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Person Details

Superfund Research Program

Mark E. Hahn

Woods Hole Oceanographic Institution
Biology Department, MS-32
Woods Hole, MA 02543-1049
Phone: 508-289-3242
Fax: 508-457-2134
Email: mhahn@whoi.edu

Projects

Research Briefs

Hazardous Waste Sites

Atlantic Wood Industries

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

Atlantic Wood Site, Elizabeth River

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

Black Rock Harbor, Bridgeport, CT

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

New Bedford Harbor

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

Newark Yacht Club

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

Publications

2017

  • Hahn ME, Karchner SI, Merson RR. 2017. Diversity as Opportunity: Insights from 600 Million Years of AHR Evolution. Curr Opin Toxicol 2:58-71. doi:10.1016/j.cotox.2017.02.003 PMID:28286876 PMCID:PMC5343764
  • Parente T, Moreira DA, Magalhaes M, de Andrade PC, Furtado C, Haas B, Stegeman JJ, Hahn ME. 2017. The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families. Mar Pollut Bull 115(1-2):352-361. doi:10.1016/j.marpolbul.2016.12.012 PMID:28062095 PMCID:PMC5310677
  • Reid N, Jackson CE, Gilbert D, Minx P, Montague MJ, Hampton TH, Helfrich LW, King BL, Nacci DE, Aluru N, Karchner SI, Colbourne JK, Hahn ME, Shaw JR, Oleksiak MF, Crawford DL, Warren WC, Whitehead A. 2017. The landscape of extreme genomic variation in the highly adaptable Atlantic killifish. Genome Biol Evol doi:10.1093/gbe/evx023 PMID:28201664
  • Whitehead A, Clark BW, Reid N, Hahn ME, Nacci DE. 2017. When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations. Evol Appl doi:10.1111/eva.12470

2016

  • Nacci DE, Hahn ME, Karchner SI, Jayaraman S, Mostello C, Miller KM, Blackwell CG, Nisbet IC. 2016. Integrating Monitoring and Genetic Methods To Infer Historical Risks of PCBs and DDE to Common and Roseate Terns Nesting Near the New Bedford Harbor Superfund Site (Massachusetts, USA). Environ Sci Technol 50(18):10226-10235. doi:10.1021/acs.est.6b02108 PMID:27564328 PMCID:PMC5110212
  • Parente T, Moreira DA, Magalhaes M, Andrade PC, Furtado C, Haas B, Stegeman JJ, Hahn ME. 2016. The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families. Mar Pollut Bull 115:352-361.
  • Reid N, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci DE, Oleksiak MF, Crawford DL, Whitehead A. 2016. The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. Science 354(6317):1305-1308. doi:10.1126/science.aah4993 PMID:27940876 PMCID:PMC5206662
  • Townley IK, Karchner SI, Skripnikova E, Wiese T, Hahn ME, Rees BB. 2016. Sequence and functional characterization of hypoxia inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish, Fundulus heteroclitus. Am J Physiol Regul Integr Comp Physiol doi:10.1152/ajpregu.00402.2016
  • Wincent E, Kubota A, Timme-Laragy A, Jonsson ME, Hahn ME, Stegeman JJ. 2016. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol 110-111:117-129. doi:10.1016/j.bcp.2016.04.012 PMID:27112072 PMCID:PMC4887394

2015

2014

  • Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney EA. 2014. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS One 9(11):e113158. doi:10.1371/journal.pone.0113158 PMID:25402455 PMCID:PMC4234671
  • Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger JJ, Sherr DH, Silverstone AE, Hahn ME, McCune JM. 2014. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9(2):15. doi:10.1371/journal.pone.0087877 PMID:24498387 PMCID:PMC3912126
  • Parks A, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. 2014. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86(5):593-608. doi:10.1124/mol.114.093369 PMID:25159092 PMCID:PMC4201140
  • Reitzel AM, Karchner SI, Franks DG, Evans BR, Nacci DE, Champlin D, Vieira VM, Hahn ME. 2014. Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol 14:6. doi:10.1186/1471-2148-14-6 PMID:24422594 PMCID:PMC3899389

2013

  • Bainy AC, Kubota A, Goldstone JV, Lille-Langoy R, Karchner SI, Celander MC, Hahn ME, Goksoyr A, Stegeman JJ. 2013. Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquat Toxicol 142-143:447-457. doi:10.1016/j.aquatox.2013.09.014 PMID:24121122 PMCID:PMC3873750
  • Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison MS. 2013. Comparative analysis of homology models of the AH receptor ligand binding domain: Verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52:714-725. doi:10.1021/bi301457f PMID:23286227 PMCID:PMC3568667
  • Harbeitner RC, Hahn ME, Timme-Laragy AR. 2013. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology 22:387-401. doi:10.1007/s10646-012-1033-x PMID:23329125 PMCID:PMC3573531
  • Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radic Biol Med 65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011 PMID:23770340 PMCID:PMC3823629
  • Williams LM, Timme-Laragy AR, Goldstone JV, McArthur AG, Stegeman JJ, Smolowitz RM, Hahn ME. 2013. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One doi:10.1371/journal.pone.0079574 PMID:24298298 PMCID:PMC3840143

