Superfund Research Program

Ann Aschengrau

Boston University
Department of Epidemiology
Boston University School of Public Health
715 Albany St.
Boston, Massachusetts 02115
Phone: 617-638-5228
Fax: 617-638-4458
Email: aaschen@bu.edu

Projects

• Boston University: Early Life Exposure to Tetrachloroethylene (PCE)-Contaminated Drinking Water and Social Stressors may Interact to Increase the Risk of Substance Use Later in Life (2000-2021)
• Boston University: Perchloroethylene (PCE) in Drinking Water and Cancer Risk (1995 - 2000)

Research Briefs

• 270 - Prenatal PCE Exposure and Maternal Alcohol Use Linked to Increased Risks of Teenage Drug Use
• 247 - PCE in Drinking Water Linked to Cancer and Epilepsy
• 212 - Early-life PCE Exposure Linked to Visual Impairment in Adults
• 189 - Use of Spatial and Temporal Analyses to Provide Insights into the Environmental Etiology of Cancer
• 125 - Epidemiologic Research on Environmental Pollution and the Risk of Disease

Publications

2023

• Aschengrau A, Winter MR, Shea M. 2023. Association between resilience promotion factors during childhood and risk of drug use disorder during adulthood. Addict Subst Abus 2(1):1-10. doi:10.46439/addiction.2.007 PMID:37427318 PMCID:PMC10326717

2020

• Aschengrau A, Grippo A, Winter MR, Shea M, White RF, Saitz R. 2020. Drug use disorder following early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study. Environmental Health 19:99. doi:10.1186/s12940-020-00638-2 PMID:32943075 PMCID:PMC7495895
• Aschengrau A, Winter MR, Gallagher L, Vieira VM, Butler L, Fabian MP, Carwile JL, Wesselink AK, Mahalingaiah S, Janulewicz PA, Weinberg JM, Webster TF, Ozonoff DM. 2020. Reproductive and developmental health effects of prenatal exposure to tetrachloroethylene-contaminated drinking water. Environ Sci Process Impacts 22:555-566. doi:10.1039/c9em00590k PMID:32051987

2019

• Butler L, Gallagher L, Winter MR, Fabian MP, Wesselink AK, Aschengrau A. 2019. Residential proximity to roadways and placental-associated stillbirth: a case-control study. Int J Environ Health Res 31:465-474. doi:10.1080/09603123.2019.1673882 PMID:31587563 PMCID:PMC7131873

2018

• Aschengrau A, Gallagher L, Winter MR, Butler L, Patricia FM, Vieira VM. 2018. Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths. Environ Health 17:58. doi:10.1186/s12940-018-0402-1 PMID:29970097 PMCID:PMC6029409
• Aschengrau A, Gallagher LG, Winter MR, Butler L, Fabian MP, Vieira VM. 2018. Modeled exposure to tetrachloroethylene-contaminated drinking water and the occurrence of birth defects: a case-control study from Massachusetts and Rhode Island. Environ Health 17(1):75. doi:10.1186/s12940-018-0419-5 PMID:30400949 PMCID:PMC6219161
• Wesselink AK, Hatch EE, Wise L, Rothman KJ, Vieira VM, Aschengrau A. 2018. Exposure to tetrachloroethylene-contaminated drinking water and time to pregnancy. Environ Res 167:136-143. doi:10.1016/j.envres.2018.07.012 PMID:30014895

2017

• Butler L, Janulewicz PA, Carwile JL, White RF, Winter MR, Aschengrau A. 2017. Childhood and adolescent fish consumption and adult neuropsychological performance: An analysis from the Cape Cod Health Study. Neurotoxicol Teratol 61:47-57. doi:10.1016/j.ntt.2017.03.001 PMID:28263856
• Gallagher LG, Webster TF, Aschengrau A. 2017. Exploring associations between prenatal solvent exposures and teenage drug and alcohol use: a retrospective cohort study. Environ Health 16(1):26. doi:10.1186/s12940-017-0232-6 PMID:28283038 PMCID:PMC5346200
• Wesselink AK, Carwile JL, Fabian MP, Winter MR, Butler L, Mahalingaiah S, Aschengrau A. 2017. Residential proximity to roadways and ischemic placental disease in the Cape Cod Family Health Study. Int J Environ Res Public Health 14:682. doi:10.3390/ijerph14070682 PMID:28672786 PMCID:PMC5551120

