Person Details: Rance Nault

Superfund Research Program

Rance Nault

Michigan State University

Research Briefs

• 337 - Dioxin Disrupts Liver Cells in Mice, Potential Link with Liver Disease

Publications

2023

• Cholico G, Orlowska K, Fling RR, Sink WJ, Zacharewski N, Fader KA, Nault R, Zacharewski TR. 2023. Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver. Sci Rep 13(1):4138. doi:10.1038/s41598-023-31087-9 PMID:36914879 PMCID:PMC1001158

2022

• Cholico G, Nault R, Zacharewski TR. 2022. Genome-wide ChIPseq analysis of AhR, COUP-TF, and HNF4 enrichment in TCDD-treated mouse liver. Int J Mol Sci 23(3):1558. doi:10.3390/ijms23031558 PMID:35163483 PMCID:PMC8836158
• Nault R, Saha S, Bhattacharya S, Dodson J, Sinha S, Maiti T, Zacharewski TR. 2022. Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs. Nucleic Acids Res doi:10.1093/nar/gkac019 PMID:35061903
• Nault R, Saha S, Bhattacharya S, Sinha S, Maiti T, Zacharewski TR. 2022. Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice. Toxicol Sci doi:10.1093/toxsci/kfac109 PMID:36222588
• Orlowska K, Fling RR, Nault R, Sink WJ, Schilmiller AL, Zacharewski TR. 2022. Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the beta-oxidation-like pathway resulting in acrylyl-CoA conjugate buildup. J Biol Chem 298(9):102301. doi:10.1016/j.jbc.2022.102301 PMID:35931118 PMCID:PMC9418907

2021

• Cholico G, Fling RR, Zacharewski TR, Zacharewski N, Fader KA, Nault R. 2021. Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic beta-oxidation. Sci Rep 11:15689. doi:10.1038/s41598-021-95214-0 PMID:34344994 PMCID:PMC8333094
• Nault R, Fader KA, Zacharewski TR. 2021. Single-nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cell Mol Gastroenterol Hepatol 11:147-159. doi:10.1016/j.jcmgh.2020.07.012 PMID:32791302 PMCID:PMC7674514

2020

• Doskey CM, Fader KA, Nault R, Lydic TA, Matthews J, Potter D, Sharratt B, Williams K, Zacharewski TR. 2020. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicol Appl Pharmacol 398:14. doi:10.1016/j.taap.2020.115034 PMID:32387183 PMCID:PMC7294678
• Fling RR, Doskey CM, Fader KA, Nault R, Zacharewski TR. 2020. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice. Sci Rep 10:14831. doi:10.1038/s41598-020-71795-0 PMID:32908189 PMCID:PMC7481292

2019

• Fader KA, Nault R, Doskey CM, Fling RR, Zacharewski TR. 2019. 2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice. Sci Rep 9:6514. doi:10.1038/s41598-019-42760-3 PMID:31015483 PMCID:PMC6478849

2018

• Fader KA, Nault R, Raehtz S, McCabe LR, Zacharewski TR. 2018. 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol 348:85-98. doi:10.1016/j.taap.2018.04.013 PMID:29673856 PMCID:PMC5984050
• Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski TR. 2018. Comparison of hepatic NRF2 and aryl hydrocarbon receptor binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated mice demonstrates NRF2-independent PKM2 induction. Mol Pharmacol 94(2):876-884. doi:10.1124/mol.118.112144 PMID:29752288 PMCID:6022803

2017

• Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. 2017. Convergence of hepcidin defiency, systemic iron overloading, heme accumulation, and REV-ERBalpha/beta activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol 321:1-17. doi:10.1016/j.taap.2017.02.006 PMID:28213091
• Fader KA, Nault R, Kumagai K, Harkema JR, Zacharewski TR, Zhang C. 2017. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism. Sci Rep 7:5921. doi:10.1038/s41598-017-05656-8 PMID:28725001 PMCID:PMC5517430
• Kovalova N, Nault R, Crawford RB, Zacharewski TR, Kaminski NE. 2017. Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells. Toxicol Appl Pharmacol 316:95-106. doi:10.1016/j.taap.2016.11.009 PMID:27913140 PMCID:PMC5292778
• Nault R, Fader KA, Lydic TA, Zacharewski TR. 2017. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Res Toxicol 30(4):1060-1075. doi:10.1021/acs.chemrestox.6b00430 PMID:28238261
• Nault R, Fader KA, Zacharewski TR. 2017. Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice. PLoS One 12:17. doi:10.1371/journal.pone.0184842 PMID:28922406 PMCID:PMC5602546

2016

• Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski TR. 2016. Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis. Toxicol Sci 154(2):253-266. doi:10.1093/toxsci/kfw163 PMID:27562557 PMCID:PMC5139066
• Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. 2016. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 149(2):358-371. doi:10.1093/toxsci/kfv245 PMID:26582802 PMCID:PMC4900217
• Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk J. 2016. From the cover: coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis. Toxicol Sci 154(2):381-391. doi:10.1093/toxsci/kfw175 PMID:27613713 PMCID:PMC5139072

2015

• Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. 2015. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism and depletes immune cell populations in the jejunum of C57BL/6 mice. Toxicol Sci 148(2):567-580. doi:10.1093/toxsci/kfv206 PMID:26377647 PMCID:PMC5009443
• Nault R, Colbry D, Brandenberger C, Zacharewski TR, Harkema JR. 2015. Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features. Toxicol Pathol 43(3):366-375. doi:10.1177/0192623314544379 PMID:25274660 PMCID:PMC4382446
• Nault R, Fader KA, Zacharewski TR. 2015. RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice. BMC Genomics 16:373. doi:10.1186/s12864-015-1527-z PMID:25958198 PMCID:PMC4456707

2013

• Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR. 2013. Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci 135(2):465-475. doi:10.1093/toxsci/kft156 PMID:23864506 PMCID:PMC3807621
• Nault R, Forgacs AL, Dere E, Zacharewski TR. 2013. Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver. Toxicol Lett 223(1):52-59. doi:10.1016/j.toxlet.2013.08.013 PMID:23994337 PMCID:PMC4096832
• Nault R, Kim S, Zacharewski TR. 2013. Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice. Toxicol Appl Pharmacol 267(2):184-191. doi:10.1016/j.taap.2012.11.028 PMID:23238561 PMCID:PMC4104405