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Progress Reports: Boston University: Early Life Exposure to Tetrachloroethylene (PCE)-Contaminated Drinking Water and Social Stressors may Interact to Increase the Risk of Substance Use Later in Life

Superfund Research Program

Early Life Exposure to Tetrachloroethylene (PCE)-Contaminated Drinking Water and Social Stressors may Interact to Increase the Risk of Substance Use Later in Life

Project Leader: Ann Aschengrau
Co-Investigators: Lisa Gallagher, Richard Saitz, Renee Boynton-Jarrett
Grant Number: P42ES007381
Funding Period: 2000-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2019  2018  2017  2016  2015  2014  2013  2012  2010  2009  2008  2007  2006  2005  2004  2003  2002  2001  2000 

Ann Aschengrau, Sc.D., and her team completed data collection for their study on the combined impact of early life exposure to PCE-contaminated drinking water and social stressors on drug and alcohol use in the Cape Cod region of Massachusetts and are currently in the midst of data analysis. Given the epidemic of substance use disorders in this region and the US, it is crucial to follow-up the team’s prior finding that early life exposure to PCE-contaminated drinking water increases the risk of substance use with the current study. By taking into account the multifactorial etiology of substance use, this research will identify possible avenues for prevention and intervention for this societal problem. During this period, the project team also co-authored an invited paper summarizing their prior SRP research findings on the reproductive and developmental effects of prenatal PCE exposure, and prepared manuscripts using SRP data on: (1) residential proximity to roadways and the occurrence of stillbirths (Butler, 2019), and (2) the impact of family and community socioeconomic status on the risk of adolescent drug use. Findings described in these manuscripts suggest that living within 50 meters of a roadway modestly increases the risk of stillbirth related to placental dysfunction and that family socioeconomic status has a greater impact on the risk of adolescent drug use than community SES measures.

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