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Person Details: Ivan Rusyn

Superfund Research Program

Ivan Rusyn

Texas A&M University
273 VRBA
College Station, Texas 77843-4458
Phone: 979-458-9866


Research Briefs

Hazardous Waste Sites

French, Ltd.

  • Texas A&M University: Inter-Tissue and -Individual Variability in Response to Mixtures

Houston Ship Channel/Galveston Bay

  • Texas A&M University: Inter-Tissue and -Individual Variability in Response to Mixtures



  • Ford L, Lin H, Tsai H, Zhou Y, Wright FA, Sedykh A, Shah R, Chiu WA, Rusyn I. 2024. Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types. Toxicology 503:153763. doi:10.1016/j.tox.2024.153763 PMID:38423244
  • Lin H, Rusyn I, Chiu WA. 2024. Assessing proarrhythmic potential of environmental chemicals using a high throughput in vitro-in silico model with human induced pluripotent stem cell-derived cardiomyocytes. ALTEX 41(1):37-49. doi:10.14573/altex.2306231 PMID:37921411
  • Lu E, Ford L, Chen Z, Burnett SD, Rusyn I, Chiu WA. 2024. Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure. Regul Toxicol Pharmacol 148:105596. doi:10.1016/j.yrtph.2024.105596 PMID:38447894
  • Tsai H, Ford L, Chen Z, Dickey AN, Wright FA, Rusyn I. 2024. Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes. ALTEX doi:10.14573/altex.2311031 PMID:38429992
  • Vidal MS, Richardson L, Kumar Kammala A, Kim S, Lam P, Cherukuri R, Thomas T, Bettayeb M, Han A, Rusyn I, Menon R. 2024. Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies. Lab Chip doi:10.1039/d3lc00998j PMID:38334486


  • Anderson MJ, Valdiviezo A, Conway MH, Farrell C, Andringa RK, Janik A, Chiu WA, Rusyn I, Hamer SA. 2023. Imidacloprid exposure is detectable in over one third of wild bird samples from diverse Texas ecoregions. Sci Total Environ 876:162723. doi:10.1016/j.scitotenv.2023.162723 PMID:36907393
  • Cordova AC, Dodds J, Tsai H, Lloyd D, Roman-Hubers AT, Wright FA, Chiu WA, McDonald TJ, Zhu R, Newman G, Rusyn I. 2023. Application of ion mobility spectrometry-mass spectrometry for compositional characterization and fingerprinting of a library of diverse crude oil samples. Environ Toxicol Chem doi:10.1002/etc.5727 PMID:37530422
  • Cordova AC, Ford L, Valdiviezo A, Roman-Hubers AT, McDonald TJ, Chiu WA, Rusyn I. 2023. Dosing methods to enable cell-based in vitro testing of complex substances: a case study with a PAH mixture. Toxics 11(1):19. doi:10.3390/toxics11010019 PMID:36668745 PMCID:PMC9866728
  • Cordova AC, Klaren WD, Ford L, Grimm FA, Baker ES, Zhou Y, Wright FA, Rusyn I. 2023. Integrative chemical-biological grouping of complex high production volume substances from lower olefin manufacturing streams. Toxics 11(7):586. doi:10.3390/toxics11070586 PMID:37505552 PMCID:PMC10385386
  • Cuomo D, Nitcher M, Barba E, Feinberg AP, Rusyn I, Chiu WA, Threadgill DW. 2023. Refining risk estimates for lead in drinking water based on the impact of genetics and diet on blood lead levels using the Collaborative Cross mouse population. Toxicol Sci doi:10.1093/toxsci/kfad054 PMID:37243727 PMCID:PMC10375319
  • Lim AY, Kato Y, Sakolish C, Valdiviezo A, Han G, Bajaj P, Stanko JP, Ferguson SS, Villenave R, Hewitt P, Hardwick RN, Rusyn I. 2023. Reproducibility and robustness of a liver microphysiological system PhysioMimix LC12 under varying culture conditions and cell type combinations. Bioengineering 10(10):doi:10.3390/bioengineering10101195 PMID:37892925 PMCID:10603899
  • Lu E, Grimm FA, Rusyn I, Saeger SD, De Boevre M, Chiu WA. 2023. Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol. Environ Int 182:108326. doi:10.1016/j.envint.2023.108326 PMID:38000237
  • Oladeji O, Saitas M, Mustapha T, Johnson N, Chiu WA, Rusyn I, Robinson AL, Presto AA. 2023. Air pollutant patterns and human health risk following the East Palestine, Ohio, train derailment. Environ Sci Technol Lett 10(8):680-685. doi:10.1021/acs.estlett.3c00324 PMID:37577363 PMCID:PMC10413936
  • Rusyn I, Wright FA. 2023. Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations. Toxicol Sci doi:10.1093/toxsci/kfad134 PMID:38141214
  • Sakolish C, Moyer HL, Tsai H, Ford L, Dickey AN, Wright FA, Han G, Bajaj P, Baltazar MT, Carmichael PL, Stanko JP, Ferguson SS, Rusyn I. 2023. Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity. Toxicol Sci doi:10.1093/toxsci/kfad080 PMID:37555834
  • Tsai H, House JS, Wright FA, Chiu WA, Rusyn I. 2023. A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo. Toxicol Sci doi:10.1093/toxsci/kfad041 PMID:37079747 PMCID:PMC10230285