2016

• Aschengrau A, Gallagher LG, Winter MR, Vieira VM, Webster TF, Janulewicz PA, Ozonoff DM. 2016. No association between unintentional head injuries and early-life exposure to tetrachloroethylene (PCE)-contaminated drinking water. J Occup Environ Med 58(10):1040-1045. doi:10.1097/JOM.0000000000000850 PMID:27513173 PMCID:PMC5704661
• Aschengrau A, Janulewicz PA, White RF, Vieira VM, Gallagher LG, Getz KD, Webster TF, Ozonoff DM. 2016. Long-term neurotoxic effects of early-life exposure to tetrachloroethylene-contaminated drinking water. Ann Glob Health 82(1):169-179. doi:10.1016/j.aogh.2016.01.013 PMID:27325074 PMCID:PMC4916338
• Carwile JL, Butler L, Janulewicz PA, Winter MR, Aschengrau A. 2016. Childhood fish consumption and learning and behavioral disorders. Int J Environ Res Public Health 13(11):doi:10.3390/ijerph13111069 PMID:27827868 PMCID:PMC5129279
• Hewlett MM, Chow E, Aschengrau A, Mahalingaiah S. 2016. Prenatal exposure to endocrine disruptors: a developmental etiology for polycystic ovary syndrome. Reprod Sci 24(1):19-27. doi:10.1177/1933719116654992 PMID:27342273
• Mahalingaiah S, Hart JE, Laden F, Farland LV, Hewlett MM, Chavarro J, Aschengrau A, Missmer SA. 2016. Adult air pollution exposure and risk of infertility in the Nurses' Health Study II. Hum Reprod 31(3):638-647. doi:10.1093/humrep/dev330 PMID:26724803 PMCID:PMC4755443
• Mahalingaiah S, Winter MR, Aschengrau A. 2016. Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study. Reprod Toxicol 65:87-94. doi:10.1016/j.reprotox.2016.07.005 PMID:27412368 PMCID:PMC5091798

2015

• Aschengrau A, Winter MR, Vieira VM, Webster TF, Janulewicz PA, Gallagher LG, Weinberg JM, Ozonoff DM. 2015. Long-term health effects of early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study. Environ Health 14:36. doi:10.1186/s12940-015-0021-z PMID:25889838 PMCID:PMC4397674
• Hoffman K, Aschengrau A, Webster TF, Bartell SM, Vieira VM. 2015. Associations between residence at birth and mental health disorders: a spatial analysis of retrospective cohort data. BMC Public Health 15:688. doi:10.1186/s12889-015-2011-z PMID:26195105 PMCID:PMC4508761

2014

• Mahalingaiah S, Hart JE, Aschengrau A, Laden F, Missmer SA. 2014. Air pollution exposures during adulthood and risk of endometriosis in the Nurses' Health Study II. Environ Health Perspect 122(1):58-64. doi:10.1289/ehp.1306627 PMID:24225723 PMCID:PMC3888567
• Mahalingaiah S, Hart JE, Laden F, Aschengrau A, Missmer SA, Terry KL, Boynton-Jarrett R. 2014. Air pollution and risk of uterine leiomyomata. Epidemiology 25(5):682-688. doi:10.1097/EDE.0000000000000126 PMID:24815304 PMCID:PMC4209294
• Winter MR, Mahalingaiah S, Aschengrau A, Carwile JL. 2014. Prenatal drinking-water exposure to tetrachloroethylene and ischemic placental disease: a retrospective cohort study. Environ Health 13:72. doi:10.1186/1476-069X-13-72 PMID:25270247 PMCID:PMC4183765

