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Your Environment. Your Health.

Person Details

Superfund Research Program

Mark E. Hahn

Woods Hole Oceanographic Institution
Biology Department, MS-32
Woods Hole, MA 02543-1049
Phone: 508-289-3242
Fax: 508-457-2134


Research Briefs

Hazardous Waste Sites

Atlantic Wood Industries

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

Atlantic Wood Site, Elizabeth River

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

New Bedford Harbor

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish



  • Wincent E, Kubota A, Timme-Laragy A, Jonsson ME, Hahn ME, Stegeman JJ. 2016. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacoldoi:10.1016/j.bcp.2016.04.012



  • Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney EA. 2014. The transcriptional response to oxidative stress in vertebrate embryos: Effects of tert butylhydroquinone and 2,3,7,8- tetrachlorodibenzo-p-dioxin. PLoS One9(11):e113158. doi:10.1371/journal.pone.0113158 PMID:25402455 PMCID:PMC4234671
  • Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger JJ, Sherr DH, Silverstone AE, Hahn ME, McCune JM. 2014. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One9(2):15. doi:10.1371/journal.pone.0087877
  • Parks A, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. 2014. In silico identification of an aryl hydrocarbon receptor (AHR) antagonist with biological activity in vitro and in vivo. Mol Pharmacol86(5):593-608. doi:10.1124/mol.114.093369 PMID:25159092 PMCID:PMC4201140
  • Reitzel AM, Karchner SI, Franks DG, Evans BR, Nacci DE, Champlin D, Vieira VM, Hahn ME. 2014. Genetic diversity at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol 14:6. doi:10.1186/1471-2148-14-6 PMCID:PMC3899389


  • Bainy AC, Kubota A, Goldstone JV, Lille-Langoy R, Karchner SI, Celander MC, Hahn ME, Goksoyr A, Stegeman JJ. 2013. Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquatic Toxicology142-143:447-457. doi:10.1016/j.aquatox.2013.09.014
  • Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison MS. 2013. Comparative analysis of homology models of the AH receptor ligand binding domain: Verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry52:714-725. doi:10.1021/bi301457f
  • Harbeitner RC, Hahn ME, Timme-Laragy AR. 2013. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology 22:387-401. doi:10.1007/s10646-012-1033-x
  • Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radical Biology and Medicine65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011 PMID:23770340 PMCID:PMC3823629
  • Williams LM, Timme-Laragy AR, Goldstone JV, McArthur AG, Stegeman JJ, Smolowitz RM, Hahn ME. 2013. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS Onedoi:10.1371/journal.pone.0079574



  • Aluru N, Karchner SI, Hahn ME. 2010. Role of DNA methylation of AHR1 and AHR2 promoters in differential sensitivity to PCBs in Atlantic Killifish, Fundulus heteroclitus. Aquatic Toxicology101:288-94. doi:10.1016/j.aquatox.2010.10.010
  • Greytak SR, Tarrant AM, Nacci DE, Hahn ME, Callard GV. 2010. Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific. Aquatic Toxicology99(2):291-299. doi:10.1016/j.aquatox.2010.05.009
  • Howard G, Schlezinger JJ, Hahn ME, Webster TF. 2010. Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists. Environ Health Perspect 118:666-672. doi:10.1289/ehp.0901312



  • Evans BR, Karchner SI, Allan LL, Pollenz RS, Tanguay RL, Jenny MJ, Sherr DH, Hahn ME. 2008. Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: Role of DNA binding and competition for AHR nuclear translocator. Mol Pharmacol73(2):387-98.
  • Hansson MC, Hahn ME. 2008. Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms. Aquatic Toxicology86(2):121-30.
  • Matson CW, Clark BW, Jenny MJ, Fleming CR, Hahn ME, Di Giulio RT. 2008. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquatic Toxicology87(4):289-95. doi:10.1016/j.aquatox.2008.02.010


  • Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics2(4):257-286. doi:10.1016/j.cbd.2007.09.001
  • Carvan MJ, Gallagher EP, Goksoyr A, Hahn ME, Joakim DG. 2007. Fish models in toxicology. Zebrafish4:9-20.
  • Hahn ME, Hestermann EV. 2007. Receptor-mediated mechanisms of toxicity. Chapter 5 in: The Toxicology of Fishes. Taylor & Francis, Boca Raton, FL. pp.235-272.
  • Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences100(1):180-93.
  • Reddy CM, Stegeman JJ, Hahn ME. 2007. Organic Pollutants: Presence and Effects in Humans and Marine Animals. Chapter 7 in: Oceans and Human Health: Risks and Remedies from the Seas. pp.121-144.


  • Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. 2006. The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol300(1):366-84. doi:10.1016/j.ydbio.2006.08.066
  • Hahn ME, Karchner SI, Evans BR, Franks DG, Merson RR, Lapseritis JM. 2006. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomic. Journal of Experimental Zoology 305(9):693-706.
  • Merson RR, Franks DG, Karchner SI, Hahn ME. 2006. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology 142:85-94.
  • Tarrant AM, Greytak SR, Callard GV, Hahn ME. 2006. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. J Mol Endocrinol37(1):105-20.


  • Evans BR, Karchner SI, Franks DG, Hahn ME. 2005. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: Structure, function, evolution, and AHR-dependent regulation in vivo. Arch Biochem Biophys441(2):151-167.
  • Yang X, Liu D, Murray TJ, Mitchell GC, Hesterman EV, Karchner SI, Merson RR, Hahn ME, Sherr DH. 2005. The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene24(53):7869-7881.