  • Aeppli C, Mitchell DA, Keyes P, Beirne EC, McFarlin KM, Roman-Hubers AT, Rusyn I, Prince RC, Zhao L, Parkerton TF, Nedwed T. 2022. Oil irradiation experiments document changes in oil properties, molecular composition, and dispersant effectiveness associated with oil photo-oxidation. Environ Sci Technol 56:doi:10.1021/acs.est.1c06149 PMID:35605020
  • Bhandari S, Casillas GA, Aly NA, Zhu R, Newman G, Wright FA, Miller A, Adler G, Rusyn I, Chiu WA. 2022. Spatial and temporal analysis of impacts of Hurricane Florence on criteria air pollutants and air toxics in eastern North Carolina. Int J Environ Res Public Health 19(3):doi:10.3390/ijerph19031757 PMID:35162780 PMCID:PMC8835244
  • Blanchette A, Burnett SD, Rusyn I, Chiu WA. 2022. A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability. J Pharmacol Toxicol Methods 114:doi:10.1016/j.vascn.2022.107154 PMID:34999233 PMCID:PMC8930538
  • Boysen G, Rusyn I, Chiu WA, Wright FA. 2022. Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice. Regul Toxicol Pharmacol doi:10.1016/j.yrtph.2022.105171 PMID:35469930
  • Ford L, Jang S, Chen Z, Zhou Y, Gallins P, Wright FA, Chiu WA, Rusyn I. 2022. A population-based human in vitro approach to quantify inter-individual variability in responses to chemical mixtures. Toxics 10(8):441. doi:10.3390/toxics10080441 PMID:36006120
  • House JS, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogard PJ, Ketelslegers HB, Gant TW, Rusyn I, Wright FA, Grimm FA, Klaren WD. 2022. Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays. ALTEX doi:10.14573/altex.2107051 PMID:35288757
  • Jang S, Ford L, Rusyn I, Chiu WA. 2022. Cumulative risk meets inter-individual variability: probabilistic concentration addition of complex mixture exposures in a population-based human in vitro model. Toxics 10(10):549. doi:10.3390/toxics10100549 PMID:36287830 PMCID:PMC9611413
  • Kato Y, Lim AY, Sakolish C, Valdiviezo A, Moyer HL, Hewitt P, Bajaj P, Han G, Rusyn I. 2022. Analysis of reproducibility and robustness of OrganoPlate 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs. Toxicol Vitro doi:10.1016/j.tiv.2022.105464 PMID:36057418 PMCID:PMC10015056
  • Kowalczewski A, Sakolish C, Hoang P, Liu X, Jacquir S, Rusyn I, Ma Z. 2022. Integrating nonlinear analysis and machine learning for human induced pluripotent stem cell-based drug cardiotoxicity testing. J Tissue Eng Regen Med doi:10.1002/term.3325 PMID:35621199
  • Roman-Hubers AT, Aeppli C, Dodds J, Baker ES, McFarlin KM, Letinski DJ, Zhao L, Mitchell DA, Parkerton TF, Prince RC, Nedwed T, Rusyn I. 2022. Temporal chemical composition changes in water below a crude oil slick irradiated with natural sunlight. Mar Pollut Bull 185:114360. doi:10.1016/j.marpolbul.2022.114360 PMID:36413931
  • Roman-Hubers AT, Cordova AC, Rohde A, Chiu WA, McDonald TJ, Wright FA, Dodds J, Baker ES, Rusyn I. 2022. Characterization of compositional variability in petroleum substances. Fuel 317:doi:10.1016/j.fuel.2022.123547 PMID:35250041 PMCID:PMC8896784
  • Rusyn I, Chiu WA. 2022. Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data. Toxicol Sci doi:10.1093/toxsci/kfac033 PMID:35404442
  • Rusyn I, Chiu WA, Wright FA. 2022. Model systems and organisms for addressing inter- and intra-species variability in risk assessment. Regul Toxicol Pharmacol 132:105197. doi:10.1016/j.yrtph.2022.105197 PMID:35636685
  • Sakolish C, Georgescu A, Huh DD, Rusyn I. 2022. A model of human small airway on a chip for studies of subacute effects of inhalation toxicants. Toxicol Sci 187(2):267-278. doi:10.1093/toxsci/kfac036 PMID:35357501
  • Valdiviezo A, Brown GE, Michell AR, Trinconi CM, Bodke VV, Khetani SR, Luo Y, Chiu WA, Rusyn I. 2022. Reanalysis of trichloroethylene and tetrachloroethylene metabolism to glutathione conjugates using human, rat, and mouse liver in vitro models to improve precision in risk characterization. Environ Health Perspect 130(11):117009. doi:10.1289/EHP12006 PMID:36445294 PMCID:PMC9707501
  • Valdiviezo A, Kato Y, Baker ES, Chiu WA, Rusyn I. 2022. Evaluation of metabolism of a defined pesticide mixture through multiple in vitro liver models. Toxics 10(10):566. doi:10.3390/toxics10100566 PMID:36287846 PMCID:PMC9609317


