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Your Environment. Your Health.

Person Details: Mario Medvedovic

Superfund Research Program

Mario Medvedovic

University of Cincinnati Medical Center
Department of Environmental Health
PO Box 670056
Cincinnati, Ohio 45267-0056
Phone: 513-558-8564
Fax: 513-558-4838




  • Sartor MA, Tomlinson CR, Wesselkamper SC, Sivaganesan S, Medvedovic M, Leikauf GD. 2006. Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments. BMC Bioinformatics 7:538. doi:10.1186/1471-2105-7-538 PMID:17177995 PMCID:PMC1781470
  • Sartor MA, Zorn AM, Schwanekamp J, Halbleib D, Karyala S, Howell ML, Dean GE, Medvedovic M, Tomlinson CR. 2006. A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus. Nucleic Acids Res 34(1):185-200. doi:10.1093/nar/gkj413 PMID:16397297 PMCID:PMC1325202
  • Schwanekamp J, Sartor MA, Karyala S, Halbleib D, Medvedovic M, Tomlinson CR. 2006. Genome-wide analyses show that nuclear and cytoplasmic RNA levels are differentially affected by dioxin. Biochim Biophys Acta 1759(8-9):388-402. doi:10.1016/j.bbaexp.2006.07.005 PMID:16962184
  • Wesselkamper SC, McDowell SA, Medvedovic M, Dalton TP, Deshmukh HS, Sartor MA, Case LM, Henning LN, Borchers MT, Tomlinson CR, Prows DR, Leikauf GD. 2006. The role of metallothionein in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol 34(1):73-82. doi:10.1165/rcmb.2005-0248OC PMID:16166738 PMCID:PMC2644192



  • Bahassi E, Karyala S, Tomlinson CR, Sartor MA, Medvedovic M, Hennigan RF. 2004. Critical regulation of genes for tumor cell migration by AP-1. Clin Exp Metastasis 21(4):293-304. PMID:15554385
  • Guo J, Sartor MA, Karyala S, Medvedovic M, Kann S, Puga A, Ryan P, Tomlinson CR. 2004. Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicol Appl Pharmacol 194(1):79-89. PMID:14728982
  • Karyala S, Guo J, Sartor MA, Medvedovic M, Puga A, Ryan P, Tomlinson CR. 2004. Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice. Cardiovasc Toxicol 4(1):47-73. PMID:15034205
  • Medvedovic M, Yeung KY, Bumgarner RE. 2004. Bayesian mixture model based clustering of replicated microarray data. Bioinformatics 20(8):1222-1232. PMID:14871871
  • Puga A, Sartor MA, Huang M, Kerzee JK, Wei Y, Tomlinson CR, Baxter CS, Medvedovic M. 2004. Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure. Cardiovasc Toxicol 4(4):385-404. PMID:15531781
  • Sartor MA, Schwanekamp J, Halbleib D, Mohamed I, Karyala S, Medvedovic M, Tomlinson CR. 2004. Microarray results improve significantly as hybridization approaches equilibrium. Biotechniques 36(5):790-796. PMID:15152598
  • Sonntag DM, de Boer J, Medvedovic M, Baxter CS, LeMasters G, Talaska G. 2004. Mutational biases associated with potential iron-binding DNA motifs in rodent lacI and human p53 mutational databases. Mutat Res 550(1-2):73-88. doi:10.1016/j.mrfmmm.2004.02.004 PMID:15135642
  • Vineis P, Schulte PA, Carreon T, Bailer AJ, Medvedovic M. 2004. Issues of design and analysis in studies of gene-environment interactions. IARC Sci Publ (157):417-435. PMID:15055309
  • Yeung KY, Medvedovic M, Bumgarner RE. 2004. From co-expression to co-regulation: how many microarray experiments do we need?. Genome Biol Evol 5(7):R48. doi:10.1186/gb-2004-5-7-r48 PMID:15239833 PMCID:PMC463312
  • Zhang J, Moseley A, Jegga AG, Gupta A, Witte DP, Sartor MA, Medvedovic M, Williams SS, Ley-Ebert C, Coolen LM, Egnaczyk G, Genter M, Lehman M, Lingrel J, Maggio J, Parysek L, Walsh R, Xu M, Aronow BJ. 2004. Neural system-enriched gene expression: relationship to biological pathways and neurological diseases. Physiol Genomics 18(2):167-183. doi:10.1152/physiolgenomics.00220.2003 PMID:15126645


  • Tsuneoka Y, Dalton TP, Miller ML, Clay CD, Shertzer HG, Talaska G, Medvedovic M, Nebert DW. 2003. 4-Aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice. J Natl Cancer Inst 95(16):1227-1237. doi:10.1093/jnci/djg025 PMID:12928348
  • Yeung KY, Medvedovic M, Bumgarner RE. 2003. Clustering gene-expression data with repeated measurements. Genome Biol Evol 4(5):R34. PMID:12734014 PMCID:PMC156590


  • Medvedovic M, Sivaganesan S. 2002. Bayesian infinite mixture model based clustering of gene expression profiles. Bioinformatics 18(9):1194-1206. PMID:12217911


  • Medvedovic M, Succop P, Dixon K, Shukla R. 2001. Clustering mutational spectra via classification and MCMC algorithms. J Agric Biol Environ Stat 6(1):19-37.


  • Liu S, Medvedovic M, Dixon K. 1999. Mutational specificity in a shuttle vector replicating in chromium(VI)-treated mammalian cells. Environ Mol Mutagen 33(4):313-319. PMID:10398379
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