Superfund Research Program

Aaron Barchowsky Ph.D.

University of Pittsburgh
Department of Environmental and Occupational Health
Bridgeside Point, 100 Technology Drive
Room 332, CLMCS
Pittsburgh, Pennsylvania 15219-3130
Phone: 412-624-8864
Email: abarchowsky@eoh.pitt.edu

Projects

• Dartmouth College: Induction of Oxidative Stress and Activation of Transcription Factors by Toxic Metals (1995 - 2000)
• Dartmouth College: Mechanism of Arsenic-Induced Vascular Disease (2000-2005)

Research Briefs

• 58 - Mechanisms Underlying Arsenic-Induced Vascular Disease

Publications

2021

• Lind L, Araujo JA, Barchowsky A, Belcher SM, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT. 2021. Key characteristics of cardiovascular toxicants. Environ Health Perspect 129(9):95001. doi:10.1289/EHP9321 PMID:34558968 PMCID:PMC8462506

2017

• Moon KA, Oberoi S, Barchowsky A, Chen Y, Guallar E, Nachman KE, Rahman M, Sohel N, D'Ippoliti D, Wade TJ, James KA, Farzan SF, Karagas MR, Ahsan H, Navas-Acien A. 2017. A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. Int J Epidemiol 46:1924-1939. doi:10.1093/ije/dyx202 PMID:29040626 PMCID:PMC5837344

2011

• States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC. 2011. Arsenic toxicology: translating between experimental models and human pathology. Environ Health Perspect 119:1356-1363. doi:10.1289/ehp.1103441 PMID:21684831 PMCID:PMC3230447

2007

• Straub AC, Stolz DB, Ross MA, Hernandez-Zavala A, Soucy NV, Klei LR, Barchowsky A. 2007. Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver. Hepatology 45(1):205-12. PMID:17187425
• Straub AC, Stolz DB, Vin H, Ross MA, Soucy NV, Klei LR, Barchowsky A. 2007. Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol Appl Pharmacol 222(3):327-36. PMID:17123562

2005

• Soucy NV, Mayka DD, Klei LR, Nemec AA, Bauer JA, Barchowsky A. 2005. Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice. Cardiovasc Toxicol 5(1):29-42. PMID:15738583

2004

• Soucy NV, Klei LR, Mayka DD, Barchowsky A. 2004. Signaling pathways for arsenic-stimulated vascular endothelial growth factor-a expression in primary vascular smooth muscle cells. Chem Res Toxicol 17(4):555-563. PMID:15089098

2003

• Andrew AS, Warren AJ, Barchowsky A, Temple KA, Klei L, Soucy NV, O'Hara KA, Hamilton JW. 2003. Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect 111(6):825-838. PMID:12760830
• Barchowsky A, O'Hara KA. 2003. Metal-induced cell signaling and gene activation in lung diseases. Free Radic Biol Med 34(9):1130-1135. PMID:12706493
• O'Hara KA, Klei LR, Barchowsky A. 2003. Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol 190(3):214-223. PMID:12902192
• Soucy NV, Ihnat MA, Kamat CD, Hess L, Post MJ, Klei L, Clark C, Barchowsky A. 2003. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci 76(2):271-279. doi:10.1093/toxsci/kfg231 PMID:12970581

2002

• Barchowsky A, Soucy NV, O'Hara KA, Hwa J, Noreault-Conti TL, Andrew AS. 2002. A novel pathway for nickel-induced interleukin-8 expression. J Biol Chem 277(27):24225-24231. PMID:11978798
• Soucy NV, Barchowsky A, Klei L, Hamilton JW, Ihnat MA. 2002. Potential cellular mechanisms for arsenite-induced vascular diseases. Toxicol Sci 66(S1):86.