  • Alves VM, Auerbach SS, Kleinstreuer N, Rooney JP, Muratov EN, Rusyn I, Tropsha A, Schmitt CJ. 2021. Curated data in - trustworthy in silico models out: The impact of data quality on the reliability of artificial intelligence models as alternatives to animal testing. Altern Lab Anim 49(3):doi:10.1177/02611929211029635 PMID:34233495 (ahead of print)
  • Aly NA, Dodds J, Luo Y, Grimm FA, Foster MR, Rusyn I, Baker ES. 2021. Utilizing ion mobility spectrometry-mass spectrometry for the characterization and detection of persistent organic pollutants and their metabolites. Anal Bioanal Chem 414(3):doi:10.1007/s00216-021-03686-w PMID:34668045 (ahead of print)
  • Anklam E, Bahl MI, Ball R, Beger RD, Cohen J, Fitzpatrick S, Girard P, Halamoda-Kenzaoui B, Hinton D, Hirose A, Hoeveler A, Honma M, Hugas M, Ishida S, Kass GE, Kojima H, Krefting I, Liachenko S, Liu Y, Masters S, Marx U, McCarthy T, Mercer T, Patri A, Pelaez C, Pirmohamed M, Platz S, Ribeiro AJ, Rodricks JV, Rusyn I, Salek RM, Schoonjans R, Silva P, Svendsen CN, Sumner S, Sung K, Tagle DA, Tong L, Tong W, Van den Eijnden-van Raaij J, Vary N, Wang T, Waterton J, Wang M, Wen H, Wishart D, Yuan Y, Slikker W. 2021. Emerging technologies and their impact on regulatory science. Exp Biol Med (Maywood) 75:doi:10.1177/15353702211052280 PMID:34783606
  • Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Cardiotoxicity hazard and risk characterization of ToxCast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors. Chem Res Toxicol 34(9):2110-2124. doi:10.1021/acs.chemrestox.1c00203 PMID:34448577
  • Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: Strengths and weaknesses for hazard identification and risk characterization. Expert Opin Drug Metab Toxicol 17(8):1-16. doi:10.1080/17425255.2021.1894122 PMID:33612039 (ahead of print)
  • Burnett SD, Karmakar M, Murphy WJ, Chiu WA, Rusyn I. 2021. A new approach method for characterizing inter-species toxicodynamic variability. J Toxicol Environ Health A 84(24):doi:10.1080/15287394.2021.1966861 PMID:34427174 (ahead of print)
  • Chen Z, Jang S, Kaihatu JM, Zhou Y, Wright FA, Chiu WA, Rusyn I. 2021. Potential human health hazard of post-Hurricane Harvey sediments in Galveston Bay and Houston Ship Channel: A case study of using in vitro bioactivity data to inform risk management decisions. Int J Environ Res Public Health 18:doi:10.3390/ijerph182413378 PMID:34948986 PMCID:PMC8702027
  • Chen Z, Lloyd D, Zhou Y, Chiu WA, Wright FA, Rusyn I. 2021. Risk characterization of environmental samples using in vitro bioactivity and polycyclic aromatic hydrocarbon (PAH) concentrations data. Toxicol Sci 179(1):108-120. doi:10.1093/toxsci/kfaa166 PMID:33165562 PMCID:PMC7797768
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2021. Quantitative characterization of population-wide tissue- and metabolite-specific variability in perchloroethylene toxicokinetics in male mice. Toxicol Sci 182(2):doi:10.1093/toxsci/kfab057 PMID:33988684 (ahead of print)
  • Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova N, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383. doi:10.1021/acs.chemrestox.1c00291 PMID:34726909 PMCID:PMC8715497
  • House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, Ketelslegers HB, Gant TW, Wright FA, Rusyn I. 2021. Grouping of UVCB substances with new approach methodologies (NAMs) data. ALTEX 38:123-137. doi:10.14573/altex.2006262 PMID:33086383 PMCID:PMC7900923
  • Hsieh N, Chen Z, Rusyn I, Chiu WA. 2021. Risk Characterization and Probabilistic Concentration Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays. Environ Health Perspect 129:doi:10.1289/EHP7600 PMID:33395322 PMCID:PMC7781439
  • Jang S, McDonald TJ, Bhandari S, Rusyn I, Chiu WA. 2021. Spatial and temporal distribution of surface water contaminants in the Houston Ship Channel after the Intercontinental Terminal Company Fire. J Expo Sci Environ Epidemiol 31(5):doi:10.1038/s41370-021-00343-3 PMID:34079063 (ahead of print)
  • Kim S, Richardson L, Radnaa E, Chen Z, Rusyn I, Menon R, Han A. 2021. Molecular mechanisms of environmental toxin cadmium at the feto-maternal interface investigated using an organ-on-chip (FMi-OOC) model. J Hazard Mater 422:126759. doi:10.1016/j.jhazmat.2021.126759 PMID:34391970 (ahead of print)
  • Luo Y, Chen Z, Blanchette A, Zhou Y, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Food Chem Toxicol doi:10.1016/j.fct.2021.111979 PMID:33450301
  • Marvel S, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. Environ Health Perspect 129:17701. doi:10.1289/EHP8690 PMID:33400596 PMCID:PMC7785295
  • Roman-Hubers AT, Cordova AC, Aly NA, McDonald TJ, Lloyd D, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Data processing workflow to identify structurally related compounds in petroleum substances using ion mobility spectrometry-mass spectrometry. Energy Fuels 35:10529-10539. doi:10.1021/acs.energyfuels.1c00892 PMID:34366560 PMCID:PMC8341389
  • Roman-Hubers AT, McDonald TJ, Baker ES, Chiu WA, Rusyn I. 2021. A comparative analysis of analytical techniques for rapid oil spill identification. Environ Toxicol Chem 40(4):1034-1049. doi:10.1002/etc.4961 PMID:33315271 PMCID:PMC8104454
  • Rusyn I, Arzuaga X, Cattley RC, Corton JC, Ferguson SS, Godoy P, Guyton KZ, Kaplowitz N, Khetani SR, Roberts RA, Roth RA, Smith MT. 2021. Key characteristics of human hepatotoxicants as a basis for identification and characterization of the causes of liver toxicity. Hepatology 74(6):doi:10.1002/hep.31999 PMID:34105804 (ahead of print)
  • Sakolish C, Luo Y, Chiu WA, Rusyn I, Reese CE, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Vernetti LA. 2021. Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). Toxicology 448:doi:10.1016/j.tox.2020.152651 PMID:33307106 PMCID:PMC7785655
  • Sakolish C, Luo Y, Valdiviezo A, Vernetti LA, Rusyn I, Chiu WA. 2021. Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. Toxicology 463:152954. doi:10.1016/j.tox.2021.152954 PMID:34543702 PMCID:PMC8585690
  • Valdiviezo A, Aly NA, Luo Y, Cordova AC, Casillas GA, Foster MR, Baker ES, Rusyn I. 2021. Analysis of per- and polyfluoroalkyl substances in Houston Ship Channel and Galveston Bay following a large-scale industrial fire using ion-mobility-spectrometry-mass spectrometry. J Environ Sci (China) 115:350-362. doi:10.1016/j.jes.2021.08.004 PMID:34969462 PMCID:PMC8724578
  • Valdiviezo A, Luo Y, Chen Z, Chiu WA, Rusyn I. 2021. Quantitative in vitro-to-in vivo extrapolation for mixtures: A case study of Superfund priority list pesticides. Toxicol Sci 183(1):doi:10.1093/toxsci/kfab076 PMID:34142158 (ahead of print)
  • Wang M, Chen Z, Rusyn I, Phillips TD. 2021. Testing the efficacy of broad-acting sorbents for environmental mixtures using isothermal analysis, mammalian cells, and H. vulgaris. J Hazard Mater 408:124425. doi:10.1016/j.jhazmat.2020.124425 PMID:33162237 PMCID:PMC7904642


