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Progress Reports: Columbia University: Integrated Science Support Core

Superfund Research Program

Integrated Science Support Core

Project Leader: Joseph H. Graziano
Co-Investigator: Richard Buchsbaum
Grant Number: P42ES010349
Funding Period: 2017-2021
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2019  2018  2017 

The Data Management Unit of the ISSC continues to collect data and distribute datasets to SRP investigators. In 2019, Trace Metal Core Laboratory of the ISSC conducted thousands of analyses in blood and urine samples from human study populations exposed to a variety of elements including arsenic, lead, manganese and selenium. The output of this laboratory supported 13 peer reviewed publications, by 12 different lead authors, in journals that included J. Immunotoxicol, Toxicol Appl Pharm, EHP, Environ Res, PloS One, PloS Genet, Am J Clin Nutr, and others. Four of the 13 papers published in 2019 dealt with the impact of arsenic exposure on immune function in children and adults. For example, Faruque Parvez, Dr.P.H. and his collaborators reported that early life exposure to low dose arsenic in drinking water alters innate immune function in children (Parvez et al, 2019), while arsenic exposure in adults was associated with changes in peripheral blood mononuclear cells populations and subsets of T-cells (Lauer et al, 2019).

Another body of work relates to the impact of arsenic exposure on the health of adolescents, an age group that is quite understudied. Yu Chen, Ph.D., and colleagues, for example, reported that early life exposure to arsenic was significantly associated with subtle elevations in blood pressure during adolescence. At the same time, a pilot study by Khalid Khan, Dr.P.H., an alumni of the program, along with other colleagues, reported that the impact of arsenic exposure on thyroid function may provide a mechanistic link whereby arsenic impairs neurobehavioral performance in adolescents (Khan et al, 2019).

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