Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

University of Albany - SUNY

Superfund Research Program

PCB Estrogenicity in Human Breast Cells

Project Leader: John F. Gierthy (Wadsworth Center, New York State Department of Health)
Grant Number: P42ES004913
Funding Period: 1995 - 2000

Project-Specific Links

Project Summary (1995-2000)

The objective of this project is to evaluate the estrogenic potential of polychlorinated biphenyls (PCBs) and their metabolites in human derived systems by establishment of the metabolic mechanisms involved. The working hypothesis under consideration proposes that some PCBs are estrogenic and that this estrogenicity is dependent on the specific structure of the PCB and on its P450-catalyzed metabolism to a hydroxylated metabolite. The specific aims of the project are to evaluate the in vitro estrogenicity and antiestrogenicity of PCB congeners and metabolites in a human breast cancer cell line, to investigate the metabolism in human systems of selected PCB congeners, and to characterize the PCB metabolism potentiated in microsomes prepared from PCB exposed rat tissue.

Back
to Top