2011

2010

2009

  • Hahn ME, Allan LL, Sherr DH. 2009. Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor. Biochem Pharmacol 77(4):485-497. doi:10.1016/j.bcp.2008.09.016 PMID:18848529 PMCID:PMC2701375
  • Karchner SI, Jenny MJ, Tarrant AM, Evans BR, Kang HJ, Bae I, Sherr DH, Hahn ME. 2009. The active form of human aryl hydrocarbon receptor (AHR) repressor lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible factor. Mol Cell Biol 29(13):3465-3477. doi:10.1128/MCB.00206-09 PMID:19380484 PMCID:PMC2698758

2008

  • Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME. 2008. Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: Role of DNA binding and competition for AHR nuclear translocator. Mol Pharmacol 73(2):387-98. PMID:18000031
  • Hansson MC, Hahn ME. 2008. Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms. Aquat Toxicol 86(2):121-30. PMID:18063141
  • Matson CW, Clark BW, Jenny MJ, Fleming CR, Hahn ME, Di Giulio RT. 2008. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquat Toxicol 87(4):289-295. doi:10.1016/j.aquatox.2008.02.010 PMID:18378331 PMCID:PMC2413436
  • Whalen KE, Morin D, Lin C, Tjeerdema RS, Goldstone JV, Hahn ME. 2008. Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum. Arch Biochem Biophys 478(1):7-17. doi:10.1016/j.abb.2008.07.007 PMID:18671936

2007

  • Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618
  • Carvan MJ, Gallagher EP, Goksoyr A, Hahn ME, Joakim DG. 2007. Fish models in toxicology. Zebrafish 4(1):9-20. doi:10.1089/zeb.2006.9998 PMID:18041939
  • Hahn ME, Hestermann EV. 2007. Receptor-mediated mechanisms of toxicity. Chapter 5 in: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL. pp.235-272.
  • Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 100(1):180-93. PMID:17686920
  • Reddy CM, Stegeman JJ, Hahn ME. 2007. Organic Pollutants: Presence and Effects in Humans and Marine Animals. Chapter 7 in: Oceans and Human Health: Risks and Remedies from the Seas. pp.121-144.

2006

  • Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. 2006. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol 300(1):366-384. doi:10.1016/j.ydbio.2006.08.066 PMID:17097629 PMCID:PMC3166225
  • Hahn ME, Karchner SI, Evans BR, Franks DG, Merson RR, Lapseritis JM. 2006. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomic. J Exp Zool 305(9):693-706. PMID:16902966
  • Merson RR, Franks DG, Karchner SI, Hahn ME. 2006. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. Comp Biochem Physiol C Toxicol Pharmacol 142(1-2):85-94. doi:10.1016/j.cbpc.2005.10.013 PMID:16364694
  • Tarrant AM, Greytak SR, Callard GV, Hahn ME. 2006. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. J Mol Endocrinol 37(1):105-20. PMID:16901928

2005

  • Evans BR, Karchner SI, Franks DG, Hahn ME. 2005. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo. Arch Biochem Biophys 441(2):151-167. doi:10.1016/j.abb.2005.07.008 PMID:16122694
  • Yang X, Liu D, Murray TJ, Mitchell GC, Hesterman EV, Karchner SI, Merson RR, Hahn ME, Sherr DH. 2005. The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene 24(53):7869-7881. doi:10.1038/sj.onc.1208938 PMID:16091746

2004

  • Hahn ME, Karchner SI, Franks DG, Merson RR. 2004. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenet Genomics 14(2):131-143. PMID:15077014
  • Powell WH, Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ, Hahn ME. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Mar Environ Res 58(2-5):119-124. PMID:15178023

2003

  • Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environ Toxicol Chem 22(10):2337-2343. PMID:14551997

2002

  • Bard SM, Bello SM, Hahn ME, Stegeman JJ. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquat Toxicol 59(3-4):237-251. PMID:12127740
  • Karchner SI, Franks DG, Powell WH, Hahn ME. 2002. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. J Biol Chem 277(9):6949-6959. doi:10.1074/jbc.M110779200 PMID:11742002
  • Powell WH, Hahn ME. 2002. Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants. J Exp Zool 294(1):17-29. PMID:11932946

2001

  • Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicol Sci 60(1):77-91. PMID:11222875
  • Hahn ME. 2001. Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models. Mar Biotechnol (NY) 3:S224-S238. PMID:14961319
  • Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol 53(2):127-138. PMID:11311389