  • Aly NA, Luo Y, Liu Y, Casillas GA, McDonald TJ, Kaihatu JM, Jun M, Ellis N, Gossett S, Dodds J, Baker ES, Bhandari S, Chiu WA, Rusyn I. 2020. Temporal and spatial analysis of per and polyfluoroalkyl substances in surface waters of Houston ship channel following a large-scale industrial fire incident. Environ Pollut 265:115009. doi:10.1016/j.envpol.2020.115009 PMID:32574947 PMCID:PMC7857671
  • Blanchette A, Burnett SD, Grimm FA, Rusyn I, Chiu WA. 2020. A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model. Toxicol Sci 178(2):391-403. doi:10.1093/toxsci/kfaa151 PMID:33078833 PMCID:PMC7751158
  • Chen Z, Liu Y, Wright FA, Chiu WA, Rusyn I. 2020. Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. ALTEX 37:623-638. doi:10.14573/altex.2002291 PMID:32521033
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2020. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicol Appl Pharmacol 400:115069. doi:10.1016/j.taap.2020.115069 PMID:32445755 PMCID:PMC7339121
  • Danforth C, Chiu WA, Rusyn I, Schultz K, Bolden A, Kwiatkowski C, Craft ES. 2020. An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction. Environ Int 134:14. doi:10.1016/j.envint.2019.105280 PMID:31704566
  • de Conti A, Tryndyak VP, Willett RA, Borowa-Mazgaj B, Watson A, Patton R, Khare S, Muskhelishvili L, Olsen GR, Avigan MI, Cerniglia CE, Ross SA, Sanyal AJ, Beland FA, Rusyn I, Pogribny IP. 2020. Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse collaborative cross mouse model. FASEB J 34:7773-7785. doi:10.1096/fj.202000194R PMID:32304142 PMCID:PMC755243
  • Grimm FA, Klaren WD, Li X, Lehmler H, Karmakar M, Robertson LW, Chiu WA, Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Perspect 128:77008. doi:10.1289/EHP7030 PMID:32701041 PMCID:PMC7377239
  • Luo Y, Aly NA, McCord JP, Strynar M, Chiu WA, Dodds J, Baker ES, Rusyn I. 2020. Rapid characterization of emerging per- and polyfluoroalkyl substances in aqueous film-forming foams using ion mobility spectrometry-mass spectrometry. Environ Sci Technol 54(23):15024-15034. doi:10.1021/acs.est.0c04798 PMID:33176098 PMCID:PMC7719402
  • Luo Y, Ferguson K, Rusyn I, Chiu WA. 2020. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicol Sci doi:10.1093/toxsci/kfaa007 PMID:32040194
  • Marvel S, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2020. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. (non-peer reviewed)
  • Marx U, Akabane T, Andersson TB, Baker E, Beilmann M, Beken S, Brendler-Schwaab S, Cirit M, David R, Dehne E, Durieux I, Ewart L, Fitzpatrick S, Frey O, Fuchs F, Griffith LG, Hamilton GA, Hartung T, Hoeng J, Hogberg HT, Hughes DJ, Ingber DE, Iskandar A, Kanamori T, Kojima H, Kuehnl J, Leist M, Li B, Loskill P, Mendrick D, Neumann T, Pallocca G, Rusyn I, Smirnova L, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tsyb S, Trapecar M, Van de Water B, Van den Eijnden-van Raaij J, Vulto P, Watanabe K, Wolf A, Zhou X, Roth A. 2020. Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX 37:365-394. doi:10.14573/altex.2001241 PMID:32113184 PMCID:PMC7863570
  • Rusyn I, Chiu WA, Wright FA. 2020. Questioning existing cancer hazard evaluation standards in the name of statistics. Toxicol Sci 177:521-522. doi:10.1093/toxsci/kfaa077 PMID:32462183
  • Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. 2020. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro 63:doi:10.1016/j.tiv.2019.104752 PMID:31857146


  • Alves VM, Borba J, Capuzzi SJ, Muratov EN, Andrade CH, Rusyn I, Tropsha A. 2019. Oy vey! A comment on machine learning of toxicological big data enables read-across structure activity relationships outperforming animal test reproducibility. Toxicol Sci 167:3-4. doi:10.1093/toxsci/kfy286 PMID:30500930 PMCID:PMC6317419
  • Bera G, Camargo K, Sericano JL, Liu Y, Sweet S, Horney JA, Jun M, Chiu WA, Rusyn I, Wade TL, Knap A. 2019. Baseline data for distribution of contaminants by natural disasters: Results from a residential Houston neighborhood during Hurricane Harvey flooding. Heliyon 5:e02860. doi:10.1016/j.heliyon.2019.e02860 PMID:31763489 PMCID:PMC6861583
  • Blanchette A, Grimm FA, Dalaijamts C, Hsieh N, Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Thorough QT/QTc in a dish: An In Vitro human model that accurately predicts clinical concentration-QTc relationships. Clin Pharmacol Ther 105:1175-1186. doi:10.1002/cpt.1259 PMID:30346629 PMCID:PMC6465173
  • Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711 PMID:31425687 PMCID:PMC6745256
  • Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicol In Vitro 60:245-251. doi:10.1016/j.tiv.2019.06.006 PMID:31195086 PMCID:PMC6717004
  • Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. 2019. Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers. Regul Toxicol Pharmacol 101:91-102. doi:10.1016/j.yrtph.2018.11.011 PMID:30471335 PMCID:PMC6333527
  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol 32(5):doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Luo Y, Cichocki JA, Hsieh N, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. 2019. Using Collaborative Cross mouse population to fill data gaps in risk assessment: A case study of population-based analysis of toxicokinetics and kidney toxicodynamics of tetrachloroethylene. Environ Health Perspect 127(6):67011. doi:10.1289/EHP5105 PMID:31246107 PMCID:PMC6792382
  • Onel M, Beykal B, Ferguson K, Chiu WA, McDonald TJ, Zhou L, House JS, Wright FA, Sheen D, Rusyn I, Pistikopoulos EN. 2019. Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLoS One 14(10):e0223517. doi:10.1371/journal.pone.0223517 PMID:31600275 PMCID:PMC6786635
  • Perry A, Lynch RM, Rusyn I, Threadgill DW. 2019. Long-term combinatorial exposure to trichloroethylene and inorganic arsenic in genetically heterogeneous mice results in renal tubular damage and cancer-associated molecular changes. G3 (Bethesda) 9(5):1729-1737. doi:10.1534/g3.119.400161 PMID:30898898 PMCID:PMC6505147


  • Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. 2018. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 35(1):51-64. doi:10.14573/altex.1703231 PMID:28738424 PMCID:PMC5783793
  • Chiu WA, Rusyn I. 2018. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. Mamm Genome 29(1-2):182-189. doi:10.1007/s00335-017-9731-6 PMID:29299621 PMCID:PMC5849521
  • Cichocki JA, Luo Y, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2018. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol Sci 167(1):126-137. doi:10.1093/toxsci/kfy223 PMID:30202895 PMCID:PMC6317418
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2018. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152. doi:10.1016/j.taap.2018.05.033 PMID:29857080 PMCID:PMC6051410
  • Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh N, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. 2018. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 35:441-452. doi:10.14573/altex.1805301 PMID:29999168 PMCID:PMC6231908
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39(4):614-622. doi:10.1093/carcin/bgy031 PMID:29562322 PMCID:PMC5888955
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Re: Application of the key characteristics of carcinogens in cancer hazard evaluation : response to Goodman, Lynch and Rhomberg. Carcinogenesis 39(8):1091-1093. doi:10.1093/carcin/bgy082 PMID:29982359 PMCID:PMC6067125
  • Klaren WD, Rusyn I. 2018. High-content assay multiplexing for muscle toxicity screening in human-induced pluripotent stem cell-derived skeletal myoblasts. Assay Drug Dev Technol 16(6):333-342. doi:10.1089/adt.2018.860 PMID:30070899 PMCID:PMC6114077
  • Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB. 2018. An empirical Bayes approach for multiple tissue eQTL analysis. Biostatistics 19(3):391-406. doi:10.1093/biostatistics/kxx048 PMID:29029013 PMCID:PMC6366007
  • Low Y, Alves VM, Fourches D, Sedykh A, Andrade CH, Muratov EN, Rusyn I, Tropsha A. 2018. Chemistry-wide association studies (CWAS): a novel framework for identifying and interpreting structure-activity relationships. J Chem Inf Model 58(11):2203-2213. doi:10.1021/acs.jcim.8b00450 PMID:30376324
  • Luo Y, Furuya S, Chiu WA, Rusyn I. 2018. Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A 81:37-52. doi:10.1080/15287394.2017.1408512 PMID:29190187
  • Luo Y, Furuya S, Soldatov VY, Kosyk O, Yoo HS, Fukushima H, Lewis L, Iwata Y, Rusyn I. 2018. Metabolism and toxicity of trichloroethylene and tetrachloroethylene in cytochrome P450 2E1 knockout and humanized transgenic mice. Toxicol Sci doi:10.1093/toxsci/kfy099 PMID:29897530
  • Luo Y, Hsieh N, Soldatow VY, Chiu WA, Rusyn I. 2018. Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43. doi:10.1016/j.tox.2018.07.012 PMID:30053492 PMCID:PMC6186498
  • Marvel S, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. 2018. ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics 19(1):80. doi:10.1186/s12859-018-2089-2 PMID:29506467 PMCID:PMC5838926
  • Onel M, Beykal B, Wang M, Grimm FA, Zhou L, Wright FA, Phillips TD, Rusyn I, Pistikopoulos EN. 2018. Optimal chemical grouping and sorbent material design by data analysis, modeling and dimensionality reduction techniques. Computer Aided Chemical Engineering 43:421-426. doi:10.1016/B978-0-444-64235-6.50076-0 PMID:30534632
  • Rusyn I, Greene N. 2018. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicol Sci 161:276-284. doi:10.1093/toxsci/kfx196 PMID:29378069
  • Rusyn I, Kleeberger SR, McAllister KA, French JE, Svenson KL. 2018. Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes. Mamm Genome 29(1-2):1-4. doi:10.1007/s00335-018-9740-0 PMID:29460122 PMCID:PMC5849569
  • Shapiro AJ, Antoni S, Guyton KZ, Lunn RM, Loomis D, Rusyn I, Jahnke GD, Schwingl PJ, Mehta SS, Addington J, Guha N. 2018. Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification. Environ Health Perspect 126:104501. doi:10.1289/EHP4224 PMID:30392397 PMCID:PMC6371692
  • Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I. 2018. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mamm Genome 29:168-181. doi:10.1007/s00335-018-9734-y PMID:29353386 PMCID:PMC6094947
  • Wignall JA, Muratov EN, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA. 2018. Conditional toxicity value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. Environ Health Perspect 126(5):057008. doi:10.1289/EHP2998 PMID:29847084 PMCID:PMC6071978


  • Cichocki JA, Furuya S, Konganti K, Luo Y, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2017. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice. J Pharmacol Exp Ther 361(1):17-28. doi:10.1124/jpet.116.238790 PMID:28148637 PMCID:PMC5363767
  • Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344
  • Grimm FA, Russell WK, Luo Y, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. 2017. Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. Environ Sci Technol 51:7197-7207. doi:10.1021/acs.est.6b06413 PMID:28502166 PMCID:PMC5627358
  • House JS, Grimm FA, Jima DD, Zhou Y, Rusyn I, Wright FA. 2017. A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics. Front Genet 8:168. doi:10.3389/fgene.2017.00168 PMID:29163636 PMCID:PMC5672545
  • Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I. 2017. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay Drug Dev Technol 15(6):267-279. doi:10.1089/adt.2017.786 PMID:28771372 PMCID:PMC5576216
  • Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. 2017. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol 322:60-74. doi:10.1016/j.taap.2017.02.020 PMID:28259702 PMCID:PMC5734940
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
  • Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274