2001

• Andrew AS, Klei LR, Barchowsky A. 2001. AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. Am J Physiol 281(3):L616-L623. PMID:11504688
• Andrew AS, Klei LR, Barchowsky A. 2001. Nickel requires hypoxia inducible factor-1a, not redox signaling to induce plasminogen activator inhibitor-1. Am J Physiol 281(3):L607-L615. PMID:11504687
• Andrew AS, Klei LR, Barchowsky A. 2001. Role of oxidative, AP-1, and hypoxia-responsive signaling pathways in induction of plasminogen activator inhibitor-1 (PAI-1) by nickel. Environ Health Perspect 60:212.
• Smith KR, Klei LR, Barchowsky A. 2001. Arsenite stimulates plasma membrane NADPH oxidase activity in vascular endothelial cells. Am J Physiol 280(3):L442-L449. PMID:11159027
• Soucy NV, Andrew AS, Barchowsky A. 2001. Nickel induces IL-8 expression in human airway epithelial cells. Environ Health Perspect 60:317.
• Soucy NV, Klei LR, Barchowsky A. 2001. Mechanisms for arsenite-stimulated vascular cell angiogenic and profibrotic gene expression. Free Radic Biol Med 31:S62.

2000

• Andrew AS, Barchowsky A. 2000. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. Toxicol Appl Pharmacol 168(1):50-57. PMID:11000099
• Andrew AS, Klei LR, Barchowsky A. 2000. Role of oxidative, AP-1, and hypoxia-responsive signaling pathways in induction of plasminogen activator inhibitor-1 (PAI-1) by nickel. Free Radic Biol Med 29:S53.
• Barchowsky A, Frleta D, Vincenti MP. 2000. Integration of the NF-kB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine 12(10):1469-1479. PMID:11023661
• Barchowsky A, Klei LR, Smith KR, Ross CR. 2000. Oxidant signaling mechanisms initiated by low levels of arsenic in vascular cells. In: Metal Ions in Biology and Medicine. Vol. 6. John Libbey Eurotext, Paris, France. pp.47-49.
• Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. 2000. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-jun N-terminal kinase, and nuclear factor B: Differential regulation of collagenase 1 and collagenase 3. Arthritis & Rheumatism 43(4):801-811. PMID:10765924
• Roussel RR, Barchowsky A. 2000. Arsenic inhibits NF-kB-mediated gene transcription by blocking IkB kinase activity and IkBa phosphorylation and degradation. Arch Biochem Biophys 377(1):204-212.

1999

• Barchowsky A, Klei LR, Dudek EJ, Swartz HM, James PE. 1999. Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite. Free Radic Biol Med 27(11-12):1405-1412. PMID:10641735
• Barchowsky A, Roussel RR, Klei LR, James PE, Ganju N, Smith KR, Dudek EJ. 1999. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways. Toxicol Appl Pharmacol 159(1):65-75. PMID:10448126
• Chen CY, Sillett KS, Folt CL, Whittemore S, Barchowsky A. 1999. Molecular and demographic measures of arsenic stress in D. pulex. Hydrobiologia 410:229-238.
• Shumilla JA, Barchowsky A. 1999. Inhibition of protein synthesis by chromium(VI) differentially affects expression of urokinase and its receptor in human type II pneumocytes. Toxicol Appl Pharmacol 158(3):288-295. PMID:10438662
• Shumilla JA, Broderick RJ, Wang Y, Barchowsky A. 1999. Chromium(VI) inhibits the transciptional activity of Nuclear Factor-kB by decreasing the interaction of p65 with cAMP-responsive element-binding protein-binding protein. J Biol Chem 274(51):36207-36212. PMID:10593907

1998

• Shumilla JA, Wetterhahn KE, Barchowsky A. 1998. Inhibition of NF-kB binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism. Arch Biochem Biophys 349(2):356-362. PMID:9448725

1997

• Barchowsky A, Lannon BM, Elmore LC, Treadwell MD. 1997. Increased focal adhesion kinase- and urokinase-type plasminogen activator receptor-associated cell signaling in endothelial cells exposed to asbestos. Toxicol Appl Pharmacol 105(Suppl.5):1131-1137. PMID:9400712

1996

• Barchowsky A, Dudek EJ, Treadwell MD, Wetterhahn KE. 1996. Arsenic induces oxidant stress and NF-ÇB activation in cultured aortic endothelial cells. Free Radic Biol Med 21(6):783-790. PMID:8902524