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Your Environment. Your Health.

Project Publications: University of Albany - SUNY: PCB Estrogenicity in Human Breast Cells

Superfund Research Program

PCB Estrogenicity in Human Breast Cells

Project Leader: John F. Gierthy (Wadsworth Center, New York State Department of Health)
Grant Number: P42ES004913
Funding Period: 1995 - 2000

Project-Specific Links



  • Arcaro KF, Yang Y, Vakharia D, Gierthy JF. 2000. Toxaphene is antiestrogenic in a human breast-cancer cell assay. J Toxicol Environ Health A 59:197-210. PMID:10667634
  • Vakharia D, Gierthy JF. 2000. Use of a combined human liver microsome-estrogen receptor assay to assess potential estrogen modulating activity of PCB metabolites. Toxicol Lett 114(1-3):55-65. PMID:10713469


  • Arcaro KF, O'Keefe PW, Yang Y, Clayton W, Gierthy JF. 1999. Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells. Toxicology 133(2-3):115-127. doi:10.1016/S0300-483X(99)00018-9 PMID:10378478
  • Vakharia D, Gierthy JF. 1999. Rapid assay for estrogen receptor binding to PCB metabolites. Toxicol In Vitro 13(2):275-282. PMID:20654485
  • Vakharia D, Gierthy JF. 1999. Rapid screen for ER-binding of human liver microsome-generated PCB-metabolites. Environ Health Perspect 42(1-S):221.


  • Arcaro KF, O'Keefe PW, Yang Y, Gierthy JF. 1998. Antiestrogenic activity of polycyclic aromatic hydrocarbons. Environ Health Perspect 42(1-S):240.
  • Arcaro KF, Vakharia D, Yang Y, Gierthy JF. 1998. Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides. Environ Health Perspect 106:1041-1046. PMID:9703490
  • Spink BC, Fasco MJ, Gierthy JF, Spink DC. 1998. 12-O-Tetradecanolyl-phorbol-13-acetate differentially alters CYP1A1 and CYP1B1 expression in MCF-7 breast cancer cells. J Cell Biochem 70(3):289-296.
  • Spink DC, Spink BC, Cao JQ, DePasquale JA, Pentecost BT, Fasco MJ, Li Y, Sutter TR. 1998. Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis 19(2):291-298. PMID:9498279


  • Arcaro KF, Gierthy JF. 1997. Estrogenic responses of human breast cancer cells to combinations of hydroxylated PCBs, pesticides and 17 beta-estradiol. Environ Health Perspect 36(1):295.
  • Gierthy JF, Arcaro KF, Floyd M. 1997. Assessment of PCB estrogenicity in a human breast cancer cell line. Chemosphere 34(5-7):1495-1505. PMID:9134682
  • Gierthy JF, Yang Y, Robertson LW, Oakley GG, Arcaro KF, Vakharia D. 1997. Position of hydroxyl group influences PCB estrogenicity and antiestrogenicity. Environ Health Perspect 36(1):159.
  • Spink DC, Cao JQ, Gierthy JF, Hayes CL, Li Y, Sutter TR. 1997. Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN renal adenocarcinoma cells. Psychiatr Pol 62:223-232. PMID:9393958
  • Spink DC, Spink BC, Cao JQ, DePasquale JA, Pentecost BT, Yi L, Sutter TR. 1997. Differential induction of CYP1A1 and CYP1B1 by TCDD in human breast cells and breast epithelial cells. Environ Health Perspect 36:24.


  • Gierthy JF, Seegal R, Floyd M, Arcaro KF, Spink DC. 1996. Estrogenic activity of 2,2',6,6'-tetrachlorobiphenyl in MCF-7 human breast cancer cells. Environ Health Perspect 30:225-226.
  • Gierthy JF, Spink BC, Figge HL, Pentecost BT, Spink DC. 1996. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells. J Cell Biochem 60:173-184. PMID:8655628


  • Gierthy JF, Arcaro KF, Floyd M. 1995. Assessment and implications of PCB estrogenicity. In: Proceedings of the 15th International Symposium on Chlorinated Dioxins and Related Compounds. pp.419-423.
  • Seegal R, Gierthy JF. 1995. Developmental exposure to individual PCB congeners - multiple mechanisms of action. Neurotoxicology 16:753.
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