  • Chappell G, Silva GO, Uehara T, Pogribny IP, Rusyn I. 2016. Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease. Cancer Med 5(3):574-585. doi:10.1002/cam4.606 PMID:26778414 PMCID:PMC4799957
  • Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. 2016. Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps. J Pharmacol Exp Ther 359(1):110-123. doi:10.1124/jpet.116.232629 PMID:27511820 PMCID:PMC5034707
  • Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton K, DeVito MJ, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper SC, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. 2016. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect 124(11):1671-1682. doi:10.1289/ehp233 PMID:27091369 PMCID:PMC5089888
  • Grimm FA, Iwata Y, Sirenko O, Chappell G, Wright FA, Reif DM, Braisted JA, Gerhold D, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde A, Rusyn I. 2016. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chem 18(16):4407-4419. doi:10.1039/c6gc01147k PMID:28035192 PMCID:PMC5179981
  • Marrone AK, Shpyleva S, Chappell G, Tryndyak VP, Uehara T, Beland FA, Rusyn I, Pogribny IP. 2016. Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice. Mol Carcinog 55(5):808-817. doi:10.1002/mc.22323 PMID:25865624
  • Portier CJ, Armstrong BK, Baguley B, Baur X, Belyaev I, Belle R, Belpoggi F, Biggeri A, Bosland MC, Bruzzi P, Budnik L, Bugge M, Burns K, Calaf GM, Carpenter DO, Carpenter H, Lopez-Carillo L, Clapp R, Cocco P, Consonni D, Comba P, Craft ES, Dalvie M, Davis D, Demers PA, De Roos AJ, DeWitt JC, Forastiere F, Freedman JH, Fritschi L, Gaus C, Gohlke J, Goldberg M, Greiser E, Hansen J, Hardell L, Hauptmann M, Huang W, Huff J, James MO, Jameson C, Kortenkamp A, Kopp-Schneider A, Kromhout H, Larramendy M, Landrigan PJ, Lash LH, Leszczynski D, Lynch CF, Magnani C, Mandrioli D, Martin FL, Merler E, Michelozzi P, Miligi L, Miller A, Mirabelli D, Mirer F, Naidoo S, Perry MJ, Petronio M, Pirastu R, Portier R, Ramos KS, Robertson LW, Rodriguez T, Roosli M, Ross M, Roy D, Rusyn I, Saldiva P, Sass J, Savolainen K, Scheepers P, Sergi C, Silbergeld EK, Smith MT, Stewart BW, Sutton P, Tateo F, Terracini B, Thielmann H, Thomas DB, Vainio H, Vena J, Vineis P, Weiderpass E, Weisenburger DD, Woodruff TJ, Yorifuji T, Yu I, Zambon P, Zeeb H, Zhou SF. 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health 70(8):741-745. doi:10.1136/jech-2015-207005 PMID:26941213 PMCID:PMC4975799
  • Rusyn I, Knap A. 2016. Environmental exposures due to natural disasters. Rev Environ Health 31(1):89-92. doi:10.1515/reveh-2016-0010 PMID:26982607 PMCID:PMC4913349
  • Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan R, Cogliano VJ, Straif K. 2016. Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environ Health Perspect 124(6):713-721. doi:10.1289/ehp.1509912 PMID:26600562 PMCID:PMC4892922


  • Abdo N, Wetmore BA, Chappell G, Shea D, Wright FA, Rusyn I. 2015. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environ Int 85:147-155. doi:10.1016/j.envint.2015.09.012 PMID:26386728 PMCID:PMC4773193
  • Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou Y, Jack J, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif A, Austin CP, Tice RR, Rusyn I, Wright FA. 2015. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect 123(5):458-466. doi:10.1289/ehp.1408775 PMID:25622337 PMCID:PMC4421772
  • Eduati F, Mangravite LM, Wang T, Tang H, Bare J, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y. 2015. Prediction of human population responses to toxic compounds by a collaborative competition. Nat Biotechnol 33(9):933-940. PMID:26258538
  • Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I. 2015. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Assay Drug Dev Technol 13(9):529-546. doi:10.1089/adt.2015.659 PMID:26539751 PMCID:PMC4652224
  • Pearce N, Blair AE, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli A, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, Mannetje A, McMichael AJ, McLaughlin J, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer F, Monson RR, Nordby K, Olshan A, Parent M, Perera F, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini A, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L, Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart P, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger DD, Wesseling C, Weiderpass E, Zahm SH. 2015. IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect 123(6):507-514. doi:10.1289/ehp.1409149 PMID:25712798 PMCID:PMC4455595
  • Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J Toxicol Environ Health A 78(1):15-31. doi:10.1080/15287394.2015.958417 PMID:25424544 PMCID:PMC4281929
  • Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A 78(1):32-49. doi:10.1080/15287394.2015.958418 PMID:25424545 PMCID:PMC4281933
  • Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar WM, Sweet S, Knap A, Wade TL, Campbell J, Clewell H, Melnyk SB, Chiu WA, Rusyn I. 2015. The contribution of peroxisome proliferator-activated receptor alpha to the relationship between toxicokinetics and toxicodynamics of trichloroethylene. Toxicol Sci 147(2):339-349. doi:10.1093/toxsci/kfv134 PMID:26136231 PMCID:PMC4598794



  • Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I. 2013. A systematic approach for identifying, evaluating, and presenting mechanistic evidence in human health assessments. Regul Toxicol Pharmacol 67(2):266-277. doi:10.1016/j.yrtph.2013.08.005 PMID:23959061 PMCID:PMC3818152
  • Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B, Moser M, Karasik E, Gillard B, Ramsey K, Sullivan S, Bridge J, Magazine H, Syron J, Fleming J, Siminoff L, Traino H, Mosavel M, Barker L, Jewell S, Rohrer D, Maxim D, Filkins D, Harbach P, Cortadillo E, Berghuis B, Turner L, Hudson E, Feenstra K, Sobin L, Robb J, Branton P, Korzeniewski G, Shive C, Tabor D, Qi L, Groch K, Nampally S, Buia S, Zimmerman A, Smith A, Burges R, Robinson K, Valentino K, Bradbury D, Cosentino M, Diaz-Mayoral N, Kennedy M, Engel T, Williams P, Erickson K, Ardlie K, Winckler W, Getz G, DeLuca D, MacArthur D, Kellis M, Thomson A, Young T, Gelfand E, Donovan M, Meng Y, Grant G, Mash D, Marcus Y, Basile M, Liu J, Zhu J, Tu Z, Cox NJ, Nicolae DL, Gamazon ER, Im HK, Konkashbaev A, Pritchard J, Stevens M, Flutre T, Wen X, Dermitzakis ET, Lappalainen T, Guigo R, Monlong J, Sammeth M, Koller D, Battle A, Mostafavi S, McCarthy M, Rivas M, Maller J, Rusyn I, Nobel AB, Wright FA, Shabalin AA, Feolo M, Sharopova N, Sturcke A, Paschal J, Anderson JM, Wilder EL, Derr LK, Green ED, Struewing JP, Temple G, Volpi S, Boyer JT, Thomson EJ, Guyer MS, Ng C, Abdallah A, Colantuoni D, Insel TR, Koester SE, Little A, Bender PK, Lehner T, Yao Y, Compton CC, Vaught JB, Sawyer S, Lockhart NC, Demchok J, Moore HF. 2013. The Genotype-Tissue Expression (GTEx) project. Nat Genet 45:580-585. doi:10.1038/ng.2653 PMID:23715323 PMCID:PMC4010069
  • Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. 2013. Integrative chemical-biological read-across approach for chemical hazard classification. Chem Res Toxicol 26(8):1199-1208. doi:10.1021/tx400110f PMID:23848138 PMCID:PMC3818153
  • Pogribny IP, Rusyn I. 2013. Environmental toxicants, epigenetics, and cancer. Advances in Experimental Medicine and Biology 754:215-232. doi:10.1007/978-1-4419-9967-2_11 PMID:22956504 PMCID:PMC4281087
  • Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I. 2013. ToxPi GUI: An interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics 29(3):402-403. doi:10.1093/bioinformatics/bts686 PMID:23202747 PMCID:PMC3988461
  • Rusyn I, Lemon SM. 2013. Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?. Cancer Lett doi:10.1016/j.canlet.2013.06.028 PMID:23871966 PMCID:PMC3844040
  • Soldatow VY, LeCluyse EL, Griffith LG, Rusyn I. 2013. In vitro models for liver toxicity testing. Toxicol Res (Camb) 2:23-39. doi:10.1039/C2TX20051A PMID:23495363 PMCID:PMC3593300
  • Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymoniak S, Bradford BU, Boorman GA, Bataller R, Rusyn I. 2013. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol Sci 132(1):53-63. doi:10.1093/toxsci/kfs342 PMID:23288052 PMCID:PMC3576012
  • Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. 2013. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol 266(2):224-232. doi:10.1016/j.taap.2012.11.019 PMID:23200774 PMCID:PMC3534780
  • Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ. 2013. Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect 121:23-31. doi:10.1289/ehp.1205687 PMID:23086705 PMCID:PMC3553440


  • Jeannot E, Boorman GA, Bradford BU, Shymoniak S, Tumurbaatar B, Weinman SA, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I, Kosyk O. 2012. Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice. Int J Cancer 130(6):1347-1356. doi:10.1002/ijc.26140 PMID:21500192 PMCID:PMC3161148
  • Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou Y, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. 2012. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci 126(2):578-588. doi:10.1093/toxsci/kfs023 PMID:22268004 PMCID:PMC3307611
  • Wright FA, Shabalin AA, Rusyn I. 2012. Computational tools for discovery and interpretation of expression quantitative trait loci. Pharmacogenomics 13(3):343-352. doi:10.2217/pgs.11.185 PMID:22304583 PMCID:PMC3295835


  • Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone MC, Threadgill DW, Tryndyak VP, Pogribny IP, Bleyle L, Koop DR, Rusyn I. 2011. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci 120(1):206-217. doi:10.1093/toxsci/kfq362 PMID:21135412 PMCID:PMC3044200
  • Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I. 2011. MicroRNA expression in the livers of inbred mice. Mutat Res 714:126-133. doi:10.1016/j.mrfmmm.2011.05.007 PMID:21616085 PMCID:PMC3166582
  • Jeannot E, Pogribny IP, Beland FA, Rusyn I. 2011. Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. Cancer Lett 301:161-167. doi:10.1016/j.canlet.2010.11.010 PMID:21168264 PMCID:PMC3035933
  • Koturbash I, Scherhag A, Sexton K, Bodnar WM, Tryndyak VP, Swenberg JA, Beland FA, Pogribny IP, Rusyn I, Latendresse JR. 2011. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-Butadiene. Environ Health Perspect 119:635-640. doi:10.1289/ehp.1002910 PMID:21147608 PMCID:PMC3094413
  • Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A. 2011. Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. Environ Health Perspect 119(3):364-370. doi:10.1289/ehp.1002476 PMID:20980217 PMCID:PMC3060000