  • Hahn ME, Karchner SI, Franks DG, Merson RR. 2004. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenet Genomics14(2):131-143.
  • Powell WH, Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ, Hahn ME. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Mar Environ Res58(2-5):119-124.


  • Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental Toxicology and Chemistry22(10):2337-2343.


  • Bard SM, Bello SM, Hahn ME, Stegeman JJ. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquatic Toxicology59(3-4):237-251.
  • Karchner SI, Franks DG, Powell WH, Hahn ME. 2002. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. Journal of Biological Chemistry277:6949-6959.
  • Powell WH, Hahn ME. 2002. Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants. Journal of Experimental Zoology 294(1):17-29.


  • Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine Superfund site: In vivo and in vitro studies on the inducibility of xenobiotic-metabolizing enzymes. Toxicological Sciences60(1):77-91.
  • Hahn ME. 2001. Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models. Marine Biotechnology3:S224-S238.
  • Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology53(2):127-138.


  • Betka M, Welenc A, Franks DG, Hahn ME, Callard GV. 2000. Characterization of two aryl hydrocarbon receptor (AHR) mRNA forms in Squalus acanthias and stage-dependent expression during spermatogenesis. The Bulletin: Mount Desert Island Biological Laboratory 39:65-67.
  • Karchner SI, Kennedy SW, Trudeau S, Hahn ME. 2000. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Mar Environ Res50(1-5):51-56.
  • Powell WH, Bright R, Bello SM, Hahn ME. 2000. Developmental and Tissue-specific Expression of AHR1, AHR2, and ARNT2 in Dioxin-sensitive and -resistant Populations of the Marine Fish, Fundulus heteroclitus. Toxicological Sciences57(2):229-239.
  • Powell WH, Hahn ME. 2000. The evolution of aryl hydrocarbon signaling proteins: Diversity of ARNT isoforms among fish species. Mar Environ Res50(1-5):39-44.
  • Quadri SA, Qadri AN, Hahn ME, Mann KK, Sherr DH. 2000. The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor (AhR) Activation and Polycyclic Aromatic Hydrocarbon-induced Pre-B cell Apoptosis. Mol Pharmacol58:515-525.
  • Toomey BH, Bello SM, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Giulio RT. 2000. TCDD induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology


  • Betka M, Welenc A, Hahn ME, Callard GV. 1999. Stage-related distribution of two arylhydrocarbon receptor (AhR) mRNA variants and differential effects of Ah ligands on cell proliferation and death during spermatogenesis in the spiny dogfish shark (Squalus acanthias). In: Proceedings of the 1999 SETAC (Society of Environmental Toxcology and Chemistry) Annual Meeting.
  • Black VH, Shaw PM, Karchner SI, Powell WH, Hahn ME. 1999. Differential expression of CYP1A1 and CYP1A2, but not AHR or ARNT, in guinea pig adrenal and liver. Endocr Res 24:631-632.
  • Karchner SI, Powell WH, Hahn ME. 1999. Structural and Functional Characterization of Two Highly Divergent Aryl Hydrocarbon Receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel class of ligand-binding basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) factors. Journal of Biological Chemistry274:33814-33824.
  • Mann KK, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The Role of DMBA Metabolites in PreB Cell Apoptosis. Toxicological Sciences48(1-S):
  • Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The Role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced Pre-B Cell Apoptosis. Toxicol Appl Pharmacol161:10-22.
  • Powell WH, Karchner SI, Bright R, Hahn ME. 1999. Functional diversity of vertebrate ARNT proteins: Identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus. Arch Biochem Biophys361(1):156-163.


  • Bello SM, Franks DG, Stegeman JJ, Hahn ME. 1998. Dioxin Resistance in Killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund Site: In Vivo and In Vitro studies of CYP1A1 Inducibility. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC. pp.168.
  • Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. 1998. Low inducibility of CYPIA activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYPIA inhibition. Toxicological Sciences43(2):161-171.
  • Hahn ME. 1998. Mechanisms of innate and acquired resistance to dioxin-like compounds. Reviews in Toxicology: Series B - Environmental Toxicology 2:395-443.
  • Hahn ME. 1998. The Aryl Hydrocarbon Receptor: A Comparative Perspective. Comp Biochem Physiol121(1-3):23-53.
  • Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1998. The aryl hydrocarbon receptor in early vertebrates. Mar Environ Res46(1-5):41-44.
  • Powell WH, Karchner SI, Hahn ME. 1998. Aryl Hydrocarbon Signaling Components in Fundulus heteroclitus: A Phylogenetic Perspective. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC.


  • Bello SM, Stegeman JJ, Hahn ME. 1997. Lack of cytochrome P450-1A inducibility in Fundulus heteroclitus from New Bedford Harbor: A case of dioxin resistance?. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • Hahn ME, Karchner SI, Perera SA, Shapiro MA. 1997. Evolution of the Ah Receptor: Evidence for two AhR genes in early vertebrates. The Toxicologist36:242.
  • Hahn ME, Karchner SI, Shapiro MA, Perera SA. 1997. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHRI and AHR2) and the PAS family. Proceedings of the National Academy of Sciences of the United States of America (USA)94(25):13743-13748.
  • Karchner SI, Hahn ME. 1997. Molecular Characterization of Two Aryl Hydrocarbon (Ah) Receptors in the Mummichog Fundulus heteroclitus. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA. pp.426.


  • Hahn ME, Karchner SI, Perera SA. 1996. Molecular studies on the Ah receptor (AhR) in early vertebrates (bony and cartilaginous fish) and evidence for a second vertebrate AhR gene. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.232.

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