2000

  • Betka M, Welenc A, Franks DG, Hahn ME, Callard GV. 2000. Characterization of two aryl hydrocarbon receptor (AHR) mRNA forms in Squalus acanthias and stage-dependent expression during spermatogenesis. The Bulletin: Mount Desert Island Biological Laboratory 39:65-67.
  • Karchner SI, Kennedy SW, Trudeau S, Hahn ME. 2000. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Mar Environ Res 50(1-5):51-56. PMID:11460741
  • Powell WH, Bright R, Bello SM, Hahn ME. 2000. Developmental and Tissue-specific Expression of AHR1, AHR2, and ARNT2 in Dioxin-sensitive and -resistant Populations of the Marine Fish, Fundulus heteroclitus. Toxicol Sci 57(2):229-239. PMID:11006353
  • Powell WH, Hahn ME. 2000. The evolution of aryl hydrocarbon signaling proteins: Diversity of ARNT isoforms among fish species. Mar Environ Res 50(1-5):39-44. PMID:11460724
  • Quadri SA, Qadri AN, Hahn ME, Mann KK, Sherr DH. 2000. The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor (AhR) Activation and Polycyclic Aromatic Hydrocarbon-induced Pre-B cell Apoptosis. Mol Pharmacol 58:515-525. PMID:10953044
  • Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2000. TCDD induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol

1999

  • Betka M, Welenc A, Hahn ME, Callard GV. 1999. Stage-related distribution of two arylhydrocarbon receptor (AhR) mRNA variants and differential effects of Ah ligands on cell proliferation and death during spermatogenesis in the spiny dogfish shark (Squalus acanthias). In: Proceedings of the 1999 SETAC (Society of Environmental Toxcology and Chemistry) Annual Meeting.
  • Black VH, Shaw PM, Karchner SI, Powell WH, Hahn ME. 1999. Differential expression of CYP1A1 and CYP1A2, but not AHR or ARNT, in guinea pig adrenal and liver. Endocr Res 24:631-632.
  • Karchner SI, Powell WH, Hahn ME. 1999. Structural and Functional Characterization of Two Highly Divergent Aryl Hydrocarbon Receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel class of ligand-binding basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) factors. J Biol Chem 274:33814-33824.
  • Mann KK, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The Role of DMBA Metabolites in PreB Cell Apoptosis. Toxicol Sci 48(1-S):
  • Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The Role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced Pre-B Cell Apoptosis. Toxicol Appl Pharmacol 161:10-22.
  • Powell WH, Karchner SI, Bright R, Hahn ME. 1999. Functional diversity of vertebrate ARNT proteins: identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus. Arch Biochem Biophys 361(1):156-163. doi:10.1006/abbi.1998.0992 PMID:9882441

1998

  • Bello SM, Franks DG, Stegeman JJ, Hahn ME. 1998. Dioxin Resistance in Killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund Site: In Vivo and In Vitro studies of CYP1A1 Inducibility. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC. pp.168.
  • Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. 1998. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol Sci 43(2):161-171. doi:10.1006/toxs.1998.2455 PMID:9710958
  • Hahn ME. 1998. Mechanisms of innate and acquired resistance to dioxin-like compounds. Reviews in Toxicology: Series B - Environmental Toxicology 2:395-443.
  • Hahn ME. 1998. The Aryl Hydrocarbon Receptor: A Comparative Perspective. Comp Biochem Physiol 121(1-3):23-53. PMID:9972449
  • Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1998. The aryl hydrocarbon receptor in early vertebrates. Mar Environ Res 46(1-5):41-44.
  • Powell WH, Karchner SI, Hahn ME. 1998. Aryl Hydrocarbon Signaling Components in Fundulus heteroclitus: A Phylogenetic Perspective. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC.

1997

  • Bello SM, Stegeman JJ, Hahn ME. 1997. Lack of cytochrome P450-1A inducibility in Fundulus heteroclitus from New Bedford Harbor: A case of dioxin resistance?. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • Hahn ME, Karchner SI, Perera SA, Shapiro MA. 1997. Evolution of the Ah Receptor: Evidence for two AhR genes in early vertebrates. Environ Health Perspect 36:242.
  • Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1997. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci U S A 94(25):13743-13748. PMID:9391097 PMCID:PMC28377
  • Karchner SI, Hahn ME. 1997. Molecular Characterization of Two Aryl Hydrocarbon (Ah) Receptors in the Mummichog Fundulus heteroclitus. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA. pp.426.

1996

  • Hahn ME, Karchner SI, Perera SA. 1996. Molecular studies on the Ah receptor (AhR) in early vertebrates (bony and cartilaginous fish) and evidence for a second vertebrate AhR gene. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.232.

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