Superfund Research Program
Immunoassays for Human and Environmental Health Monitoring
Over last funding cycle, the Immunoassays for Human and Environmental Health Monitoring Project has been actively working on preparing the reagents for new cycle of llama immunization to produce nanobodies to five targets of interest identified by the following Projects: Optimizing Bioremediation for Risk Reduction Using Integrated Bioassay, Non-Target Analysis and Genomic Mining Techniques, Critical Role of Mitochondrial Oxidative Stress (MOS) in Chemical Induced Cardiac Toxicity, and Monitoring Endoplasmic Reticulum Stress Caused by Chronic Exposure to Chemicals. The immunization is ongoing, and the preliminary results look promising. Several new formats of immunoassay have been proposed and tested giving excellent results in sensitivity, and also providing rapid screening tools.