Superfund Research Program

A. Brent Carter

University of Alabama at Birmingham
Division of Pulmonary, Allergy and Critical Care Medicine
421 THT
Charles A. McCallum Basic Health Sciences Education and Research Building
Birmingham, Alabama 35294-0006
Phone: 205-934-1682
Email: bcarter1@uab.edu

Projects

• University of Alabama at Birmingham: Heavy Metals Exacerbate Lower Respiratory Tract Infections (2020-2025)

Research Briefs

• 343 - Cadmium-Linked Inflammation Increases the Severity of Lung Infection

Publications

2023

• Guo T, Jiang C, Yang S, Zhu Y, He C, Carter AB, Antony V, Peng H, Zhou Y. 2023. Mitochondrial fission and bioenergetics mediate human lung fibroblast durotaxis. JCI Insight 8(1):doi:10.1172/jci.insight.157348 PMID:36422990 PMCID:9870082
• Larson-Casey JL, Liu S, Pyles JM, Lapi SE, Saleem K, Antony V, Gonzalez ML, Crossman DK, Carter AB. 2023. Impaired PPARy activation by cadmium exacerbates infection-induced lung injury. JCI Insight 8(9):e166608. doi:10.1172/jci.insight.166608 PMID:36928191 PMCID:PMC10243824
• Larson-Casey JL, Saleem K, Surolia R, Pandey J, Mack M, Antony V, Bodduluri S, Bhatt S, Duncan SR, Carter AB. 2023. Myeloid heterogeneity mediates acute exacerbations of pulmonary fibrosis. J Immunol 211(11):1714-1724. doi:10.4049/jimmunol.2300053 PMID:37782053
• Pandey J, Larson-Casey JL, Patil MH, Joshi R, Jiang C, Zhou Y, He C, Carter AB. 2023. NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming. J Biol Chem 299(5):104695. doi:10.1016/j.jbc.2023.104695 PMID:37044213 PMCID:PMC10193017

2022

• He C, Carter AB. 2022. CRTH2 in pulmonary fibrosis: Friend or foe?. Am J Respir Cell Mol Biol 67(2):145-146. doi:10.1165/rcmb.2022-0232ED PMID:35675551 PMCID:PMC9348569
• Larson-Casey JL, Carter AB. 2022. Does UCP2 couple hyperoxia to lung injury?. Am J Respir Cell Mol Biol 66(3):250-251. doi:10.1165/rcmb.2021-0480ED PMID:34905723 PMCID:PMC8937246

2021

• Gu L, Surolia R, Larson-Casey JL, He C, Davis D, Kang J, Antony V, Carter AB. 2021. Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling. Cell Death Differ 29(1):doi:10.1038/s41418-021-00840-w PMID:34413485 (ahead of print)
• Larson-Casey JL, Gu L, Davis D, Cai G, Ding Q, He C, Carter AB. 2021. Post-translational regulation of PGC-1(alpha) modulates fibrotic repair. FASEB J 35:e21675. doi:10.1096/fj.202100339R PMID:34038004 PMCID:PMC8252570
• Larson-Casey JL, Gu L, Kang J, Dhyani A, Carter AB. 2021. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. J Biol Chem 297:12. doi:10.1016/j.jbc.2021.100810 PMID:34023385 PMCID:PMC8214193
• Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AV, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal V, Carter AB, Antony V. 2021. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med 13(585):doi:10.1126/scitranslmed.aba2927 PMID:33731433

2020

• Larson-Casey JL, Gu L, Fiehn O, Carter AB. 2020. Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages. J Biol Chem 295:15754-15766. doi:10.1074/jbc.RA120.013632 PMID:32917723 PMCID:PMC7667973
• Larson-Casey JL, He C, Che P, Wang M, Cai G, Kim Y, El Hamdaoui M, Grytz R, Dong Q, Carter AB. 2020. Technical advance: the use of tree shrews as a model of pulmonary fibrosis. PLoS One 15(11):e0241323. doi:10.1371/journal.pone.0241323 PMID:33141839 PMCID:PMC7608928

2019

• Larson-Casey JL, Vaid M, Gu L, He C, Cai G, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini AF, Hanumanthu VS, Surolia R, Antony V, Carter AB. 2019. Increased flux through the mevalonate pathway mediates fibrotic repair without injury. J Clin Invest 129:4962-4978. doi:10.1172/JCI127959 PMID:31609245 PMCID:PMC6819144