMC3748759
  • Larkin A, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, Baird WM. 2013. Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol 267(2):192-199. doi:10.1016/j.taap.2012.12.011 PMID:23274566 PMCID:PMC3626406

2012

  • Benninghoff AD, Orner GA, Buchner CH, Hendricks JD, Duffy AM, Williams DE. 2012. Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. Toxicol Sci 125(1):69-78. doi:10.1093/toxsci/kfr267 PMID:21984479 PMCID:PMC3243748
  • Shorey LE, Castro DJ, Baird WM, Siddens LK, Lohr CV, Matzke MM, Waters KM, Corley RA, Williams DE. 2012. Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring. Cancer Lett 317(1):49-55. doi:10.1016/j.canlet.2011.11.010 PMID:22085489 PMCID:PMC3269513
  • Siddens LK, Larkin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Lohr CV, Arlt VM, Phillips DH, Williams DE, Baird WM. 2012. Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 264(3):377-386. doi:10.1016/j.taap.2012.08.014 PMID:22935520 PMCID:PMC3483092

2011

  • Crowell SR, Amin S, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, Williams DE, Corley RA. 2011. Preliminary physiologically based pharmacokinetic models for benzo a pyrene and dibenzo def,p chrysene in rodents. Toxicol Appl Pharmacol 257:365-376. doi:10.1016/j.taap.2011.09.020 PMID:22001385 PMCID:PMC3226888
  • Larkin A, Siddens LK, Krueger SK, Baird WM, Williams DE. 2011. Developing a fuzzy neural network model for predicting the interactive effects of complex PAH mixtures on the CYP1B1 transcriptional regulatory network. In: Superfund Research Program Annual Meeting Oct. 24-25. Lexington, KY.
  • Madeen EP, Larkin A, Siddens LK, Krueger SK, Lohr CV, Anderson KA, Simonich SL, Williams DE, Baird WM. 2011. Transplacental exposure to individual environmental carcinogens or mixtures, and dietary intervention as a chemoprevention strategy. In: Superfund Research Program Annual Meeting Oct. 24-25. Lexington, KY.

2010

  • Larkin A, Siddens LK, Krueger SK, Madeen EP, Williams DE, Baird WM. 2010. Gene expression profiling in the skin of FVB/N mice treated with environmental PAH mixtures. Environ Mol Mutagen 51(7):735. doi:10.1002/em.20625
  • Siddens LK, Castro DJ, Larkin A, Simonich SL, Arlt VM, Phillips DH, Löhr C, Krueger SK, Williams DE, Baird WM, Swanson HI. 2010. Skin and transplacental carcinogenesis in mice following application of individual polycyclic aromatic hydrocarbons (PAHs) and environmental mixtures. In: Biological Radical Intermediates VIII Proceedings. Barcelona, Spain.

2003

  • Williams DE, Bailey GS, Reddy A, Hendricks JD, Oganesian A, Orner GA, Pereira CB, Swenberg JA. 2003. The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters. Toxicol Pathol 31(Suppl.1):58-61. PMID:12597433
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