2013

• Janulewicz PA, Killiany RJ, White RF, Martin BR, Winter MR, Weinberg JM, Aschengrau A. 2013. Structural Magnetic Resonance Imaging in an adult cohort following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol Teratol 38:13-20. doi:10.1016/j.ntt.2013.03.060 PMID:23571160 PMCID:PMC3893699

2012

• Getz KD, Janulewicz PA, Rowe S, Weinberg JM, Winter MR, Martin BR, Vieira VM, White RF, Aschengrau A. 2012. Prenatal and early childhood exposure to tetrachloroethylene and adult vision. Environ Health Perspect doi:10.1289/ehp.1103996 PMID:22784657 PMCID:PMC3440105
• Janulewicz PA, White RF, Martin BR, Winter MR, Weinberg JM, Vieira VM, Aschengrau A. 2012. Adult neuropsychological performance following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol Teratol 34(3):350–359. doi:10.1016/j.ntt.2012.04.001 PMID:22522125 PMCID:PMC3553661

2010

• Gallagher LG, Webster TF, Aschengrau A, Vieira VM. 2010. Using residential history and groundwater modeling to examine drinking water exposure and breast cancer. Environ Health Perspect 118(6):749-755. doi:10.1289/ehp.0901547 PMID:20164002 PMCID:PMC2898849
• Young RL, Weinberg JM, Vieira VM, Aschengrau A, Webster TF. 2010. A multilevel non-hierarchical study of birth weight and socioeconomic status. Int J Health Geogr 9:36. doi:10.1186/1476-072X-9-36 PMID:20618954 PMCID:PMC2909180

2008

• Aschengrau A, Gallagher LG, Webster TF, Heeren T, Ozonoff DM, Spence LA. 2008. Evaluation of the Webler-Brown model for estimating tetrachloroethylene exposure from vinyl-lined asbestos-cement pipes. Environ Health 7:24. doi:10.1186/1476-069X-7-24 PMID:18518975 PMCID:PMC2432054
• Aschengrau A, Weinberg JM, Rogers S, Gallagher LG, Winter MR, Vieira VM, Webster TF, Ozonoff DM. 2008. Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of adverse birth outcomes. Environ Health Perspect 116(6):814-820. doi:10.1289/ehp.10414 PMID:18560539 PMCID:PMC2430239
• Janulewicz PA, White RF, Winter MR, Weinberg JM, Gallagher LG, Vieira VM, Webster TF, Aschengrau A. 2008. Risk of learning and behavioral disorders following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicol Teratol 30(3):175-185. doi:10.1016/j.ntt.2008.01.007 PMID:18353612 PMCID:PMC2494864
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2008. Spatial-temporal analysis of breast cancer in upper Cape Cod, Massachusetts. Int J Health Geogr 7:46. doi:10.1186/1476-072X-7-46 PMID:18700963 PMCID:PMC2538515
• Webster TF, Hoffman K, Weinberg JM, Vieira VM, Aschengrau A. 2008. Community- and individual-level socioeconomic status and breast cancer risk: multilevel modeling on Cape Cod, Massachusetts. Environ Health Perspect 116(8):1125-1129. doi:10.1289/ehp.10818 PMID:18709175 PMCID:PMC2516595

2006

• Aschengrau A. 2006. Drinking water detective story: connecting water contamination and disease. 77(5):9. (non-peer reviewed)
• Bradbury BD, Wilk JB, Aschengrau A, Lash TL. 2006. Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer. J Carcinog 5:3. doi:10.1186/1477-3163-5-3 PMID:16417624 PMCID:PMC1373621
• Brody JG, Aschengrau A, Swartz CH, McKelvey W, Rudel RA. 2006. Breast cancer risk and drinking water contaminated by wastewater: a case control study. Environ Health 5:28. doi:10.1186/1476-069X-5-28 PMID:17026759 PMCID:PMC1622744
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2006. Temporal-Spatial analysis of breast cancer on upper Cape Cod, Massachusetts. In: Proceedings of the Spatial Epidemiology Conference, 2006. London, United Kingdom. pp.115-119.
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2006. Temporal-spatial analysis of breast cancer risk on upper Cape Cod, Massachusetts, USA. Epidemiology 19:S484.
• Webster TF, Vieira VM, Weinberg JM, Aschengrau A. 2006. Method for mapping population-based case-control studies: an application using generalized additive models. Int J Health Geogr 5:26. doi:10.1186/1476-072X-5-26 PMID:16764727 PMCID:PMC1526437
• Webster TF, Weinberg JM, Vieira VM, Hoffman K, Aschengrau A. 2006. The impact of community and individual-level socioeconomic status on the risk of breast cancer: multi-level modeling in Massachusetts. Epidemiology 17(6):S210.