  • DeSimone MC, Harbourt D, Boysen G, Collins LB, Waldyanatha S, Bradford BU, Threadgill DW, Rusyn I, Kim S. 2009. Analysis of trichloroethylene metabolism in a genetically diverse panel of mouse inbred strains. In: Society of Toxicology Annual Meeting. Baltimore, MD.
  • Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I. 2009. Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mamm Genome 20(7):437-446. doi:10.1007/s00335-009-9199-0 PMID:19609828 PMCID:PMC2745627
  • Gatti DM, Shabalin AA, Lam T, Wright FA, Rusyn I, Nobel AB. 2009. FastMap: fast eQTL mapping in homozygous populations. Bioinformatics 25(4):482-489. doi:10.1093/bioinformatics/btn648 PMID:19091771 PMCID:PMC2642639
  • Gatti DM, Sypa M, Rusyn I, Wright FA, Barry WT. 2009. SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy. Bioinformatics 25(4):541-542. doi:10.1093/bioinformatics/btn655 PMID:19098030 PMCID:PMC2642635
  • Hege A, Ross PK, Threadgill DW, Rusyn I. 2009. Phenotypic anchoring of gene expression data from acetaminophen hepatotoxicity studies in the mouse model of the human population reveals biomarkers of response. In: Society of Toxicology Annual Meeting. Baltimore, MD.
  • Kim S, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I, Collins LB. 2009. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology 262(3):230-238. doi:10.1016/j.tox.2009.06.013 PMID:19549554 PMCID:PMC2765814
  • Kim S, Kim D, Pollack GM, Collins LB, Rusyn I. 2009. Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicol Appl Pharmacol 238(1):90-99. doi:10.1016/j.taap.2009.04.019 PMID:19409406 PMCID:PMC2737827
  • Martinez S, Bradford BU, Kosyk O, Kaiser R, Soldatow VY, Stewart T, Amaral K, Black C, Ferguson S, LeCluyse EL, Rusyn I. 2009. Development of the in vitro toxicogenetic model for hepatotoxicity. In: Society of Toxicology Annual Meeting. Baltimore, MD.
  • Romanov S, Gatti DM, Tsuchlya M, Zeng M, Medvedev A, Rusyn I. 2009. Profiling of multiple transcription factors activity in mouse liver. In: Society of Toxicology Annual Meeting. Baltimore, MD.
  • Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, Cunningham ML, Rusyn I. 2009. Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. Toxicol Appl Pharmacol 235(2):199-207. doi:10.1016/j.taap.2008.12.011 PMID:19136022 PMCID:PMC2654411
  • Zhao N, Gatti DM, Rusyn I. 2009. Genome-level analysis of genetic regulation of sex-specific gene expression In mouse liver. In: Society of Toxicology Annual Meeting. Baltimore, MD.
  • Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A. 2009. A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environ Health Perspect 117(8):1257-64. PMID:19672406


  • Gatti DM, Shabalin AA, Rusyn I, Wright FA, Nobel AB. 2008. Fast association mapping using summation trees. In: 7th Annual Meeting of the Complex Traits Consortium,. Montreal, Canada.
  • Han J, Danell RM, Patel JR, Gumerov DR, Scarlett CO, Speir J, Parker C, Rusyn I, Zeisel S, Borchers CH. 2008. Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics 4(2):128-140. doi:10.1007/s11306-008-0104-8 PMID:19081807 PMCID:PMC2600444
  • Kim S, Collins LB, Pollack GM, Rusyn I. 2008. Pharmacokinetic modeling of trichloroethylene metabolism in B6C3F1 mice: Formation and disposition of trichloroacetic add, dichloroacetic add, S-(1,2-dichlorovinyl)glutathlone and S-(1,2-dichlorovlnyl)-L-cystelne. In: NIEHS Superfund Basic Research & Training Program 2008 Annual Meeting. Pacific Grove, CA.
  • Pogribny IP, Rusyn I, Beland FA. 2008. Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents. Environ Mol Mutagen 49(1):9-15. doi:10.1002/em.20342 PMID:17879298 PMCID:PMC2705440
  • Pogribny IP, Tryndyak VP, Boureiko A, Melnyk SB, Bagnyukova TV, Montgomery B, Rusyn I. 2008. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutat Res 644(1-2):17-23. doi:10.1016/j.mrfmmm.2008.06.009 PMID:18639561 PMCID:PMC2571982
  • Rusyn I, Harrill AH. 2008. Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opin Drug Metab Toxicol 4(11):1379-1389. doi:10.1517/17425255.4.11.1379 PMID:18950280
  • Zhu H, Rusyn I, Richard A, Tropsha A. 2008. Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environ Health Perspect 116(4):506-13. PMID:18414635


  • Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736
  • Woods CG, Burns AM, Maki A, Bradford BU, Cunningham ML, Connor HD, Kadiiska MB, Mason RP, Peters JM, Rusyn I. 2007. Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase. Free Radic Biol Med 42(3):335-342. PMID:17210446


  • DeSimone MC, Harbourt D, Boysen G, Collins LB, Bradford BU, Han J, Swenberg JA, Threadgill DW, Rusyn I. 2006. Multi-strain study of trichoroethylene toxicity in mice. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.
  • Han J, Harbourt D, Danell RM, Borchers CH, Rusyn I. 2006. High throughput metabolite profiling of serum from trichloroethylene-exposed mice by direct infusion FTICR-MS. In: Superfund Basic Research Program Annual Meeting, December 11-12. La Jolla, CA.


  • Bammler TK, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, Freedman JH, Fry RC, Harper A, Humble MC, Hurban P, Kavanagh TJ, Kaufmann WK, Kerr KF, Jing L, Lapidus JA, Lasarev MR, Li J, Li Y, Lobenhofer EK, Lu X, Malek RL, Milton S, Nagalla SR, O'Malley JP, Palmer VS, Pattee P, Paules RS, Perou CM, Phillips K, Qin L, Qiu Y, Quigley SD, Rodland M, Rusyn I, Samson LD, Schwartz DA, Shi Y, Shin J, Sieber SO, Slifer S, Speer MC, Spencer PS, Sproles DI, Swenberg JA, Suk WA, Sullivan RC, Tian R, Tennant RW, Todd SA, Tucker CJ, Van Houten B, Weis BK, Xuan S, Zarbl HF. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2(5):351-6. PMID:15846362


  • Rusyn I, Asakura S, Pachkowski BF, Bradford BU, Denissenko MF, Peters JM, Holland SM, Reddy JK, Cunningham ML, Swenberg JA. 2004. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: Identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Res 64(3):1050-1057. PMID:14871837


  • Rusyn I, Denissenko MF, Wong VA, Butterworth BE, Cunningham ML, Upton PB, Thurman RG, Swenberg JA. 2000. Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency. Carcinogenesis 21(12):2141-2145. PMID:11133801
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