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Your Environment. Your Health.

Person Details: John F. Gierthy

Superfund Research Program

John F. Gierthy

Wadsworth Center, New York State Department of Health
Empire State Plaza
Wadsworth Center
Albany, New York 12201
Phone: 518-474-8195


Research Briefs



  • Arcaro KF, Yang Y, Vakharia D, Gierthy JF. 2000. Toxaphene is antiestrogenic in a human breast-cancer cell assay. J Toxicol Environ Health A 59:197-210. PMID:10667634
  • Spink DC, Spink BC, Zhuo X, Hussain MM, Gierthy JF, Ding X. 2000. NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol 74(1-2):11-18. doi:10.1016/s0960-0760(00)00083-2 PMID:11074351
  • Vakharia D, Gierthy JF. 2000. Use of a combined human liver microsome-estrogen receptor assay to assess potential estrogen modulating activity of PCB metabolites. Toxicol Lett 114(1-3):55-65. PMID:10713469


  • Arcaro KF, O'Keefe PW, Yang Y, Clayton W, Gierthy JF. 1999. Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells. Toxicology 133(2-3):115-127. doi:10.1016/S0300-483X(99)00018-9 PMID:10378478
  • Arcaro KF, Yi L, Seegal R, Vakharia D, Yang Y, Spink DC, Brosch KO, Gierthy JF. 1999. 2,2',6,6'-tetrachlorobiphenyl is estrogenic in vitro and in vivo. J Cell Biochem 72(1):94-102. PMID:10025670
  • Vakharia D, Gierthy JF. 1999. Rapid assay for estrogen receptor binding to PCB metabolites. Toxicol In Vitro 13(2):275-282. PMID:20654485
  • Vakharia D, Gierthy JF. 1999. Rapid screen for ER-binding of human liver microsome-generated PCB-metabolites. Environ Health Perspect 42(1-S):221.


  • Arcaro KF, O'Keefe PW, Yang Y, Gierthy JF. 1998. Antiestrogenic activity of polycyclic aromatic hydrocarbons. Environ Health Perspect 42(1-S):240.
  • Arcaro KF, Vakharia D, Yang Y, Gierthy JF. 1998. Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides. Environ Health Perspect 106:1041-1046. PMID:9703490
  • Seegal R, Gierthy JF, Arcaro KF, Brosch KO. 1998. Neurochemical and neuroendocrine effects of non-coplanar and coplanar PCBs. Fundam Appl Toxicol 41:49-61.
  • Spink BC, Fasco MJ, Gierthy JF, Spink DC. 1998. 12-O-Tetradecanolyl-phorbol-13-acetate differentially alters CYP1A1 and CYP1B1 expression in MCF-7 breast cancer cells. J Cell Biochem 70(3):289-296.


  • Arcaro KF, Gierthy JF. 1997. Estrogenic responses of human breast cancer cells to combinations of hydroxylated PCBs, pesticides and 17 beta-estradiol. Environ Health Perspect 36(1):295.
  • Gierthy JF, Arcaro KF, Floyd M. 1997. Assessment of PCB estrogenicity in a human breast cancer cell line. Chemosphere 34(5-7):1495-1505. PMID:9134682
  • Gierthy JF, Yang Y, Robertson LW, Oakley GG, Arcaro KF, Vakharia D. 1997. Position of hydroxyl group influences PCB estrogenicity and antiestrogenicity. Environ Health Perspect 36(1):159.
  • Spink DC, Cao JQ, Gierthy JF, Hayes CL, Li Y, Sutter TR. 1997. Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN renal adenocarcinoma cells. Psychiatr Pol 62:223-232. PMID:9393958


  • Gierthy JF, Seegal R, Floyd M, Arcaro KF, Spink DC. 1996. Estrogenic activity of 2,2',6,6'-tetrachlorobiphenyl in MCF-7 human breast cancer cells. Environ Health Perspect 30:225-226.
  • Gierthy JF, Spink BC, Figge HL, Pentecost BT, Spink DC. 1996. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. J Cell Biochem 60:173-184. PMID:8655628
  • Seegal R, Chishti MA, Gierthy JF. 1996. Uterotropic and neurochemical effects of 2,2',6,6'-tetrachlorobiphenyl in the prepubertal rat. Environ Health Perspect 30:227.
  • Spink DC, Spink BC, Hayes CL, Cao JQ, Gierthy JF, Sutter TR. 1996. TCDD induces catechol estrogen metabolism and CYP1B1 in ACHN human renal adenocarcinoma cells. Environ Health Perspect 30:180.


  • Gierthy JF, Arcaro KF, Floyd M. 1995. Assessment and implications of PCB estrogenicity. In: Proceedings of the 15th International Symposium on Chlorinated Dioxins and Related Compounds. pp.419-423.
  • Seegal R, Gierthy JF. 1995. Developmental exposure to individual PCB congeners - multiple mechanisms of action. Neurotoxicology 16:753.
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