2005

• Lash TL, Bradbury BD, Wilk JB, Aschengrau A. 2005. A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology. Breast Cancer Research 7(3):R385-R393. PMID:15987434
• Ozonoff A, Webster TF, Vieira VM, Weinberg JM, Ozonoff DM, Aschengrau A. 2005. Cluster detection methods applied to the Upper Cape Cod cancer data. Environ Health 4:19. doi:10.1186/1476-069X-4-19 PMID:16164750 PMCID:PMC1242352
• Vieira VM, Aschengrau A, Ozonoff DM. 2005. Impact of tetrachloroethylene-contaminated drinking water on the risk of breast cancer: using a dose model to assess exposure in a case-control study. Environ Health 4(1):3. doi:10.1186/1476-069X-4-3 PMID:15733317 PMCID:PMC554766
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A. 2005. Spatial analysis of low birth weight on Cape Cod, MA using generalized additive modeling. Epidemiology 16(5):S104.
• Vieira VM, Webster TF, Weinberg JM, Aschengrau A, Ozonoff DM. 2005. Spatial analysis of lung, colorectal, and breast cancer on Cape Cod: an application of generalized additive models to case-control data. Environ Health 4:11. doi:10.1186/1476-069X-4-11 PMID:15955253 PMCID:PMC1183231

2004

• Brody JG, Aschengrau A, McKelvey W, Rudel RA, Swartz CH, Kennedy T. 2004. Breast cancer risk and historical exposure to pesticides from wide-area applications assessed with GIS. Environ Health Perspect 112(8):889-897. PMID:15175178

2003

• Aschengrau A, Rogers S, Ozonoff DM. 2003. Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. Environ Health Perspect 111(2):167-173. PMID:12573900
• Webster TF, Vieira VM, Weinberg JM, Aschengrau A. 2003. Spatial Analysis of Lung, Breast and Colorectal Cancer Using Generalized Additive Models. In: Proceedings of the EUROHEIS-SAHSU (European Health and Environment Information System-Small Area Health Statistics Unit) Conference 2003. Small Area Health Statistics Unit. Imperial College, London, England.

2002

• Lash TL, Aschengrau A. 2002. A null association between active or passive cigarette smoking and breast cancer risk. Breast Cancer Res Treat 75(2):181-184. PMID:12243511
• Paulu C, Aschengrau A, Ozonoff DM. 2002. Exploring associations between residential location and breast cancer incidence in a case-control study. Environ Health Perspect 110(5):471-478. PMID:12003750
• Vieira VM, Webster TF, Aschengrau A, Ozonoff DM. 2002. A method for spatial analysis of risk in a population-based case-control study. Int J Hyg Environ Health 205(1-2):115-120. PMID:12018004

2001

• Morabia A, Lash TL, Aschengrau A. 2001. Passive cigarette smoking and breast cancer. In: Environmental tobacco smoke: toxicity, treatment and prevention. CRC Press, Boca Raton, FL.

2000

• Lash TL, Aschengrau A. 2000. Alcohol drinking and risk of breast cancer. Breast J 6(6):396-399. PMID:11348398

1999

• Paulu C, Aschengrau A, Ozonoff DM. 1999. Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers. Environ Health Perspect 107(4):265-271. PMID:10090704

1998

• Aschengrau A, Paulu C, Ozonoff DM. 1998. Tetrachloroethylene-contaminated drinking water and the risk of breast cancer. Environ Health Perspect 106:947-953. PMID:9703477