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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Final Progress Reports: Louisiana State University: Pollutant-Particle Systems and Xenobiotic Bioactivation

Superfund Research Program

Pollutant-Particle Systems and Xenobiotic Bioactivation

Project Leader: Wayne L. Backes (LSU Health Sciences Center - New Orleans)
Co-Investigator: James R. Reed (LSU Health Sciences Center - New Orleans)
Grant Number: P42ES013648
Funding Period: 2011-2018
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Final Progress Reports

Year:   2017 

Wayne Backes, Ph.D., and his research team have performed experiments that support their previous work demonstrating differences in the mechanism of P450 inhibition by environmentally persistent free radicals (EPFRs). The research results point to EPFRs changing the interaction of the POR with CYP2B4, and consequently the functional complex between the proteins. In contrast, EPFRs simply appear to block the active site of CYP1A2, with its inhibition not affecting the conformation of the POR-CYP1A2 interaction, and therefore similarly inhibiting product formation and each of the side reactions. An understanding of these interactions is extremely important in that EPFRs can differentially influence (1) the disposition of drugs and foreign compounds, and (2) the relative amounts of reactive intermediates that are generated. These factors can have a profound effect on the ability of the P450 system to function and can be a determinate of EPFR toxicity.

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